How far is Jacksonville, FL from Mayo, FL?
The driving distance from Jacksonville, FL to Mayo, FL is about 106.3 miles (171 km), with a travel time of about 02h 07m by car.
- The straight-line flight distance is about 92.8 miles (149.3 km).
- For a round trip, plan for roughly 04h 14m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM EDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 07m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
County seat of Columbia County, Florida, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Cloudy
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Jacksonville and Mayo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Jacksonville and Mayo.
-
1
Start on Union Street
64 m · 13 sec · Union Street
-
2
Turn left onto Ocean Street
86 m · 15 sec · Ocean Street
-
3
Turn left onto State Street
1.1 km · 2 min · State Street
-
4
Continue on Kings Road
1331 ft · 37 sec · Kings Road
-
5
Take the ramp slight left toward I 95 South: Jacksonville
1.1 mi · 2 min
-
6
Take the exit slight right toward I 10 West: Lake City
1.2 km · 2 min
-
7
Merge slight left
78.6 mi · 1 hr 26 min
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8
Take the exit slight right toward US 129: Live Oak, Jasper
1584 ft · 40 sec
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9
Turn left onto US Highway 129
2.1 mi · 4 min · US Highway 129
-
10
Turn right onto Winderweedle Street Northwest
1699 ft · 49 sec · Winderweedle Street Northwest
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11
At the end of the road, turn left
2777 ft · 1 min
-
12
Continue on Houston Avenue Southwest
3202 ft · 1 min · Houston Avenue Southwest
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13
At the end of the road, turn right onto 11th Street Southwest
927 ft · 23 sec · 11th Street Southwest
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14
Enter the roundabout and take exit 3 toward Irvin Avenue
75 m · 6 sec · Irvin Avenue
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15
Exit the roundabout onto Irvin Avenue
20.7 mi · 27 min · Irvin Avenue
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16
Turn left onto Main Street
43 m · 4 sec · Main Street
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17
Arrive at your destination
0 m · 1 sec · Main Street
Car Route Details
A richer read on the saved driving route between Jacksonville and Mayo.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 10 West
Merge slight left
78.6 mi · 01h 26m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Partly Cloudy leaving Jacksonville and Chance Showers And Thunderstorms near Mayo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Jacksonville to Mayo?
The road trip is about 106.3 miles (171 km) and usually takes 02h 07m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Lake City is a useful midpoint, sitting about 53.1 miles from Jacksonville and 53.2 miles from Mayo.
How much longer is the road route than the straight-line distance?
The direct path is about 92.8 miles (149.3 km), while the road route adds roughly 13.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM EDT. If you want a more comfortable same-day return, try to leave by 2:16 PM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $15.56 one way or $31.11 round trip. Estimated CO2 is about 33.3 kg one way.
What should you check before leaving?
Before you leave, expect Partly Cloudy around Jacksonville and Chance Showers And Thunderstorms near Mayo.
Stop Ideas Near Lake City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Lake City.
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Flight Path Map
This map shows the direct air route between Jacksonville and Mayo. Straight-line distance: 92.75 mi (149.27 km).
#1 Jacksonville
The thirteenth most populous city in the United States and the center of the Jacksonville metropolitan area.
| Population | 920,570 |
| Coordinates | 30.3321800, -81.6556500 |
| Altitude | 5 |
| Country | United States |
#2 Mayo
Municipality in Lafayette, Florida, USA
| Population | 1,289 |
| Coordinates | 30.0530000, -83.1748600 |
| Altitude | 27 |
| Country | United States |
End: Mayo (-83.17486, 30.053)
Estimated Travel Time
Distance: 171 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 03h 32m |
| 40 mph (64.37 km/h) | 02h 39m |
| 50 mph (80.47 km/h) | 02h 07m |
| 60 mph (96.56 km/h) | 01h 46m |
| 70 mph (112.65 km/h) | 01h 31m |
| 80 mph (129 km/h) | 01h 19m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $15.56 | $31.11 |
| Mid-grade | $4.60 | $17.24 | $34.47 |
| Premium | $4.90 | $18.36 | $36.72 |
| Diesel | $4.35 | $16.31 | $32.63 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 26, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.