How far is Biloxi, MS from Clarksdale, MS?
The driving distance from Biloxi, MS to Clarksdale, MS is about 318.9 miles (513.2 km), with a travel time of about 06h 45m by car.
- The straight-line flight distance is about 280.7 miles (451.7 km).
- For a round trip, plan for roughly 13h 31m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 45m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Rankin County, Mississippi
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Biloxi and Clarksdale.
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi and Clarksdale.
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1
Start on Howard Avenue
28 m · 6 sec · Howard Avenue
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2
Turn right onto Main Street
2572 ft · 1 min · Main Street
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3
Turn left onto Division Street
2603 ft · 2 min · Division Street
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4
Take the ramp right toward Bohn Street
42 m · 3 sec · Bohn Street
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5
Turn straight
1522 ft · 37 sec
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6
Merge slight left
3.1 mi · 4 min
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7
Continue straight
20.7 mi · 24 min
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8
Keep slight right to continue on US 49 North: Hattiesburg, Jackson
2209 ft · 47 sec
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9
Merge slight left
39.8 mi · 47 min
-
10
Continue straight
2.4 mi · 3 min
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11
Turn straight
10.3 mi · 16 min
-
12
Continue straight
5.4 mi · 7 min
-
13
Continue straight
5.3 mi · 6 min
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14
Continue straight
1077 ft · 14 sec
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15
Continue straight
4.2 mi · 5 min
-
16
Continue straight
65.7 mi · 1 hr 20 min
-
17
Take the exit slight right
862 ft · 21 sec
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18
Keep slight left to continue on Jackson
1.1 km · 1 min
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19
Keep slight left
1 mi · 1 min
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20
Merge slight right
1.6 mi · 2 min
-
21
Keep slight right to continue on I 20 West, US 49 North: Vicksburg, Yazoo City
2.7 mi · 3 min
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22
Take the exit slight right toward I 220 North, I 49 North: North Jackson, Yazoo City
5.2 mi · 6 min
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23
Take the exit slight right toward US 49 North: Yazoo City
1360 ft · 33 sec
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24
Merge slight left onto Medgar Evers Boulevard
39.5 mi · 49 min · Medgar Evers Boulevard
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25
Take the exit slight right toward US 49W North, MS 3 South: Indianola, Vicksburg
46.7 mi · 57 min
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26
Turn left
1.2 km · 1 min
-
27
Turn right onto North Sunflower Avenue
13.5 mi · 24 min · North Sunflower Avenue
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28
Turn left
1.1 mi · 2 min
-
29
Turn right onto South Highway 61
43.9 mi · 55 min · South Highway 61
-
30
Turn left
2.1 mi · 4 min
-
31
Turn left onto Madison Avenue
2358 ft · 1 min · Madison Avenue
-
32
Turn right onto 4th Street
1821 ft · 55 sec · 4th Street
-
33
Turn left onto Issaquena Avenue
133 m · 21 sec · Issaquena Avenue
-
34
Turn right onto Edwards Alley
48 m · 12 sec · Edwards Alley
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35
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Biloxi and Clarksdale.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
US 49 North
Continue straight
65.7 mi · 01h 20m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Biloxi and Mostly Sunny near Clarksdale.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Biloxi to Clarksdale?
The road trip is about 318.9 miles (513.2 km) and usually takes 06h 45m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Pearl is a useful midpoint, sitting about 159.7 miles from Biloxi and 159.2 miles from Clarksdale.
How much longer is the road route than the straight-line distance?
The direct path is about 280.7 miles (451.7 km), while the road route adds roughly 38.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $42.60 one way or $85.21 round trip. Estimated CO2 is about 100 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Biloxi and Mostly Sunny near Clarksdale.
Stop Ideas Near Pearl
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Pearl.
Union Station
Hazlehurst station
Yazoo City
Vicksburg, MS
Flight Path Map
This map shows the direct air route between Biloxi and Clarksdale. Straight-line distance: 280.65 mi (451.67 km).
#1 Biloxi
The most populous city in Harrison County, Mississippi.
| Population | 46,127 |
| Coordinates | 30.3960300, -88.8853100 |
| Altitude | 6 |
| Country | United States |
#2 Clarksdale
City in Coahoma County, Mississippi, United States of America
| Population | 14,470 |
| Coordinates | 34.2001100, -90.5709300 |
| Altitude | 53 |
| Country | United States |
End: Clarksdale (-90.57093, 34.20011)
Estimated Travel Time
Distance: 513 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 37m |
| 40 mph (64.37 km/h) | 07h 58m |
| 50 mph (80.47 km/h) | 06h 22m |
| 60 mph (96.56 km/h) | 05h 18m |
| 70 mph (112.65 km/h) | 04h 33m |
| 80 mph (129 km/h) | 03h 58m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $42.60 | $85.21 |
| Mid-grade | $4.26 | $47.91 | $95.83 |
| Premium | $4.63 | $52.03 | $104.06 |
| Diesel | $5.42 | $60.92 | $121.84 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.