How far is Santa Ana, CA from East Palo Alto, CA?
The driving distance from Santa Ana, CA to East Palo Alto, CA is about 388.4 miles (625.1 km), with a travel time of about 07h 19m by car.
- The straight-line flight distance is about 351.8 miles (566.1 km).
- For a round trip, plan for roughly 14h 39m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM PDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 07h 19m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Kings County, California
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Santa Ana and East Palo Alto.
Turn-by-Turn Driving Directions
Step-by-step road directions between Santa Ana and East Palo Alto.
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1
Start on West 1st Street
576 ft · 16 sec · West 1st Street
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2
Turn right onto North Broadway
1.5 mi · 3 min · North Broadway
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3
Turn right onto West Santa Clara Avenue
615 ft · 14 sec · West Santa Clara Avenue
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4
Continue on I 5 North: Los Angeles
1787 ft · 27 sec
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5
Merge slight left onto Santa Ana Freeway
8.9 mi · 10 min · Santa Ana Freeway
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6
Keep slight right to continue on Santa Ana Freeway
18 mi · 21 min · Santa Ana Freeway
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7
Keep slight right to continue on Golden State Freeway
25.5 mi · 30 min · Golden State Freeway
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8
Keep slight left to continue on Golden State Freeway
2.2 mi · 3 min · Golden State Freeway
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9
Keep slight right to continue on I 5 Truck North, CA 14 Truck
1.5 mi · 2 min
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10
Keep slight left
36.1 mi · 42 min
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11
Keep slight left to continue on Golden State Freeway
22.3 mi · 25 min · Golden State Freeway
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12
Keep slight right to continue on Westside Freeway
182.5 mi · 3 hr 16 min · Westside Freeway
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13
Take the exit slight right toward CA 152 West: Gilroy, Hollister, San Jose
1038 ft · 27 sec
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14
Continue straight
28.7 mi · 33 min
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15
Keep slight right
11.9 mi · 17 min
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16
Take the exit slight right toward US 101 North: San Jose
2466 ft · 1 min
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17
Merge slight left onto South Valley Freeway
19.9 mi · 23 min · South Valley Freeway
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18
Keep slight left
21.9 mi · 25 min
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19
Keep slight left
5.4 mi · 6 min
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20
Take the exit slight right toward Palo Alto, East Palo Alto
157 m · 13 sec
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21
Keep slight right to continue on University Avenue, East Palo Alto
1097 ft · 34 sec
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22
Turn left onto Donohoe Street
108 m · 14 sec · Donohoe Street
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23
Turn right onto University Avenue
2271 ft · 1 min · University Avenue
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24
Arrive at your destination
0 m · 1 sec · University Avenue
Car Route Details
A richer read on the saved driving route between Santa Ana and East Palo Alto.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Westside Freeway
Keep slight right to continue on Westside Freeway
183 mi · 03h 16m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Mostly Sunny leaving Santa Ana and Sunny near East Palo Alto.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Santa Ana to East Palo Alto?
The road trip is about 388.4 miles (625.1 km) and usually takes 07h 19m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Kettleman City is a useful midpoint, sitting about 194.2 miles from Santa Ana and 194.2 miles from East Palo Alto.
How much longer is the road route than the straight-line distance?
The direct path is about 351.8 miles (566.1 km), while the road route adds roughly 36.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM PDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $79.09 one way or $158.19 round trip. Estimated CO2 is about 121.8 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Santa Ana and Sunny near East Palo Alto.
Stop Ideas Near Kettleman City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kettleman City.
Kettleman City, California
Lemoore, California
Corcoran station
Lemoore (Naval Air Station), California
Flight Path Map
This map shows the direct air route between Santa Ana and East Palo Alto. Straight-line distance: 351.77 mi (566.12 km).
#1 Santa Ana
The most populous city in Orange County, California and the center of the Santa Ana metropolitan area.
| Population | 331,301 |
| Coordinates | 33.7455700, -117.8678300 |
| Altitude | 35 |
| Country | United States |
#2 East Palo Alto
City in San Mateo County, California, United States
| Population | 29,059 |
| Coordinates | 37.4688300, -122.1410800 |
| Altitude | 6 |
| Country | United States |
End: East Palo Alto (-122.14108, 37.46883)
Estimated Travel Time
Distance: 625 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 12h 56m |
| 40 mph (64.37 km/h) | 09h 42m |
| 50 mph (80.47 km/h) | 07h 46m |
| 60 mph (96.56 km/h) | 06h 28m |
| 70 mph (112.65 km/h) | 05h 32m |
| 80 mph (129 km/h) | 04h 50m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $5.77 | $79.09 | $158.19 |
| Mid-grade | $6.07 | $83.16 | $166.33 |
| Premium | $6.24 | $85.59 | $171.18 |
| Diesel | $7.57 | $103.74 | $207.49 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in California · Apr 18, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.