How far is St. Louis, MO from Sikeston, MO?
The driving distance from St. Louis, MO to Sikeston, MO is about 145.2 miles (233.7 km), with a travel time of about 02h 43m by car.
- The straight-line flight distance is about 125.5 miles (201.9 km).
- For a round trip, plan for roughly 05h 26m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 43m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Sunny
Driving Route Map
The map below follows the saved road route between St. Louis and Sikeston.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and Sikeston.
-
1
Start on Market Street
26 m · 4 sec · Market Street
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2
Turn left onto South Tucker Boulevard
1.3 mi · 4 min · South Tucker Boulevard
-
3
Turn straight onto Gravois Avenue
1619 ft · 46 sec · Gravois Avenue
-
4
Take the ramp left toward I 55 South: Memphis
626 ft · 15 sec
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5
Merge slight left
140.1 mi · 2 hr 33 min
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6
Take the exit slight right toward US 62: Sikeston, Bertrand
1057 ft · 38 sec
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7
At the end of the road, turn left onto East Malone Avenue
3.1 mi · 5 min · East Malone Avenue
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8
Turn slight right
54 m · 14 sec
-
9
Turn left
33 m · 5 sec
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10
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between St. Louis and Sikeston.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 South
Merge slight left
140 mi · 02h 33m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Mostly Sunny leaving St. Louis and Sunny near Sikeston.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to Sikeston?
The road trip is about 145.2 miles (233.7 km) and usually takes 02h 43m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Saint Mary is a useful midpoint, sitting about 72.6 miles from St. Louis and 72.6 miles from Sikeston.
How much longer is the road route than the straight-line distance?
The direct path is about 125.5 miles (201.9 km), while the road route adds roughly 19.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 1:04 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $19.31 one way or $38.62 round trip. Estimated CO2 is about 45.5 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around St. Louis and Sunny near Sikeston.
Stop Ideas Near Saint Mary
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Saint Mary.
Du Quoin
Carbondale station
Gateway Transportation Center
Kirkwood
Flight Path Map
This map shows the direct air route between St. Louis and Sikeston. Straight-line distance: 125.45 mi (201.9 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 Sikeston
City in Scott County, Missouri, United States
| Population | 15,968 |
| Coordinates | 36.8767200, -89.5878600 |
| Altitude | 100 |
| Country | United States |
End: Sikeston (-89.58786, 36.87672)
Estimated Travel Time
Distance: 234 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 04h 50m |
| 40 mph (64.37 km/h) | 03h 37m |
| 50 mph (80.47 km/h) | 02h 54m |
| 60 mph (96.56 km/h) | 02h 25m |
| 70 mph (112.65 km/h) | 02h 04m |
| 80 mph (129 km/h) | 01h 48m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $19.31 | $38.62 |
| Mid-grade | $4.25 | $21.78 | $43.55 |
| Premium | $4.65 | $23.83 | $47.66 |
| Diesel | $5.30 | $27.16 | $54.31 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.