How far is Tupelo, MS from De Lisle, MS?
The driving distance from Tupelo, MS to De Lisle, MS is about 309.8 miles (498.5 km), with a travel time of about 06h 02m by car.
- The straight-line flight distance is about 270 miles (434.5 km).
- For a round trip, plan for roughly 12h 05m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CST.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 02m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Clarke County, Mississippi, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Driving Route Map
The map below follows the saved road route between Tupelo and De Lisle.
Turn-by-Turn Driving Directions
Step-by-step road directions between Tupelo and De Lisle.
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1
Start on North Spring Street
21 m · 5 sec · North Spring Street
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2
Turn right onto Court Street
97 m · 16 sec · Court Street
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3
Turn right onto North Front Street
87 m · 15 sec · North Front Street
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4
Turn left onto East Main Street
2407 ft · 1 min · East Main Street
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5
Take the ramp straight
2248 ft · 56 sec
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6
Merge slight left onto Martin Luther King Drive
1.6 km · 1 min · Martin Luther King Drive
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7
Continue on Martin Luther King, Junior Drive
2.3 mi · 3 min · Martin Luther King, Junior Drive
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8
Continue on Martin Luther King Drive
7.7 mi · 9 min · Martin Luther King Drive
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9
Continue straight
1.4 mi · 2 min
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10
Continue straight
2.2 mi · 2 min
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11
Continue straight
1.5 mi · 2 min
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12
Continue straight
1.1 km · 49 sec
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13
Continue straight
1.4 mi · 2 min
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14
Continue on US Highway 45 Alternate
54.7 mi · 1 hr 6 min · US Highway 45 Alternate
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15
Continue on US Highway 45 Aiternate
60.6 mi · 1 hr 9 min · US Highway 45 Aiternate
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16
Keep slight right
3.9 mi · 4 min
-
17
Take the exit slight right toward I 59 South, I 20 West: Meridian
2689 ft · 1 min
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18
Merge slight left
6.3 mi · 8 min
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19
Continue straight
1.8 mi · 2 min
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20
Keep slight left to continue on I 59 South: Laurel, New Orleans
88.7 mi · 1 hr 36 min
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21
Take the exit slight right toward US 98 East: Lucedale, Mobile
3.2 mi · 4 min
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22
Take the exit slight right toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
1558 ft · 44 sec
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23
Keep slight left to continue on Multi Purpose Center, Hattiesburg
833 ft · 28 sec
-
24
Turn right
57.6 mi · 1 hr 9 min
-
25
Take the exit slight right toward I 10 West: New Orleans
2398 ft · 58 sec
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26
Merge slight left
8.9 mi · 10 min
-
27
Take the exit slight right toward Menge Avenue
1510 ft · 37 sec
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28
Keep slight left
39 m · 5 sec
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29
Turn left onto Firetower Road
68 m · 5 sec · Firetower Road
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30
Continue on Menge Avenue
1.5 mi · 3 min · Menge Avenue
-
31
Turn right onto Cuevas-Delisle Road
1.6 mi · 4 min · Cuevas-Delisle Road
-
32
Turn left onto Ball Park Road
21 m · 3 sec · Ball Park Road
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33
Arrive at your destination
0 m · 1 sec · Ball Park Road
Car Route Details
A richer read on the saved driving route between Tupelo and De Lisle.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 59 South
Keep slight left to continue on I 59 South: Laurel, New Orleans
88.7 mi · 01h 36m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Tupelo and Partly Sunny near De Lisle.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Tupelo to De Lisle?
The road trip is about 309.8 miles (498.5 km) and usually takes 06h 02m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Enterprise is a useful midpoint, sitting about 155.1 miles from Tupelo and 154.7 miles from De Lisle.
How much longer is the road route than the straight-line distance?
The direct path is about 270 miles (434.5 km), while the road route adds roughly 39.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CST. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $40.78 one way or $81.56 round trip. Estimated CO2 is about 97.1 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Tupelo and Partly Sunny near De Lisle.
Stop Ideas Near Enterprise
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Enterprise.
Union Station
Laurel station
Hattiesburg, MS
Hattiesburg station
Flight Path Map
This map shows the direct air route between Tupelo and De Lisle. Straight-line distance: 269.98 mi (434.49 km).
#1 Tupelo
City in and county seat of Lee County, Mississippi, United States
| Population | 38,303 |
| Coordinates | 34.2580700, -88.7046400 |
| Altitude | 85 |
| Country | United States |
#2 De Lisle
De Lisle is a place in Mississippi, United States.
| Population | 0 |
| Coordinates | 30.3793600, -89.2644900 |
| Altitude | 6 |
| Country | United States |
End: De Lisle (-89.26449, 30.37936)
Estimated Travel Time
Distance: 498 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 19m |
| 40 mph (64.37 km/h) | 07h 44m |
| 50 mph (80.47 km/h) | 06h 11m |
| 60 mph (96.56 km/h) | 05h 09m |
| 70 mph (112.65 km/h) | 04h 25m |
| 80 mph (129 km/h) | 03h 51m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.73 | $40.78 | $81.56 |
| Mid-grade | $4.21 | $46.05 | $92.10 |
| Premium | $4.61 | $50.42 | $100.84 |
| Diesel | $5.80 | $63.38 | $126.77 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Nov 06, 2026