How far is Cape Coral, FL from Key Largo, FL?
The driving distance from Cape Coral, FL to Key Largo, FL is about 199.8 miles (321.6 km), with a travel time of about 04h 03m by car.
- The straight-line flight distance is about 138.3 miles (222.6 km).
- For a round trip, plan for roughly 08h 07m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 03m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
A city in Broward County, Florida.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Slight Chance Rain Showers
Driving Route Map
The map below follows the saved road route between Cape Coral and Key Largo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Coral and Key Largo.
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1
Start on the route
29 m · 7 sec
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2
Turn right onto Cape Coral Parkway East
38 m · 9 sec · Cape Coral Parkway East
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3
Continue on Cape Coral Parkway East
1.1 mi · 2 min · Cape Coral Parkway East
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4
Continue on Cape Coral Bridge Road
1.5 km · 2 min · Cape Coral Bridge Road
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5
Continue on College Parkway
2.9 mi · 5 min · College Parkway
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6
Turn right onto South Cleveland Avenue
1.1 km · 1 min · South Cleveland Avenue
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7
Turn left onto Daniels Parkway
4.6 mi · 8 min · Daniels Parkway
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8
Take the ramp slight right toward I 75 South: Naples
2673 ft · 1 min
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9
Merge slight left
106.5 mi · 1 hr 54 min
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10
Take the exit slight right toward US 27: Miami, South Bay
1118 ft · 21 sec
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11
Keep slight right to continue on US 27 South: Miami
2407 ft · 59 sec
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12
Merge slight left
9.2 mi · 11 min
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13
Keep slight right
8.6 mi · 11 min
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14
Take the exit right toward Florida's Turnpike South: Homestead, Key West
1324 ft · 32 sec
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15
Merge slight left onto Homestead Extension of Florida's Turnpike
34.5 mi · 41 min · Homestead Extension of Florida's Turnpike
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16
Keep slight left
2930 ft · 1 min
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17
Merge slight left onto Dixie Highway
19.2 mi · 27 min · Dixie Highway
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18
Continue on Overseas Highway
9.3 mi · 16 min · Overseas Highway
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19
Continue on Overseas Highway
138 m · 28 sec · Overseas Highway
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20
Turn right onto Harbor Drive
94 m · 14 sec · Harbor Drive
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21
Arrive at your destination
0 m · 1 sec · Harbor Drive
Car Route Details
A richer read on the saved driving route between Cape Coral and Key Largo.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 75 South
Merge slight left
107 mi · 01h 54m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Cape Coral and Slight Chance Rain Showers near Key Largo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Coral to Key Largo?
The road trip is about 199.8 miles (321.6 km) and usually takes 04h 03m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Weston is a useful midpoint, sitting about 100 miles from Cape Coral and 99.9 miles from Key Largo.
How much longer is the road route than the straight-line distance?
The direct path is about 138.3 miles (222.6 km), while the road route adds roughly 61.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 8:52 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $29.24 one way or $58.49 round trip. Estimated CO2 is about 62.7 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Cape Coral and Slight Chance Rain Showers near Key Largo.
Stop Ideas Near Weston
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Weston.
Fort Lauderdale
Hollywood
Miami Intermodal Center
Deerfield Beach
Flight Path Map
This map shows the direct air route between Cape Coral and Key Largo. Straight-line distance: 138.32 mi (222.61 km).
#1 Cape Coral
The second most populous city in Lee County, Florida.
| Population | 200,972 |
| Coordinates | 26.5628500, -81.9495300 |
| Altitude | 1 |
| Country | United States |
#2 Key Largo
Census designated place in Florida, United States
| Population | 10,433 |
| Coordinates | 25.0865200, -80.4472800 |
| Altitude | 2 |
| Country | United States |
End: Key Largo (-80.44728, 25.08652)
Estimated Travel Time
Distance: 322 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 39m |
| 40 mph (64.37 km/h) | 04h 59m |
| 50 mph (80.47 km/h) | 03h 59m |
| 60 mph (96.56 km/h) | 03h 19m |
| 70 mph (112.65 km/h) | 02h 51m |
| 80 mph (129 km/h) | 02h 29m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $29.24 | $58.49 |
| Mid-grade | $4.60 | $32.40 | $64.80 |
| Premium | $4.90 | $34.52 | $69.03 |
| Diesel | $4.35 | $30.67 | $61.33 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 07, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.