How far is De Lisle, MS from Tupelo, MS?
The driving distance from De Lisle, MS to Tupelo, MS is about 306.6 miles (493.5 km), with a travel time of about 04h 53m by car.
- The straight-line flight distance is about 270 miles (434.5 km).
- For a round trip, plan for roughly 09h 46m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CST.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 53m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Clarke County, Mississippi, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Driving Route Map
The map below follows the saved road route between De Lisle and Tupelo.
Turn-by-Turn Driving Directions
Step-by-step road directions between De Lisle and Tupelo.
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1
Start on Ball Park Road
21 m · 4 sec · Ball Park Road
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2
Turn right onto Cuevas-Delisle Road
1.6 mi · 4 min · Cuevas-Delisle Road
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3
At the end of the road, turn left onto Menge Avenue
1.3 mi · 3 min · Menge Avenue
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4
Take the ramp slight right
1677 ft · 41 sec
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5
Merge slight left
9.3 mi · 10 min
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6
Take the exit slight right toward US 49 North: Hattiesburg
1291 ft · 31 sec
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7
Continue straight
55.7 mi · 1 hr 7 min
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8
Continue straight
2.4 mi · 3 min
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9
Take the exit straight
1520 ft · 52 sec
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10
Merge slight left
2.5 mi · 3 min
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11
Take the exit slight right toward I 59 North, US 98 West: Columbia, Laurel
1.3 km · 2 min
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12
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
88.4 mi · 1 hr 35 min · Lance Corporal Roy M Wheat Memorial Highway
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13
Keep slight right to continue on I 59 North, I 20 East: Meridian, Tuscaloosa
9 mi · 11 min
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14
Take the exit slight right toward US 45 North: Macon
1383 ft · 47 sec
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15
Merge slight left
65.1 mi · 1 hr 14 min
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16
Keep slight left to continue on US Highway 45 Alternate
53 mi · 1 hr 4 min · US Highway 45 Alternate
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17
Continue on Martin Luther King Drive
18.1 mi · 21 min · Martin Luther King Drive
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18
Continue on Martin Luther King, Junior Drive
1.5 mi · 2 min · Martin Luther King, Junior Drive
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19
Take the exit slight right toward MS 6 East: Downtown Tupelo
2008 ft · 49 sec
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20
Keep slight left
52 m · 7 sec
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21
Turn left onto East Main Street
1.1 km · 2 min · East Main Street
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22
Turn right onto North Spring Street
70 m · 10 sec · North Spring Street
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23
Arrive at your destination
0 m · 1 sec · North Spring Street
Car Route Details
A richer read on the saved driving route between De Lisle and Tupelo.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Lance Corporal Roy M Wheat Memorial Highway
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
88.4 mi · 01h 35m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Sunny leaving De Lisle and Sunny near Tupelo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from De Lisle to Tupelo?
The road trip is about 306.6 miles (493.5 km) and usually takes 04h 53m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Enterprise is a useful midpoint, sitting about 155.7 miles from De Lisle and 151 miles from Tupelo.
How much longer is the road route than the straight-line distance?
The direct path is about 270 miles (434.5 km), while the road route adds roughly 36.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CST. If you want a more comfortable same-day return, try to leave by 7:14 AM CST.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $40.37 one way or $80.74 round trip. Estimated CO2 is about 96.2 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny around De Lisle and Sunny near Tupelo.
Stop Ideas Near Enterprise
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Enterprise.
Union Station
Laurel station
Hattiesburg, MS
Hattiesburg station
Flight Path Map
This map shows the direct air route between De Lisle and Tupelo. Straight-line distance: 269.98 mi (434.49 km).
#1 De Lisle
De Lisle is a place in Mississippi, United States.
| Population | 0 |
| Coordinates | 30.3793600, -89.2644900 |
| Altitude | 6 |
| Country | United States |
#2 Tupelo
City in and county seat of Lee County, Mississippi, United States
| Population | 38,303 |
| Coordinates | 34.2580700, -88.7046400 |
| Altitude | 85 |
| Country | United States |
End: North Spring Street (-88.704455, 34.258074)
Estimated Travel Time
Distance: 493 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 12m |
| 40 mph (64.37 km/h) | 07h 39m |
| 50 mph (80.47 km/h) | 06h 07m |
| 60 mph (96.56 km/h) | 05h 06m |
| 70 mph (112.65 km/h) | 04h 22m |
| 80 mph (129 km/h) | 03h 49m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.73 | $40.37 | $80.74 |
| Mid-grade | $4.21 | $45.58 | $91.17 |
| Premium | $4.61 | $49.91 | $99.83 |
| Diesel | $5.80 | $62.75 | $125.49 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Nov 06, 2026