How far is Hannibal, MO from Cape Girardeau, MO?
The driving distance from Hannibal, MO to Cape Girardeau, MO is about 220.9 miles (355.5 km), with a travel time of about 03h 32m by car.
- The straight-line flight distance is about 193.5 miles (311.4 km).
- For a round trip, plan for roughly 07h 04m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 32m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Saint Louis County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Hannibal and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between Hannibal and Cape Girardeau.
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1
Start on the route
17 m · 9 sec
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2
Turn left onto Broadway
3145 ft · 1 min · Broadway
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3
Turn left onto Grand Avenue
1072 ft · 24 sec · Grand Avenue
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4
Turn right onto Warren Barett Drive
3 mi · 5 min · Warren Barett Drive
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5
Turn left onto Avenue of the Saints
98.1 mi · 1 hr 57 min · Avenue of the Saints
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6
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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7
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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8
Merge slight left
11.5 mi · 14 min
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9
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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10
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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11
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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12
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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13
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 1 hr 40 min · Police Officer Steven Jarvis Memorial Highway
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14
Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
814 ft · 17 sec
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15
Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau
1354 ft · 29 sec
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16
Continue on North Kingshighway
3.6 mi · 6 min · North Kingshighway
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17
Turn left onto Broadway Street
2 mi · 4 min · Broadway Street
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18
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between Hannibal and Cape Girardeau.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Avenue of the Saints
Turn left onto Avenue of the Saints
98.1 mi · 01h 57m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Hannibal and Mostly Sunny near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Hannibal to Cape Girardeau?
The road trip is about 220.9 miles (355.5 km) and usually takes 03h 32m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Sunset Hills is a useful midpoint, sitting about 108.7 miles from Hannibal and 112.2 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 193.5 miles (311.4 km), while the road route adds roughly 27.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 9:56 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $29.41 one way or $58.83 round trip. Estimated CO2 is about 69.3 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Hannibal and Mostly Sunny near Cape Girardeau.
Stop Ideas Near Sunset Hills
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Sunset Hills.
Kirkwood
Gateway Transportation Center
Alton
Washington
Flight Path Map
This map shows the direct air route between Hannibal and Cape Girardeau. Straight-line distance: 193.52 mi (311.44 km).
#1 Hannibal
City in Missouri, USA
| Population | 17,246 |
| Coordinates | 39.7083800, -91.3584800 |
| Altitude | 153 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 356 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 21m |
| 40 mph (64.37 km/h) | 05h 31m |
| 50 mph (80.47 km/h) | 04h 25m |
| 60 mph (96.56 km/h) | 03h 40m |
| 70 mph (112.65 km/h) | 03h 09m |
| 80 mph (129 km/h) | 02h 45m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $29.41 | $58.83 |
| Mid-grade | $4.25 | $33.17 | $66.35 |
| Premium | $4.65 | $36.30 | $72.60 |
| Diesel | $5.30 | $41.37 | $82.74 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 01, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.