How far is Cape Girardeau, MO from Saint Ann, MO?
The driving distance from Cape Girardeau, MO to Saint Ann, MO is about 126.2 miles (203.1 km), with a travel time of about 02h 26m by car.
- The straight-line flight distance is about 108.9 miles (175.3 km).
- For a round trip, plan for roughly 04h 52m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 26m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Sainte Genevieve County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Saint Ann.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Saint Ann.
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1
Start on Broadway Street
2 mi · 4 min · Broadway Street
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2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
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3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
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4
Merge slight left
95.1 mi · 1 hr 42 min
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5
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
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6
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
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7
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
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8
Continue on I 270 West
1.2 km · 1 min
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9
Merge slight left
18.1 mi · 23 min
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10
Take the exit slight right toward I 70: Kansas City, Saint Louis, Saint Louis Lambert International Airport
1 mi · 1 min
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11
Keep slight right to continue on I 70 East: Saint Louis
2031 ft · 33 sec
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12
Merge slight left
1.6 km · 1 min
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13
Take the exit slight right toward MO 180: Saint Charles Rock Road
1485 ft · 32 sec
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14
Turn right onto Saint Charles Rock Road
1.1 km · 1 min · Saint Charles Rock Road
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15
Continue on Saint Charles Rock Road
1.2 mi · 2 min · Saint Charles Rock Road
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16
Turn right onto San Jose Lane
90 m · 13 sec · San Jose Lane
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17
Continue on San Jose Lane
38 m · 5 sec · San Jose Lane
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18
Arrive at your destination
0 m · 1 sec · San Jose Lane
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Saint Ann.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 North
Merge slight left
95.1 mi · 01h 42m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Sunny leaving Cape Girardeau and Sunny near Saint Ann.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Saint Ann?
The road trip is about 126.2 miles (203.1 km) and usually takes 02h 26m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Bloomsdale is a useful midpoint, sitting about 63.1 miles from Cape Girardeau and 63.1 miles from Saint Ann.
How much longer is the road route than the straight-line distance?
The direct path is about 108.9 miles (175.3 km), while the road route adds roughly 17.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 1:38 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $16.78 one way or $33.56 round trip. Estimated CO2 is about 39.5 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Cape Girardeau and Sunny near Saint Ann.
Stop Ideas Near Bloomsdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Bloomsdale.
Kirkwood
Gateway Transportation Center
Du Quoin
Carbondale station
Flight Path Map
This map shows the direct air route between Cape Girardeau and Saint Ann. Straight-line distance: 108.91 mi (175.28 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Saint Ann
City in Saint Louis County, Missouri, United States
| Population | 12,583 |
| Coordinates | 38.7272700, -90.3831700 |
| Altitude | 177 |
| Country | United States |
End: Saint Ann (-90.38317, 38.72727)
Estimated Travel Time
Distance: 203 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 04h 12m |
| 40 mph (64.37 km/h) | 03h 09m |
| 50 mph (80.47 km/h) | 02h 31m |
| 60 mph (96.56 km/h) | 02h 06m |
| 70 mph (112.65 km/h) | 01h 48m |
| 80 mph (129 km/h) | 01h 34m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $16.78 | $33.56 |
| Mid-grade | $4.25 | $18.93 | $37.85 |
| Premium | $4.65 | $20.71 | $41.42 |
| Diesel | $5.30 | $23.60 | $47.21 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.