How far is Doniphan, MO from St. Louis, MO?
The driving distance from Doniphan, MO to St. Louis, MO is about 179.1 miles (288.2 km), with a travel time of about 02h 57m by car.
- The straight-line flight distance is about 142.8 miles (229.8 km).
- For a round trip, plan for roughly 05h 54m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 57m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Madison County, Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Showers And Thunderstorms Likely
Driving Route Map
The map below follows the saved road route between Doniphan and St. Louis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Doniphan and St. Louis.
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1
Start on Plum Street
52 m · 10 sec · Plum Street
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2
Turn right onto Walnut Street
1.1 km · 1 min · Walnut Street
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3
Turn right
18.3 mi · 27 min
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4
Turn left
30 m · 2 sec
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5
Take the ramp slight right
890 ft · 24 sec
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6
Merge slight left
10.5 mi · 11 min
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7
Take the exit slight right toward US 60 West, US 67 North: Springfield
113.3 mi · 2 hr 10 min
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8
Keep slight right
1750 ft · 27 sec
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9
Take the exit straight toward I 55 North: Saint Louis
1735 ft · 49 sec
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10
Merge slight left
20.5 mi · 22 min
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11
Continue on Rosa Parks Highway
12.5 mi · 16 min · Rosa Parks Highway
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12
Take the exit slight right toward MO 30 East: Gravois Avenue
1001 ft · 24 sec
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13
Turn slight right onto Gravois Avenue
1044 ft · 27 sec · Gravois Avenue
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14
Continue on South Tucker Boulevard
1.3 mi · 3 min · South Tucker Boulevard
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15
Turn right onto Market Street
26 m · 2 sec · Market Street
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16
Arrive at your destination
0 m · 1 sec · Market Street
Car Route Details
A richer read on the saved driving route between Doniphan and St. Louis.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
US 60 West
Take the exit slight right toward US 60 West, US 67 North: Springfield
113 mi · 02h 10m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Chance Showers And Thunderstorms leaving Doniphan and Showers And Thunderstorms Likely near St. Louis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Doniphan to St. Louis?
The road trip is about 179.1 miles (288.2 km) and usually takes 02h 57m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Cobalt Village is a useful midpoint, sitting about 89.3 miles from Doniphan and 89.8 miles from St. Louis.
How much longer is the road route than the straight-line distance?
The direct path is about 142.8 miles (229.8 km), while the road route adds roughly 36.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 12:36 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $23.83 one way or $47.67 round trip. Estimated CO2 is about 56.2 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Doniphan and Showers And Thunderstorms Likely near St. Louis.
Stop Ideas Near Cobalt Village
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Cobalt Village.
Poplar Bluff
Carbondale station
Du Quoin
Kirkwood
Flight Path Map
This map shows the direct air route between Doniphan and St. Louis. Straight-line distance: 142.79 mi (229.8 km).
#1 Doniphan
City in Ripley County, Missouri, United States
| Population | 1,919 |
| Coordinates | 36.6208900, -90.8234600 |
| Altitude | 122 |
| Country | United States |
#2 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
End: Market Street (-90.197859, 38.627348)
Estimated Travel Time
Distance: 288 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 58m |
| 40 mph (64.37 km/h) | 04h 28m |
| 50 mph (80.47 km/h) | 03h 34m |
| 60 mph (96.56 km/h) | 02h 59m |
| 70 mph (112.65 km/h) | 02h 33m |
| 80 mph (129 km/h) | 02h 14m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $23.83 | $47.67 |
| Mid-grade | $4.25 | $26.88 | $53.76 |
| Premium | $4.65 | $29.41 | $58.83 |
| Diesel | $5.30 | $33.52 | $67.04 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 18, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.