How far is Clarksdale, MS from Biloxi, MS?
The driving distance from Clarksdale, MS to Biloxi, MS is about 318.4 miles (512.4 km), with a travel time of about 05h 20m by car.
- The straight-line flight distance is about 280.7 miles (451.7 km).
- For a round trip, plan for roughly 10h 40m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 20m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Rankin County, Mississippi
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny
Partly Sunny
Driving Route Map
The map below follows the saved road route between Clarksdale and Biloxi.
Turn-by-Turn Driving Directions
Step-by-step road directions between Clarksdale and Biloxi.
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1
Start on the route
48 m · 17 sec
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2
Turn left onto Issaquena Avenue
133 m · 21 sec · Issaquena Avenue
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3
Turn right onto 4th Street
1821 ft · 56 sec · 4th Street
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4
At the end of the road, turn left onto Riverside Avenue
60 m · 5 sec · Riverside Avenue
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5
Continue on Madison Avenue
2160 ft · 1 min · Madison Avenue
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6
Turn right onto South State Street
2.1 mi · 4 min · South State Street
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7
Turn right
43.9 mi · 55 min
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8
Turn left onto East Peeler Avenue
1.1 mi · 2 min · East Peeler Avenue
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9
Turn right
13.5 mi · 24 min
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10
Turn left
1.1 km · 1 min
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11
Turn right onto North Martin Luther King Drive
46.2 mi · 56 min · North Martin Luther King Drive
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12
Keep slight right to continue on US 49 South: Jackson
2791 ft · 53 sec
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13
Merge slight right onto Jerry Clower Boulevard
38.8 mi · 48 min · Jerry Clower Boulevard
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14
Take the exit slight right
4.9 mi · 6 min
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15
Keep slight left
3.8 mi · 5 min
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16
Merge slight right
1.1 mi · 1 min
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17
Keep slight right to continue on Meridian, Hattiesburg
106 m · 5 sec
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18
Take the exit slight right toward Hattiesburg
2977 ft · 42 sec
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19
Keep slight right to continue on Richland, Hattiesburg
1.2 km · 2 min
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20
Merge slight left onto Highway 49 South
80.3 mi · 1 hr 37 min · Highway 49 South
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21
Continue straight
2294 ft · 36 sec
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22
Continue straight
1.1 mi · 2 min
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23
Take the exit slight right toward I 59 South: New Orleans, Gulf Coast
1914 ft · 36 sec
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24
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
7.7 mi · 8 min · Lance Corporal Roy M Wheat Memorial Highway
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25
Take the exit slight right toward US 98 East: Lucedale, Mobile
3.2 mi · 4 min
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26
Take the exit slight right toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
1558 ft · 44 sec
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27
Keep slight left to continue on Multi Purpose Center, Hattiesburg
833 ft · 28 sec
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28
Turn right
41.9 mi · 49 min
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29
Take the exit slight right toward MS 67 South: D'Iberville, Biloxi
1.2 km · 1 min
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30
Continue on Biloxi-D'Iberville Scenic Expressway
20.5 mi · 24 min · Biloxi-D'Iberville Scenic Expressway
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31
Continue straight
3.2 mi · 4 min
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32
Take the exit slight right toward Division Street
1852 ft · 47 sec
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33
Turn left onto Division Street
3090 ft · 2 min · Division Street
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34
Turn right onto Main Street
2572 ft · 1 min · Main Street
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35
Turn left onto Howard Avenue
28 m · 3 sec · Howard Avenue
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36
Arrive at your destination
0 m · 1 sec · Howard Avenue
Car Route Details
A richer read on the saved driving route between Clarksdale and Biloxi.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Highway 49 South
Merge slight left onto Highway 49 South
80.3 mi · 01h 37m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Sunny leaving Clarksdale and Partly Sunny near Biloxi.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Clarksdale to Biloxi?
The road trip is about 318.4 miles (512.4 km) and usually takes 05h 20m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Richland is a useful midpoint, sitting about 160.3 miles from Clarksdale and 158.1 miles from Biloxi.
How much longer is the road route than the straight-line distance?
The direct path is about 280.7 miles (451.7 km), while the road route adds roughly 37.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:20 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $42.57 one way or $85.13 round trip. Estimated CO2 is about 99.9 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny around Clarksdale and Partly Sunny near Biloxi.
Stop Ideas Near Richland
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Richland.
Union Station
Hazlehurst station
Vicksburg, MS
Yazoo City
Flight Path Map
This map shows the direct air route between Clarksdale and Biloxi. Straight-line distance: 280.65 mi (451.67 km).
#1 Clarksdale
City in Coahoma County, Mississippi, United States of America
| Population | 14,470 |
| Coordinates | 34.2001100, -90.5709300 |
| Altitude | 53 |
| Country | United States |
#2 Biloxi
The most populous city in Harrison County, Mississippi.
| Population | 46,127 |
| Coordinates | 30.3960300, -88.8853100 |
| Altitude | 6 |
| Country | United States |
End: Howard Avenue (-88.885298, 30.396088)
Estimated Travel Time
Distance: 512 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 36m |
| 40 mph (64.37 km/h) | 07h 57m |
| 50 mph (80.47 km/h) | 06h 22m |
| 60 mph (96.56 km/h) | 05h 18m |
| 70 mph (112.65 km/h) | 04h 32m |
| 80 mph (129 km/h) | 03h 58m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $42.57 | $85.13 |
| Mid-grade | $4.26 | $47.87 | $95.74 |
| Premium | $4.63 | $51.99 | $103.97 |
| Diesel | $5.42 | $60.86 | $121.73 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.