How far is Biloxi, MS from Holly Springs, MS?
The driving distance from Biloxi, MS to Holly Springs, MS is about 349.9 miles (563.1 km), with a travel time of about 06h 58m by car.
- The straight-line flight distance is about 303.9 miles (489 km).
- For a round trip, plan for roughly 13h 56m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 58m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Madison County, Florida, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Slight Chance Rain Showers then Mostly Cloudy
Slight Chance Rain Showers then Mostly Sunny
Driving Route Map
The map below follows the saved road route between Biloxi and Holly Springs.
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi and Holly Springs.
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1
Start on Howard Avenue
28 m · 6 sec · Howard Avenue
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2
Turn right onto Main Street
2572 ft · 1 min · Main Street
-
3
Turn left onto Division Street
2603 ft · 2 min · Division Street
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4
Take the ramp right toward Bohn Street
42 m · 3 sec · Bohn Street
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5
Turn straight
1522 ft · 37 sec
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6
Merge slight left
3.1 mi · 4 min
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7
Continue straight
20.7 mi · 24 min
-
8
Keep slight right to continue on US 49 North: Hattiesburg, Jackson
2209 ft · 47 sec
-
9
Merge slight left
39.8 mi · 47 min
-
10
Continue straight
2.4 mi · 3 min
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11
Turn straight
10.3 mi · 16 min
-
12
Continue straight
5.4 mi · 7 min
-
13
Continue straight
5.3 mi · 6 min
-
14
Continue straight
1077 ft · 14 sec
-
15
Continue straight
4.2 mi · 5 min
-
16
Continue straight
65.7 mi · 1 hr 20 min
-
17
Take the exit slight right
862 ft · 21 sec
-
18
Keep slight left to continue on Jackson
1.1 km · 1 min
-
19
Keep slight right
1.5 km · 1 min
-
20
Merge slight left
116.5 mi · 2 hr 7 min
-
21
Take the exit slight right toward MS 7 North: Coffeeville
36.4 mi · 42 min
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22
Enter the roundabout and take exit 2 toward MS 7 North: Oxford
52 m · 2 sec
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23
Exit the roundabout onto MS 7 North: Oxford
36.4 mi · 50 min
-
24
Turn right onto West Van Dorn Avenue
688 ft · 19 sec · West Van Dorn Avenue
-
25
Turn left onto North Memphis Street
9 m · 1 sec · North Memphis Street
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26
Arrive at your destination
0 m · 1 sec · North Memphis Street
Car Route Details
A richer read on the saved driving route between Biloxi and Holly Springs.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Jackson
Merge slight left
117 mi · 02h 07m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Slight Chance Rain Showers then Mostly Cloudy leaving Biloxi and Slight Chance Rain Showers then Mostly Sunny near Holly Springs.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Biloxi to Holly Springs?
The road trip is about 349.9 miles (563.1 km) and usually takes 06h 58m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Madison is a useful midpoint, sitting about 175.2 miles from Biloxi and 174.7 miles from Holly Springs.
How much longer is the road route than the straight-line distance?
The direct path is about 303.9 miles (489 km), while the road route adds roughly 46 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $46.77 one way or $93.54 round trip. Estimated CO2 is about 109.8 kg one way.
What should you check before leaving?
Before you leave, expect Slight Chance Rain Showers then Mostly Cloudy around Biloxi and Slight Chance Rain Showers then Mostly Sunny near Holly Springs.
Stop Ideas Near Madison
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Madison.
Union Station
Yazoo City
Hazlehurst station
Vicksburg, MS
Flight Path Map
This map shows the direct air route between Biloxi and Holly Springs. Straight-line distance: 303.82 mi (488.95 km).
#1 Biloxi
The most populous city in Harrison County, Mississippi.
| Population | 46,127 |
| Coordinates | 30.3960300, -88.8853100 |
| Altitude | 6 |
| Country | United States |
#2 Holly Springs
City in and county seat of Marshall County, Mississippi, United States
| Population | 7,610 |
| Coordinates | 34.7676000, -89.4486900 |
| Altitude | 183 |
| Country | United States |
End: Holly Springs (-89.44869, 34.7676)
Estimated Travel Time
Distance: 563 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 39m |
| 40 mph (64.37 km/h) | 08h 44m |
| 50 mph (80.47 km/h) | 06h 59m |
| 60 mph (96.56 km/h) | 05h 49m |
| 70 mph (112.65 km/h) | 04h 59m |
| 80 mph (129 km/h) | 04h 21m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $46.77 | $93.54 |
| Mid-grade | $4.26 | $52.60 | $105.20 |
| Premium | $4.63 | $57.12 | $114.24 |
| Diesel | $5.42 | $66.88 | $133.75 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.