How far is Cape Girardeau, MO from Odessa, MO?
The driving distance from Cape Girardeau, MO to Odessa, MO is about 314.3 miles (505.8 km), with a travel time of about 06h 00m by car.
- The straight-line flight distance is about 267.9 miles (431.1 km).
- For a round trip, plan for roughly 12h 00m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 00m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Warren County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny then Chance Showers And Thunderstorms
Slight Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Odessa.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Odessa.
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1
Start on Broadway Street
2 mi · 4 min · Broadway Street
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2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
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3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
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4
Merge slight left
95.1 mi · 1 hr 42 min
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5
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
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6
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
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7
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
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8
Continue on I 270 West
1.2 km · 1 min
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9
Merge slight left
11.5 mi · 14 min
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10
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
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11
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
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12
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
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13
Merge slight left onto Avenue of the Saints
25.4 mi · 31 min · Avenue of the Saints
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14
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
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15
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 1 hr 35 min · Dwight D Eisenhower Highway
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16
Continue on Sheriff Roger I. Wilson Memorial Highway
2 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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17
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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18
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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19
Continue on U.S. Submarine Veterans' Memorial Highway
54.4 mi · 58 min · U.S. Submarine Veterans' Memorial Highway
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20
Continue on Dwight D. Eisenhower Highway
31 mi · 33 min · Dwight D. Eisenhower Highway
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21
Take the exit slight right toward MO 131 South: Odessa
1100 ft · 29 sec
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22
Turn left onto North Johnson Drive
1 km · 2 min · North Johnson Drive
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23
Turn right onto East Mason Street
3060 ft · 1 min · East Mason Street
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24
Arrive at your destination
0 m · 1 sec · West Mason Street
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Odessa.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 55 North
Merge slight left
95.1 mi · 01h 42m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny then Chance Showers And Thunderstorms leaving Cape Girardeau and Slight Chance Showers And Thunderstorms near Odessa.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Odessa?
The road trip is about 314.3 miles (505.8 km) and usually takes 06h 00m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Truesdale is a useful midpoint, sitting about 157 miles from Cape Girardeau and 157.3 miles from Odessa.
How much longer is the road route than the straight-line distance?
The direct path is about 267.9 miles (431.1 km), while the road route adds roughly 46.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 5:00 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $41.82 one way or $83.64 round trip. Estimated CO2 is about 98.6 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny then Chance Showers And Thunderstorms around Cape Girardeau and Slight Chance Showers And Thunderstorms near Odessa.
Stop Ideas Near Truesdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Warrenton City Animal Control
Moscow Mills City Hall
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Truesdale.
Hermann
Washington
Kirkwood
Gateway Transportation Center
Flight Path Map
This map shows the direct air route between Cape Girardeau and Odessa. Straight-line distance: 267.84 mi (431.05 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Odessa
City in Missouri
| Population | 5,295 |
| Coordinates | 38.9991700, -93.9535600 |
| Altitude | 285 |
| Country | United States |
End: Odessa (-93.95356, 38.99917)
Estimated Travel Time
Distance: 506 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 28m |
| 40 mph (64.37 km/h) | 07h 51m |
| 50 mph (80.47 km/h) | 06h 17m |
| 60 mph (96.56 km/h) | 05h 14m |
| 70 mph (112.65 km/h) | 04h 29m |
| 80 mph (129 km/h) | 03h 55m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $41.82 | $83.64 |
| Mid-grade | $4.25 | $47.17 | $94.33 |
| Premium | $4.65 | $51.61 | $103.23 |
| Diesel | $5.30 | $58.82 | $117.64 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 17, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.