How far is Holly Springs, MS from Biloxi, MS?
The driving distance from Holly Springs, MS to Biloxi, MS is about 368.2 miles (592.6 km), with a travel time of about 05h 45m by car.
- The straight-line flight distance is about 303.9 miles (489 km).
- For a round trip, plan for roughly 11h 31m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 45m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Madison County, Florida, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Slight Chance Rain Showers then Mostly Sunny
Slight Chance Rain Showers then Mostly Cloudy
Driving Route Map
The map below follows the saved road route between Holly Springs and Biloxi.
Turn-by-Turn Driving Directions
Step-by-step road directions between Holly Springs and Biloxi.
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1
Start on North Memphis Street
9 m · 5 sec · North Memphis Street
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2
Turn right onto West Van Dorn Avenue
688 ft · 17 sec · West Van Dorn Avenue
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3
Turn left onto South Craft Street
36.3 mi · 50 min · South Craft Street
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4
Enter the roundabout and take exit 1 toward MS 7 South: Water Valley
38 m · 2 sec
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5
Exit the roundabout onto MS 7 South: Water Valley
36.4 mi · 41 min
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6
Take the exit slight left
101 mi · 1 hr 48 min
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7
Continue straight
15.6 mi · 19 min
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8
Take the exit slight right toward I 20 East, US 49 South: Meridian, Hattiesburg
1.5 km · 1 min
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9
Keep slight right to continue on Richland, Hattiesburg
1.2 km · 2 min
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10
Merge slight left onto Highway 49 South
80.3 mi · 1 hr 37 min · Highway 49 South
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11
Continue straight
2294 ft · 36 sec
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12
Continue straight
1.1 mi · 2 min
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13
Take the exit slight right toward I 59 South: New Orleans, Gulf Coast
1914 ft · 36 sec
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14
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
7.7 mi · 8 min · Lance Corporal Roy M Wheat Memorial Highway
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15
Take the exit slight right toward US 98 East: Lucedale, Mobile
3.2 mi · 4 min
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16
Take the exit slight right toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
1558 ft · 44 sec
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17
Keep slight left to continue on Multi Purpose Center, Hattiesburg
833 ft · 28 sec
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18
Turn right
41.9 mi · 49 min
-
19
Take the exit slight right toward MS 67 South: D'Iberville, Biloxi
1.2 km · 1 min
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20
Continue on Biloxi-D'Iberville Scenic Expressway
20.5 mi · 24 min · Biloxi-D'Iberville Scenic Expressway
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21
Continue straight
3.2 mi · 4 min
-
22
Take the exit slight right toward Division Street
1852 ft · 47 sec
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23
Turn left onto Division Street
3090 ft · 2 min · Division Street
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24
Turn right onto Main Street
2572 ft · 1 min · Main Street
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25
Turn left onto Howard Avenue
28 m · 3 sec · Howard Avenue
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26
Arrive at your destination
0 m · 1 sec · Howard Avenue
Car Route Details
A richer read on the saved driving route between Holly Springs and Biloxi.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
MS 7 South
Take the exit slight left
101 mi · 01h 48m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Slight Chance Rain Showers then Mostly Sunny leaving Holly Springs and Slight Chance Rain Showers then Mostly Cloudy near Biloxi.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Holly Springs to Biloxi?
The road trip is about 368.2 miles (592.6 km) and usually takes 05h 45m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Madison is a useful midpoint, sitting about 176.4 miles from Holly Springs and 191.8 miles from Biloxi.
How much longer is the road route than the straight-line distance?
The direct path is about 303.9 miles (489 km), while the road route adds roughly 64.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 5:28 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $49.19 one way or $98.39 round trip. Estimated CO2 is about 115.4 kg one way.
What should you check before leaving?
Before you leave, expect Slight Chance Rain Showers then Mostly Sunny around Holly Springs and Slight Chance Rain Showers then Mostly Cloudy near Biloxi.
Stop Ideas Near Madison
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Madison.
Union Station
Yazoo City
Hazlehurst station
Vicksburg, MS
Flight Path Map
This map shows the direct air route between Holly Springs and Biloxi. Straight-line distance: 303.82 mi (488.95 km).
#1 Holly Springs
City in and county seat of Marshall County, Mississippi, United States
| Population | 7,610 |
| Coordinates | 34.7676000, -89.4486900 |
| Altitude | 183 |
| Country | United States |
#2 Biloxi
The most populous city in Harrison County, Mississippi.
| Population | 46,127 |
| Coordinates | 30.3960300, -88.8853100 |
| Altitude | 6 |
| Country | United States |
End: Howard Avenue (-88.885301, 30.396075)
Estimated Travel Time
Distance: 593 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 12h 16m |
| 40 mph (64.37 km/h) | 09h 12m |
| 50 mph (80.47 km/h) | 07h 21m |
| 60 mph (96.56 km/h) | 06h 08m |
| 70 mph (112.65 km/h) | 05h 15m |
| 80 mph (129 km/h) | 04h 35m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $49.19 | $98.39 |
| Mid-grade | $4.26 | $55.32 | $110.65 |
| Premium | $4.63 | $60.08 | $120.16 |
| Diesel | $5.42 | $70.34 | $140.68 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.