How far is Lake City, SC from Greenville, SC?
The driving distance from Lake City, SC to Greenville, SC is about 192.6 miles (310 km), with a travel time of about 03h 02m by car.
- The straight-line flight distance is about 165 miles (265.6 km).
- For a round trip, plan for roughly 06h 05m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 02m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Lake City and Greenville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Lake City and Greenville.
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1
Start on South Acline Avenue
732 ft · 20 sec · South Acline Avenue
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2
Turn left onto West Main Street
2.5 mi · 4 min · West Main Street
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3
At the end of the road, turn left
13.4 mi · 17 min
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4
Turn slight right onto Clarence Coker Highway
3.5 mi · 5 min · Clarence Coker Highway
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5
Continue on Myrtle Beach Highway
13 mi · 17 min · Myrtle Beach Highway
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6
Keep slight right to continue on Robert E Graham Freeway
6.4 mi · 7 min · Robert E Graham Freeway
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7
Merge slight left onto Broad Street
36.2 mi · 46 min · Broad Street
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8
Continue on Devine Street
1284 ft · 32 sec · Devine Street
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9
Continue on Devine Street
1.1 mi · 2 min · Devine Street
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10
Turn slight right onto Millwood Avenue
1.8 mi · 4 min · Millwood Avenue
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11
Turn left onto Taylor Street
1.5 km · 2 min · Taylor Street
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12
Turn right onto Bull Street
2589 ft · 1 min · Bull Street
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13
Turn left onto Elmwood Avenue
1.5 km · 2 min · Elmwood Avenue
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14
Continue straight
3.8 mi · 5 min
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15
Merge slight left
55.7 mi · 1 hr 1 min
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16
Keep slight left to continue on I 385 North: Laurens, Greenville
29.6 mi · 32 min
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17
Keep slight left to continue on Golden Strip Freeway
12.4 mi · 15 min · Golden Strip Freeway
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18
Continue on East North Street
1270 ft · 19 sec · East North Street
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19
Continue on Beattie Place
1231 ft · 27 sec · Beattie Place
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20
Turn right onto North Church Street
18 m · 2 sec · North Church Street
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21
Arrive at your destination
0 m · 1 sec · North Church Street
Car Route Details
A richer read on the saved driving route between Lake City and Greenville.
Straightforward drive
The saved road route has a manageable number of maneuvers and should be easy to follow with normal attention to signs.
Elmwood Avenue
Merge slight left
55.7 mi · 01h 01m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Lake City and Mostly Sunny near Greenville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Lake City to Greenville?
The road trip is about 192.6 miles (310 km) and usually takes 03h 02m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Irmo is a useful midpoint, sitting about 91.2 miles from Lake City and 101.5 miles from Greenville.
How much longer is the road route than the straight-line distance?
The direct path is about 165 miles (265.6 km), while the road route adds roughly 27.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 10:54 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $26.93 one way or $53.87 round trip. Estimated CO2 is about 60.4 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Lake City and Mostly Sunny near Greenville.
Stop Ideas Near Irmo
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Irmo.
Columbia
Camden
Denmark
Spartanburg
Flight Path Map
This map shows the direct air route between Lake City and Greenville. Straight-line distance: 165.07 mi (265.65 km).
#1 Lake City
City in South Carolina, USA
| Population | 6,497 |
| Coordinates | 33.8710000, -79.7553500 |
| Altitude | 23 |
| Country | United States |
#2 Greenville
The most populous city in Greenville County, South Carolina.
| Population | 72,227 |
| Coordinates | 34.8526200, -82.3940100 |
| Altitude | 307 |
| Country | United States |
End: North Church Street (-82.394165, 34.852668)
Estimated Travel Time
Distance: 310 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 25m |
| 40 mph (64.37 km/h) | 04h 48m |
| 50 mph (80.47 km/h) | 03h 51m |
| 60 mph (96.56 km/h) | 03h 12m |
| 70 mph (112.65 km/h) | 02h 45m |
| 80 mph (129 km/h) | 02h 24m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.96 | $26.93 | $53.87 |
| Mid-grade | $4.43 | $30.12 | $60.23 |
| Premium | $4.78 | $32.49 | $64.98 |
| Diesel | $5.62 | $38.24 | $76.49 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in South Carolina · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.