How far is Mount Pleasant, SC from Greenville, TN?
The driving distance from Mount Pleasant, SC to Greenville, TN is about 566.5 miles (911.7 km), with a travel time of about 10h 43m by car.
- The straight-line flight distance is about 467.2 miles (751.9 km).
- For a round trip, plan for roughly 21h 26m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EST.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 10h 43m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Haywood County, North Carolina, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Patchy Frost then Sunny
Driving Route Map
The map below follows the saved road route between Mount Pleasant and Greenville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mount Pleasant and Greenville.
-
1
Start on the route
23 m · 10 sec
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2
Turn right onto Coleman Boulevard
72 m · 10 sec · Coleman Boulevard
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3
Turn left onto Chuck Dawley Boulevard
1.3 mi · 2 min · Chuck Dawley Boulevard
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4
Turn straight onto Mark Clark Expressway
12 mi · 15 min · Mark Clark Expressway
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5
Take the exit slight right toward US 52 West, US 78 West: Rivers Avenue
1271 ft · 31 sec
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6
Turn slight right onto Rivers Avenue
1.1 mi · 2 min · Rivers Avenue
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7
Turn straight
534 ft · 21 sec
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8
Take the ramp slight right toward I 26 North: Columbia
2641 ft · 45 sec
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9
Merge slight left
158.7 mi · 2 hr 53 min
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10
Keep slight right to continue on Spartanburg
91.4 mi · 1 hr 43 min
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11
Take the exit slight left toward I 40 West, US 74: Canton, Knoxville
129.8 mi · 2 hr 35 min
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12
Keep slight right to continue on Nashville
148.9 mi · 2 hr 40 min
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13
Take the exit slight right toward Stewarts Ferry Pike, J Percy Priest Dam
2298 ft · 57 sec
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14
Turn right onto Stewarts Ferry Pike
1.7 mi · 3 min · Stewarts Ferry Pike
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15
Turn left onto Lebanon Pike
1.7 mi · 3 min · Lebanon Pike
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16
Take the ramp slight right toward SR 155 North: Briley Parkway, Opryland
1760 ft · 43 sec
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17
Merge slight left onto Briley Parkway
12.1 mi · 14 min · Briley Parkway
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18
Take the exit slight right toward US 41A North: Clarksville Pike
1498 ft · 37 sec
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19
Turn slight right onto Clarksville Highway
5.9 mi · 9 min · Clarksville Highway
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20
Turn left onto Bernard Road
15 m · 2 sec · Bernard Road
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21
Arrive at your destination
0 m · 1 sec · Bernard Road
Car Route Details
A richer read on the saved driving route between Mount Pleasant and Greenville.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 26 North
Merge slight left
159 mi · 02h 53m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Mount Pleasant and Patchy Frost then Sunny near Greenville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mount Pleasant to Greenville?
The road trip is about 566.5 miles (911.7 km) and usually takes 10h 43m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Clyde is a useful midpoint, sitting about 283.2 miles from Mount Pleasant and 283.3 miles from Greenville.
How much longer is the road route than the straight-line distance?
The direct path is about 467.2 miles (751.9 km), while the road route adds roughly 99.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EST. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $71.32 one way or $142.65 round trip. Estimated CO2 is about 177.7 kg one way.
Do you cross a time zone on this route?
Yes. There is about a 1 hour time difference between Mount Pleasant and Greenville, so arrival and return times should be read in local time.
What should you check before leaving?
Before you leave, expect Sunny around Mount Pleasant and Patchy Frost then Sunny near Greenville.
Stop Ideas Near Clyde
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Clyde.
Greenville
Clemson
Spartanburg
Toccoa
Flight Path Map
This map shows the direct air route between Mount Pleasant and Greenville. Straight-line distance: 467.18 mi (751.86 km).
#1 Mount Pleasant
The second most populous city in Charleston County, South Carolina.
| Population | 92,799 |
| Coordinates | 32.7940700, -79.8625900 |
| Altitude | 3 |
| Country | United States |
#2 Greenville
Greenville is a place in Tennessee, United States.
| Population | 0 |
| Coordinates | 36.2970000, -86.8883300 |
| Altitude | 254 |
| Country | United States |
End: Greenville (-86.88833, 36.297)
Estimated Travel Time
Distance: 912 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 18h 52m |
| 40 mph (64.37 km/h) | 14h 09m |
| 50 mph (80.47 km/h) | 11h 19m |
| 60 mph (96.56 km/h) | 09h 26m |
| 70 mph (112.65 km/h) | 08h 05m |
| 80 mph (129 km/h) | 07h 04m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.57 | $71.32 | $142.65 |
| Mid-grade | $4.01 | $80.24 | $160.48 |
| Premium | $4.42 | $88.40 | $176.79 |
| Diesel | $5.69 | $113.80 | $227.61 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in South Carolina · Nov 07, 2026