How far is East Palo Alto, CA from Santa Ana, CA?
The driving distance from East Palo Alto, CA to Santa Ana, CA is about 388.8 miles (625.7 km), with a travel time of about 06h 35m by car.
- The straight-line flight distance is about 351.8 miles (566.1 km).
- For a round trip, plan for roughly 13h 11m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM PDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 35m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Kings County, California
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between East Palo Alto and Santa Ana.
Turn-by-Turn Driving Directions
Step-by-step road directions between East Palo Alto and Santa Ana.
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1
Start on University Avenue
1160 ft · 48 sec · University Avenue
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2
Continue on University Avenue
1.5 km · 3 min · University Avenue
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3
Turn left onto US 101 South: San Jose
1523 ft · 41 sec
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4
Merge slight left onto Bayshore Freeway
4.7 mi · 5 min · Bayshore Freeway
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5
Keep slight left to continue on Bayshore Freeway
42.4 mi · 49 min · Bayshore Freeway
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6
Take the exit slight right toward CA 152 East: 10th Street, Pacheco Pass Road
1539 ft · 40 sec
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7
Turn left onto East 10th Street
108 m · 13 sec · East 10th Street
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8
Continue on Pacheco Pass Highway
40.6 mi · 50 min · Pacheco Pass Highway
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9
Take the exit slight right toward I 5: Los Angeles
3148 ft · 1 min
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10
Merge slight left onto Westside Freeway
181.1 mi · 3 hr 14 min · Westside Freeway
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11
Keep slight right
58.4 mi · 1 hr 7 min
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12
Keep slight left to continue on Golden State Freeway
4.1 mi · 5 min · Golden State Freeway
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13
Keep slight right to continue on I 405 South
1354 ft · 18 sec
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14
Keep slight left
24.7 mi · 29 min
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15
Keep slight left to continue on Golden State Freeway
1.3 mi · 2 min · Golden State Freeway
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16
Merge slight left onto Santa Ana Freeway
25.7 mi · 30 min · Santa Ana Freeway
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17
Keep slight right to continue on Santa Ana Freeway
1241 ft · 16 sec · Santa Ana Freeway
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18
Take the exit slight right toward Broadway, Main Street, Santa Ana
1.3 km · 57 sec
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19
Keep slight right to continue on Main Street North, Broadway
1656 ft · 22 sec
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20
Turn straight onto North Broadway
1.3 mi · 3 min · North Broadway
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21
Turn left onto West 5th Street
639 ft · 17 sec · West 5th Street
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22
Turn right onto North Main Street
1209 ft · 31 sec · North Main Street
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23
Turn right onto West 1st Street
16 m · 1 sec · West 1st Street
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24
Arrive at your destination
0 m · 1 sec · West 1st Street
Car Route Details
A richer read on the saved driving route between East Palo Alto and Santa Ana.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Westside Freeway
Merge slight left onto Westside Freeway
181 mi · 03h 14m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving East Palo Alto and Mostly Sunny near Santa Ana.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from East Palo Alto to Santa Ana?
The road trip is about 388.8 miles (625.7 km) and usually takes 06h 35m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Kettleman City is a useful midpoint, sitting about 194.4 miles from East Palo Alto and 194.4 miles from Santa Ana.
How much longer is the road route than the straight-line distance?
The direct path is about 351.8 miles (566.1 km), while the road route adds roughly 37 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM PDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $79.15 one way or $158.30 round trip. Estimated CO2 is about 121.9 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around East Palo Alto and Mostly Sunny near Santa Ana.
Stop Ideas Near Kettleman City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kettleman City.
Kettleman City, California
Lemoore, California
Corcoran station
Lemoore (Naval Air Station), California
Flight Path Map
This map shows the direct air route between East Palo Alto and Santa Ana. Straight-line distance: 351.77 mi (566.12 km).
#1 East Palo Alto
City in San Mateo County, California, United States
| Population | 29,059 |
| Coordinates | 37.4688300, -122.1410800 |
| Altitude | 6 |
| Country | United States |
#2 Santa Ana
The most populous city in Orange County, California and the center of the Santa Ana metropolitan area.
| Population | 331,301 |
| Coordinates | 33.7455700, -117.8678300 |
| Altitude | 35 |
| Country | United States |
End: West 1st Street (-117.86783, 33.745553)
Estimated Travel Time
Distance: 626 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 12h 57m |
| 40 mph (64.37 km/h) | 09h 43m |
| 50 mph (80.47 km/h) | 07h 46m |
| 60 mph (96.56 km/h) | 06h 28m |
| 70 mph (112.65 km/h) | 05h 33m |
| 80 mph (129 km/h) | 04h 51m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $5.77 | $79.15 | $158.30 |
| Mid-grade | $6.07 | $83.23 | $166.45 |
| Premium | $6.24 | $85.65 | $171.31 |
| Diesel | $7.57 | $103.82 | $207.64 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in California · Apr 18, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.