How far is Cameron, MO from St. Louis, MO?
The driving distance from Cameron, MO to St. Louis, MO is about 270.6 miles (435.5 km), with a travel time of about 04h 16m by car.
- The straight-line flight distance is about 229.8 miles (369.8 km).
- For a round trip, plan for roughly 08h 32m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 16m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Monroe County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Cameron and St. Louis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cameron and St. Louis.
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1
Start on West 2nd Street
12 m · 4 sec · West 2nd Street
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2
Turn right onto North Pine Street
758 ft · 35 sec · North Pine Street
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3
Turn right onto West 4th Street
1489 ft · 48 sec · West 4th Street
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4
Turn left onto North Walnut Street
1.2 km · 2 min · North Walnut Street
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5
Take the ramp slight right toward US 36 East: Hamilton
1165 ft · 18 sec
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6
Merge slight left
149.3 mi · 2 hr 53 min
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7
Continue on V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
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8
Take the exit slight right toward Veterans Road
1167 ft · 30 sec
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9
Turn right onto Veterans Road
2.1 mi · 4 min · Veterans Road
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10
At the end of the road, turn left onto County Road 422
85 m · 7 sec · County Road 422
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11
Continue on Paris Gravel Road
2539 ft · 1 min · Paris Gravel Road
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12
Take the ramp right
37 m · 3 sec
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13
Merge slight left onto Avenue of the Saints
101.3 mi · 2 hr 1 min · Avenue of the Saints
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14
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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15
Continue on Jack Buck Memorial Highway
5.8 mi · 7 min · Jack Buck Memorial Highway
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16
Take the exit slight right toward 14th Street
1115 ft · 34 sec
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17
Turn left onto South 14th Street
1715 ft · 42 sec · South 14th Street
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18
Turn right onto Market Street
956 ft · 27 sec · Market Street
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19
Arrive at your destination
0 m · 1 sec · Market Street
Car Route Details
A richer read on the saved driving route between Cameron and St. Louis.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
US 36 East
Merge slight left
149 mi · 02h 53m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Cameron and Sunny near St. Louis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cameron to St. Louis?
The road trip is about 270.6 miles (435.5 km) and usually takes 04h 16m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Monroe City is a useful midpoint, sitting about 136.3 miles from Cameron and 134.4 miles from St. Louis.
How much longer is the road route than the straight-line distance?
The direct path is about 229.8 miles (369.8 km), while the road route adds roughly 40.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:28 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $36.01 one way or $72.03 round trip. Estimated CO2 is about 84.9 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Cameron and Sunny near St. Louis.
Stop Ideas Near Monroe City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Monroe City.
Quincy
La Plata
Hermann
Fort Madison station
Flight Path Map
This map shows the direct air route between Cameron and St. Louis. Straight-line distance: 229.76 mi (369.76 km).
#1 Cameron
City in Missouri, USA
| Population | 8,136 |
| Coordinates | 39.7402800, -94.2410600 |
| Altitude | 315 |
| Country | United States |
#2 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
End: Market Street (-90.197859, 38.627348)
Estimated Travel Time
Distance: 436 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 01m |
| 40 mph (64.37 km/h) | 06h 45m |
| 50 mph (80.47 km/h) | 05h 24m |
| 60 mph (96.56 km/h) | 04h 30m |
| 70 mph (112.65 km/h) | 03h 51m |
| 80 mph (129 km/h) | 03h 22m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $36.01 | $72.03 |
| Mid-grade | $4.25 | $40.62 | $81.23 |
| Premium | $4.65 | $44.45 | $88.89 |
| Diesel | $5.30 | $50.65 | $101.31 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 13, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.