How far is Chillicothe, MO from Chesterfield, MO?
The driving distance from Chillicothe, MO to Chesterfield, MO is about 216.1 miles (347.8 km), with a travel time of about 03h 30m by car.
- The straight-line flight distance is about 177.4 miles (285.5 km).
- For a round trip, plan for roughly 07h 01m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 30m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Village in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms Likely
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Chillicothe and Chesterfield.
Turn-by-Turn Driving Directions
Step-by-step road directions between Chillicothe and Chesterfield.
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1
Start on Locust Street
16 m · 4 sec · Locust Street
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2
Turn right onto West Calhoun Street
98 m · 18 sec · West Calhoun Street
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3
Turn left onto North Washington Street
1.6 mi · 4 min · North Washington Street
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4
Take the ramp left toward US 36 East, MO 110 East: Brookfield
975 ft · 13 sec
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5
Merge slight left onto Chicago-Kansas City Expressway
111.4 mi · 2 hr 9 min · Chicago-Kansas City Expressway
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6
Continue on V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
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7
Take the exit slight right toward Veterans Road
1167 ft · 30 sec
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8
Turn right onto Veterans Road
2.1 mi · 4 min · Veterans Road
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9
At the end of the road, turn left onto County Road 422
85 m · 7 sec · County Road 422
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10
Continue on Paris Gravel Road
2539 ft · 1 min · Paris Gravel Road
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11
Take the ramp right
37 m · 3 sec
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12
Merge slight left onto Avenue of the Saints
90.2 mi · 1 hr 47 min · Avenue of the Saints
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13
Take the exit slight right toward Boone's Crossing
1068 ft · 26 sec
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14
Turn right onto Boone's Crossing
549 ft · 21 sec · Boone's Crossing
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15
Turn left onto Chesterfield Airport Road
1.2 mi · 2 min · Chesterfield Airport Road
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16
Turn slight right onto Baxter Road
65 m · 8 sec
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17
Turn slight right onto Baxter Road
1397 ft · 34 sec · Baxter Road
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18
Turn left onto Old Chesterfield Road
891 ft · 40 sec · Old Chesterfield Road
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19
Turn right onto Santa Maria Drive
33 m · 5 sec · Santa Maria Drive
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20
Arrive at your destination
0 m · 1 sec · Santa Maria Drive
Car Route Details
A richer read on the saved driving route between Chillicothe and Chesterfield.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Chicago-Kansas City Expressway
Merge slight left onto Chicago-Kansas City Expressway
111 mi · 02h 09m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms Likely leaving Chillicothe and Showers And Thunderstorms near Chesterfield.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Chillicothe to Chesterfield?
The road trip is about 216.1 miles (347.8 km) and usually takes 03h 30m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Rensselaer is a useful midpoint, sitting about 107 miles from Chillicothe and 109.2 miles from Chesterfield.
How much longer is the road route than the straight-line distance?
The direct path is about 177.4 miles (285.5 km), while the road route adds roughly 38.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 9:58 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $28.77 one way or $57.55 round trip. Estimated CO2 is about 67.8 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms Likely around Chillicothe and Showers And Thunderstorms near Chesterfield.
Stop Ideas Near Rensselaer
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Rensselaer.
Quincy
La Plata
Fort Madison station
Hermann
Flight Path Map
This map shows the direct air route between Chillicothe and Chesterfield. Straight-line distance: 177.41 mi (285.51 km).
#1 Chillicothe
City in Missouri
| Population | 8,915 |
| Coordinates | 39.7952900, -93.5524400 |
| Altitude | 243 |
| Country | United States |
#2 Chesterfield
A city in St.
| Population | 47,570 |
| Coordinates | 38.6631100, -90.5770700 |
| Altitude | 144 |
| Country | United States |
End: Santa Maria Drive (-90.576914, 38.663102)
Estimated Travel Time
Distance: 348 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 12m |
| 40 mph (64.37 km/h) | 05h 24m |
| 50 mph (80.47 km/h) | 04h 19m |
| 60 mph (96.56 km/h) | 03h 36m |
| 70 mph (112.65 km/h) | 03h 05m |
| 80 mph (129 km/h) | 02h 41m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $28.77 | $57.55 |
| Mid-grade | $4.25 | $32.45 | $64.90 |
| Premium | $4.65 | $35.51 | $71.02 |
| Diesel | $5.30 | $40.47 | $80.94 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 05, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.