How far is Isle of Palms, SC from Greenville, SC?
The driving distance from Isle of Palms, SC to Greenville, SC is about 221.1 miles (355.9 km), with a travel time of about 03h 27m by car.
- The straight-line flight distance is about 206.5 miles (332.3 km).
- For a round trip, plan for roughly 06h 55m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 27m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in South Carolina
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Isle of Palms and Greenville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Isle of Palms and Greenville.
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1
Start on Palm Boulevard
2128 ft · 53 sec · Palm Boulevard
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2
Turn left onto Isle of Palms Connector
3.6 mi · 6 min · Isle of Palms Connector
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3
Turn left onto Hungry Neck Boulevard
1.3 mi · 2 min · Hungry Neck Boulevard
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4
Keep slight left
1.3 km · 2 min
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5
Merge slight left onto Mark Clark Expressway
11 mi · 13 min · Mark Clark Expressway
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6
Take the exit slight right toward US 52 West, US 78 West: Rivers Avenue
1271 ft · 31 sec
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7
Turn slight right onto Rivers Avenue
1.1 mi · 2 min · Rivers Avenue
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8
Turn straight
534 ft · 21 sec
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9
Take the ramp slight right toward I 26 North: Columbia
2641 ft · 45 sec
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10
Merge slight left
158.7 mi · 2 hr 53 min
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11
Keep slight left to continue on I 385 North: Laurens, Greenville
29.6 mi · 32 min
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12
Keep slight left to continue on Golden Strip Freeway
12.4 mi · 15 min · Golden Strip Freeway
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13
Continue on East North Street
1270 ft · 19 sec · East North Street
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14
Continue on Beattie Place
1231 ft · 27 sec · Beattie Place
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15
Turn right onto North Church Street
18 m · 2 sec · North Church Street
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16
Arrive at your destination
0 m · 1 sec · North Church Street
Car Route Details
A richer read on the saved driving route between Isle of Palms and Greenville.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 26 North
Merge slight left
159 mi · 02h 53m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Isle of Palms and Chance Showers And Thunderstorms near Greenville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Isle of Palms to Greenville?
The road trip is about 221.1 miles (355.9 km) and usually takes 03h 27m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Pineridge is a useful midpoint, sitting about 110.2 miles from Isle of Palms and 111 miles from Greenville.
How much longer is the road route than the straight-line distance?
The direct path is about 206.5 miles (332.3 km), while the road route adds roughly 14.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 10:04 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $30.90 one way or $61.79 round trip. Estimated CO2 is about 69.3 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Isle of Palms and Chance Showers And Thunderstorms near Greenville.
Stop Ideas Near Pineridge
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Pineridge.
Columbia
Camden
Denmark
Flight Path Map
This map shows the direct air route between Isle of Palms and Greenville. Straight-line distance: 206.46 mi (332.27 km).
#1 Isle of Palms
City in Charleston County, South Carolina, United States
| Population | 4,371 |
| Coordinates | 32.7868400, -79.7948000 |
| Altitude | 1 |
| Country | United States |
#2 Greenville
The most populous city in Greenville County, South Carolina.
| Population | 72,227 |
| Coordinates | 34.8526200, -82.3940100 |
| Altitude | 307 |
| Country | United States |
End: North Church Street (-82.394165, 34.852668)
Estimated Travel Time
Distance: 356 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 22m |
| 40 mph (64.37 km/h) | 05h 31m |
| 50 mph (80.47 km/h) | 04h 25m |
| 60 mph (96.56 km/h) | 03h 41m |
| 70 mph (112.65 km/h) | 03h 09m |
| 80 mph (129 km/h) | 02h 45m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.96 | $30.90 | $61.79 |
| Mid-grade | $4.43 | $34.55 | $69.09 |
| Premium | $4.78 | $37.27 | $74.54 |
| Diesel | $5.62 | $43.87 | $87.73 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in South Carolina · May 06, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.