How far is Greenville, SC from Murrells Inlet, SC?
The driving distance from Greenville, SC to Murrells Inlet, SC is about 249 miles (400.8 km), with a travel time of about 05h 05m by car.
- The straight-line flight distance is about 211.6 miles (340.6 km).
- For a round trip, plan for roughly 10h 11m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 05m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Richland County, South Carolina, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Greenville and Murrells Inlet.
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenville and Murrells Inlet.
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1
Start on North Church Street
151 m · 21 sec · North Church Street
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2
Turn left onto East North Street
2612 ft · 43 sec · East North Street
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3
Continue straight
10.5 mi · 13 min
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4
Keep slight left to continue on Golden Strip Freeway
31.6 mi · 35 min · Golden Strip Freeway
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5
Merge slight left
55.8 mi · 1 hr 1 min
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6
Keep slight left to continue on I 126, US 76: Columbia
3.4 mi · 4 min
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7
Take the exit slight right toward Huger Street
1161 ft · 28 sec
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8
Continue on Huger Street
1.2 km · 2 min · Huger Street
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9
Turn left onto Gervais Street
1.9 mi · 4 min · Gervais Street
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10
Turn right onto Millwood Avenue
1.4 mi · 3 min · Millwood Avenue
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11
Continue on Devine Street
1.3 mi · 3 min · Devine Street
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12
Continue on Garners Ferry Road
36.2 mi · 46 min · Garners Ferry Road
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13
Keep slight right to continue on Broad Street
1.1 mi · 2 min · Broad Street
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14
Turn slight right onto Bultman Drive
1.2 km · 2 min · Bultman Drive
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15
Continue on North Guignard Drive
3.6 mi · 4 min · North Guignard Drive
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16
Continue on South Guignard Parkway
1.1 mi · 1 min · South Guignard Parkway
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17
Turn right onto Manning Road
15.1 mi · 17 min · Manning Road
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18
Continue on North Church Street
1.1 km · 51 sec · North Church Street
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19
Turn left onto East Boyce Street
2023 ft · 57 sec · East Boyce Street
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20
Continue on Greeleyville Highway
14.2 mi · 16 min · Greeleyville Highway
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21
Continue on Society Street
2787 ft · 40 sec · Society Street
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22
Continue on Society Street
1.2 km · 53 sec · Society Street
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23
Continue on US Highway 521
26.8 mi · 30 min · US Highway 521
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24
Continue on West Main Street
1.9 mi · 3 min · West Main Street
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25
Continue on Georgetown Highway
7.7 mi · 9 min · Georgetown Highway
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26
Continue on Highmarket Street
9.4 mi · 13 min · Highmarket Street
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27
Keep slight left to continue on Church Street
1.5 mi · 3 min · Church Street
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28
Continue on L. H. Siau Bridge
1340 ft · 25 sec · L. H. Siau Bridge
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29
Continue on Ocean Highway
17.4 mi · 25 min · Ocean Highway
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30
Continue on Highway 17
1.8 mi · 2 min · Highway 17
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31
Turn right onto Wachesaw Road
1253 ft · 40 sec · Wachesaw Road
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32
At the end of the road, turn left onto US 17 Business
1660 ft · 57 sec · US 17 Business
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33
Arrive at your destination
0 m · 1 sec · US 17 Business
Car Route Details
A richer read on the saved driving route between Greenville and Murrells Inlet.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Golden Strip Freeway
Merge slight left
55.8 mi · 01h 01m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Showers And Thunderstorms leaving Greenville and Showers And Thunderstorms near Murrells Inlet.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Greenville to Murrells Inlet?
The road trip is about 249 miles (400.8 km) and usually takes 05h 05m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Eastover is a useful midpoint, sitting about 124.5 miles from Greenville and 124.6 miles from Murrells Inlet.
How much longer is the road route than the straight-line distance?
The direct path is about 211.6 miles (340.6 km), while the road route adds roughly 37.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 6:48 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $34.82 one way or $69.63 round trip. Estimated CO2 is about 78.1 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Greenville and Showers And Thunderstorms near Murrells Inlet.
Stop Ideas Near Eastover
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Eastover.
Columbia
Camden
Denmark
Kingstree
Flight Path Map
This map shows the direct air route between Greenville and Murrells Inlet. Straight-line distance: 211.62 mi (340.57 km).
#1 Greenville
The most populous city in Greenville County, South Carolina.
| Population | 72,227 |
| Coordinates | 34.8526200, -82.3940100 |
| Altitude | 307 |
| Country | United States |
#2 Murrells Inlet
Town in Georgetown County and Horry County, South Carolina, United States
| Population | 7,547 |
| Coordinates | 33.5510000, -79.0414300 |
| Altitude | 1 |
| Country | United States |
End: Murrells Inlet (-79.04143, 33.551)
Estimated Travel Time
Distance: 401 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 08h 17m |
| 40 mph (64.37 km/h) | 06h 13m |
| 50 mph (80.47 km/h) | 04h 58m |
| 60 mph (96.56 km/h) | 04h 09m |
| 70 mph (112.65 km/h) | 03h 33m |
| 80 mph (129 km/h) | 03h 06m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.96 | $34.82 | $69.63 |
| Mid-grade | $4.43 | $38.93 | $77.86 |
| Premium | $4.78 | $42.00 | $84.00 |
| Diesel | $5.62 | $49.43 | $98.87 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in South Carolina · May 02, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.