How far is Cape Girardeau, MO from Kirksville, MO?
The driving distance from Cape Girardeau, MO to Kirksville, MO is about 309 miles (497.3 km), with a travel time of about 06h 03m by car.
- The straight-line flight distance is about 259 miles (416.9 km).
- For a round trip, plan for roughly 12h 07m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 03m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Lincoln County, Montana, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Clear
Sunny
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Kirksville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Kirksville.
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1
Start on Broadway Street
2 mi · 4 min · Broadway Street
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2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
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3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
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4
Merge slight left
95.1 mi · 1 hr 42 min
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5
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
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6
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
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7
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
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8
Continue on I 270 West
1.2 km · 1 min
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9
Merge slight left
11.5 mi · 14 min
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10
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
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11
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
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12
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
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13
Merge slight left onto Avenue of the Saints
98.8 mi · 1 hr 58 min · Avenue of the Saints
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14
Take the exit slight left
76 m · 15 sec
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15
Turn left onto Paris Gravel Road
2645 ft · 1 min · Paris Gravel Road
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16
Keep slight right to continue on County Road 422
85 m · 9 sec · County Road 422
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17
Turn right onto Veterans Road
2.2 mi · 4 min · Veterans Road
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18
Take the ramp left toward US 36 West, MO 110 West: Monroe City
1226 ft · 16 sec
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19
Merge slight left onto V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
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20
Continue on Chicago-Kansas City Expressway
52.9 mi · 1 hr 1 min · Chicago-Kansas City Expressway
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21
Take the exit slight right toward US 63: Macon, Kirksville
1054 ft · 29 sec
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22
Turn right onto North Missouri Street
28.5 mi · 32 min · North Missouri Street
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23
Take the exit slight right toward US 63 Business: Kirksville
1 km · 1 min
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24
Continue on South Baltimore Street
1.6 mi · 2 min · South Baltimore Street
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25
Turn slight left onto Kirksville, Truman State University
76 m · 11 sec
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26
Continue on South Franklin Street
2 mi · 5 min · South Franklin Street
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27
Arrive at your destination
0 m · 1 sec · North Franklin Street
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Kirksville.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Avenue of the Saints
Merge slight left onto Avenue of the Saints
98.8 mi · 01h 58m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Mostly Clear leaving Cape Girardeau and Sunny near Kirksville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Kirksville?
The road trip is about 309 miles (497.3 km) and usually takes 06h 03m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Troy is a useful midpoint, sitting about 154.5 miles from Cape Girardeau and 154.5 miles from Kirksville.
How much longer is the road route than the straight-line distance?
The direct path is about 259 miles (416.9 km), while the road route adds roughly 50 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $41.10 one way or $82.21 round trip. Estimated CO2 is about 96.9 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Clear around Cape Girardeau and Sunny near Kirksville.
Stop Ideas Near Troy
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Troy.
Washington
Hermann
Kirkwood
Alton
Flight Path Map
This map shows the direct air route between Cape Girardeau and Kirksville. Straight-line distance: 259.04 mi (416.88 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Kirksville
City in Adair County, Missouri, United States
| Population | 17,653 |
| Coordinates | 40.1947500, -92.5832500 |
| Altitude | 299 |
| Country | United States |
End: Kirksville (-92.58325, 40.19475)
Estimated Travel Time
Distance: 497 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 17m |
| 40 mph (64.37 km/h) | 07h 43m |
| 50 mph (80.47 km/h) | 06h 10m |
| 60 mph (96.56 km/h) | 05h 08m |
| 70 mph (112.65 km/h) | 04h 24m |
| 80 mph (129 km/h) | 03h 51m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $41.10 | $82.21 |
| Mid-grade | $4.25 | $46.36 | $92.72 |
| Premium | $4.65 | $50.73 | $101.46 |
| Diesel | $5.30 | $57.81 | $115.63 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Jun 03, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.