How far is Mequon, WI from La Crosse, WI?
The driving distance from Mequon, WI to La Crosse, WI is about 220 miles (354 km), with a travel time of about 03h 28m by car.
- The straight-line flight distance is about 165.8 miles (266.9 km).
- For a round trip, plan for roughly 06h 56m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 28m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Fourth-class city in Columbia County, Wisconsin
Route Weather Snapshot
Check the forecast at both ends before you head out.
Slight Chance Showers And Thunderstorms then Showers And Thunderstorms Likely
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Mequon and La Crosse.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mequon and La Crosse.
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1
Start on the route
569 ft · 44 sec
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2
At the end of the road, turn right onto North Swan Road
1.8 mi · 3 min · North Swan Road
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3
Turn right onto West County Line Road
1 mi · 2 min · West County Line Road
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4
Turn left onto North 107th Street
1.4 km · 2 min · North 107th Street
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5
Turn right onto West Brown Deer Road
1 mi · 2 min · West Brown Deer Road
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6
Turn left onto North 124th Street
1.3 mi · 2 min · North 124th Street
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7
Take the ramp left toward I 41 South, US 45
1940 ft · 53 sec
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8
Merge slight left onto Zoo Freeway
4.5 mi · 6 min · Zoo Freeway
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9
Take the exit slight right toward WI 190, I 94 West Alternate: Capitol Drive
649 ft · 16 sec
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10
Keep slight right to continue on WI 190 East
1183 ft · 40 sec
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11
Turn straight onto West Capitol Drive
7.1 mi · 11 min · West Capitol Drive
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12
Turn slight right
1401 ft · 51 sec
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13
Keep slight left
63 m · 10 sec
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14
Turn left onto Redford Boulevard
2.5 mi · 4 min · Redford Boulevard
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15
Take the ramp slight right
1793 ft · 44 sec
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16
Merge slight left onto East-West Freeway
1.3 mi · 1 min · East-West Freeway
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17
Keep slight left to continue on East-West Freeway
53.5 mi · 57 min · East-West Freeway
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18
Keep slight right to continue on I 39 North, I 90 West, I 94 West: Wisconsin Dells, Eau Claire
29.1 mi · 31 min
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19
Keep slight left
63.5 mi · 1 hr 8 min
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20
Keep slight left to continue on I 90 West: Tomah, La Crosse
39.1 mi · 42 min
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21
Take the exit slight right toward WI 16: La Crosse, Onalaska
1636 ft · 42 sec
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22
At the end of the road, turn left
4.9 mi · 9 min
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23
Continue on Losey Boulevard North
2575 ft · 2 min · Losey Boulevard North
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24
Turn right onto Main Street
1.1 km · 2 min · Main Street
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25
Turn left onto 16th Street South
1.3 km · 2 min · 16th Street South
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26
Turn right onto Johnson Street
1824 ft · 1 min · Johnson Street
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27
At the end of the road, turn right onto West Avenue South
99 m · 11 sec · West Avenue South
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28
Arrive at your destination
0 m · 1 sec · West Avenue South
Car Route Details
A richer read on the saved driving route between Mequon and La Crosse.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 39 North
Keep slight left
63.5 mi · 01h 08m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Slight Chance Showers And Thunderstorms then Showers And Thunderstorms Likely leaving Mequon and Chance Showers And Thunderstorms near La Crosse.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mequon to La Crosse?
The road trip is about 220 miles (354 km) and usually takes 03h 28m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Portage is a useful midpoint, sitting about 107.6 miles from Mequon and 112.3 miles from La Crosse.
How much longer is the road route than the straight-line distance?
The direct path is about 165.8 miles (266.9 km), while the road route adds roughly 54.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:04 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $29.26 one way or $58.53 round trip. Estimated CO2 is about 69 kg one way.
What should you check before leaving?
Before you leave, expect Slight Chance Showers And Thunderstorms then Showers And Thunderstorms Likely around Mequon and Chance Showers And Thunderstorms near La Crosse.
Stop Ideas Near Portage
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Portage.
Portage
Wisconsin Dells
Westfield, WI
Columbus
Flight Path Map
This map shows the direct air route between Mequon and La Crosse. Straight-line distance: 165.84 mi (266.89 km).
#1 Mequon
Fourth-class city in Ozaukee County, Wisconsin
| Population | 24,765 |
| Coordinates | 43.2155500, -88.0300100 |
| Altitude | 204 |
| Country | United States |
#2 La Crosse
The most populous city in La Crosse County, Wisconsin.
| Population | 51,163 |
| Coordinates | 43.8013600, -91.2395800 |
| Altitude | 204 |
| Country | United States |
End: West Avenue South (-91.239623, 43.801338)
Estimated Travel Time
Distance: 354 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 19m |
| 40 mph (64.37 km/h) | 05h 29m |
| 50 mph (80.47 km/h) | 04h 23m |
| 60 mph (96.56 km/h) | 03h 39m |
| 70 mph (112.65 km/h) | 03h 08m |
| 80 mph (129 km/h) | 02h 44m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $29.26 | $58.53 |
| Mid-grade | $4.25 | $33.00 | $66.01 |
| Premium | $4.65 | $36.12 | $72.23 |
| Diesel | $5.30 | $41.16 | $82.32 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Wisconsin · May 18, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.