How far is San Antonio, TX from Muleshoe, TX?
The driving distance from San Antonio, TX to Muleshoe, TX is about 453.4 miles (729.7 km), with a travel time of about 07h 56m by car.
- The straight-line flight distance is about 414.3 miles (666.8 km).
- For a round trip, plan for roughly 15h 52m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 07h 56m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Runnels County, Texas, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms then Slight Chance Showers And Thunderstorms
Sunny
Driving Route Map
The map below follows the saved road route between San Antonio and Muleshoe.
Turn-by-Turn Driving Directions
Step-by-step road directions between San Antonio and Muleshoe.
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1
Start on Dolorosa Street
44 m · 5 sec · Dolorosa Street
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2
Continue on West Market Street
1042 ft · 28 sec · West Market Street
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3
Turn left onto Navarro Street
1.3 km · 2 min · Navarro Street
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4
Enter the roundabout and take exit 2 toward San Pedro Avenue
26 m · 2 sec · San Pedro Avenue
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5
Exit the roundabout onto San Pedro Avenue
2891 ft · 1 min · San Pedro Avenue
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6
Turn left onto West Cypress Street
604 ft · 10 sec · West Cypress Street
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7
Turn straight onto East Fredericksburg Road
1.2 mi · 2 min · East Fredericksburg Road
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8
Turn right onto Interstate 10 West
657 ft · 13 sec · Interstate 10 West
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9
Take the ramp slight left toward I 10 West, US 87 North
553 ft · 14 sec
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10
Merge slight left onto McDermott Freeway
12.8 mi · 15 min · McDermott Freeway
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11
Keep slight right
98.7 mi · 1 hr 37 min
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12
Take the exit slight right toward US 83 North, US 377: Junction, Menard
1665 ft · 44 sec
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13
Turn right onto North Main Street
29.3 mi · 31 min · North Main Street
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14
Continue on Frisco Avenue
41.9 mi · 45 min · Frisco Avenue
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15
Continue on Roberts Avenue
16.5 mi · 18 min · Roberts Avenue
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16
Turn right onto Hutchings Avenue
118 m · 18 sec · Hutchings Avenue
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17
Turn left onto North Broadway Street
6.3 mi · 7 min · North Broadway Street
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18
Turn right
12.3 mi · 13 min
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19
Turn left onto State Highway 153
29.5 mi · 33 min · State Highway 153
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20
Keep slight right to continue on State Highway 153
6 m · 1 sec · State Highway 153
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21
Turn right onto State Highway 70
10.4 mi · 11 min · State Highway 70
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22
Continue on Lamar Street
1.3 km · 1 min · Lamar Street
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23
Turn left onto Northwest Georgia Avenue
670 ft · 17 sec · Northwest Georgia Avenue
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24
Take the ramp slight left toward I 20 West: Midland
104 m · 8 sec
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25
Merge slight left
6 mi · 6 min
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26
Take the exit slight right toward US 84 West: Snyder, Lubbock
1721 ft · 20 sec
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27
Keep slight left
74.2 mi · 1 hr 14 min
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28
Turn right onto South Avenue F
1 mi · 2 min · South Avenue F
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29
Keep slight left to continue on North Avenue F
617 ft · 11 sec · North Avenue F
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30
Turn straight onto Ralls Road
1863 ft · 39 sec · Ralls Road
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31
Turn left onto East 15th Street
734 ft · 17 sec · East 15th Street
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32
Turn right onto North US Highway 84
1 mi · 1 min · North US Highway 84
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33
Continue on Highway 84
20 mi · 20 min · Highway 84
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34
Continue on Trooper Jerry Don Davis Memorial Highway
4.6 mi · 5 min · Trooper Jerry Don Davis Memorial Highway
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35
Continue on East Highway 84
6.8 mi · 7 min · East Highway 84
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36
Continue on Slaton Road
4.9 mi · 6 min · Slaton Road
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37
Continue on Avenue Q South Drive
4 mi · 5 min · Avenue Q South Drive
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38
Turn left onto Clovis Road
6 mi · 7 min · Clovis Road
-
39
Continue on Highway 84
11.4 mi · 11 min · Highway 84
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40
Continue on US Highway 84
24.5 mi · 25 min · US Highway 84
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41
Continue straight
8 mi · 8 min
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42
Continue straight
17.8 mi · 18 min
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43
Turn right onto North 1st Street
20 m · 2 sec · North 1st Street
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44
Arrive at your destination
0 m · 1 sec · North 1st Street
Car Route Details
A richer read on the saved driving route between San Antonio and Muleshoe.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
McDermott Freeway
Keep slight right
98.7 mi · 01h 37m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Chance Showers And Thunderstorms then Slight Chance Showers And Thunderstorms leaving San Antonio and Sunny near Muleshoe.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from San Antonio to Muleshoe?
The road trip is about 453.4 miles (729.7 km) and usually takes 07h 56m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Winters is a useful midpoint, sitting about 226.9 miles from San Antonio and 226.5 miles from Muleshoe.
How much longer is the road route than the straight-line distance?
The direct path is about 414.3 miles (666.8 km), while the road route adds roughly 39.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $60.46 one way or $120.93 round trip. Estimated CO2 is about 142.2 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms then Slight Chance Showers And Thunderstorms around San Antonio and Sunny near Muleshoe.
Flight Path Map
This map shows the direct air route between San Antonio and Muleshoe. Straight-line distance: 414.35 mi (666.83 km).
#1 San Antonio
The seventh most populous city in the United States and the center of the San Antonio metropolitan area.
| Population | 1,567,118 |
| Coordinates | 29.4241200, -98.4936300 |
| Altitude | 198 |
| Country | United States |
#2 Muleshoe
City in Texas, USA
| Population | 4,822 |
| Coordinates | 34.2264700, -102.7238300 |
| Altitude | 1156 |
| Country | United States |
End: Muleshoe (-102.72383, 34.22647)
Estimated Travel Time
Distance: 730 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 15h 06m |
| 40 mph (64.37 km/h) | 11h 20m |
| 50 mph (80.47 km/h) | 09h 04m |
| 60 mph (96.56 km/h) | 07h 33m |
| 70 mph (112.65 km/h) | 06h 28m |
| 80 mph (129 km/h) | 05h 39m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.78 | $60.46 | $120.93 |
| Mid-grade | $4.25 | $68.03 | $136.06 |
| Premium | $4.59 | $73.46 | $146.91 |
| Diesel | $3.99 | $63.89 | $127.78 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.