How far is St. Louis, MO from Seneca, MO?
The driving distance from St. Louis, MO to Seneca, MO is about 300.1 miles (483 km), with a travel time of about 05h 36m by car.
- The straight-line flight distance is about 270.9 miles (435.9 km).
- For a round trip, plan for roughly 11h 13m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 36m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny
Showers And Thunderstorms Likely
Driving Route Map
The map below follows the saved road route between St. Louis and Seneca.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and Seneca.
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1
Start on Market Street
1.6 km · 2 min · Market Street
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2
Turn left onto South Jefferson Avenue
1.2 mi · 3 min · South Jefferson Avenue
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3
Take the ramp straight toward I 44 West
1051 ft · 17 sec
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4
Merge slight left onto Officer David Haynes Memorial Highway
2.3 mi · 3 min · Officer David Haynes Memorial Highway
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5
Continue on Officer Michael Barwick Memorial Highway
3.5 mi · 4 min · Officer Michael Barwick Memorial Highway
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6
Continue on Police Officer Robert Stanze Memorial Highway
2.7 mi · 3 min · Police Officer Robert Stanze Memorial Highway
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7
Continue on Police Officer Ernest M. Brockman Sr. Memorial Highway
3.5 mi · 4 min · Police Officer Ernest M. Brockman Sr. Memorial Highway
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8
Continue on Henry Shaw Ozark Corridor
266.5 mi · 4 hr 50 min · Henry Shaw Ozark Corridor
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9
Continue on George Washington Carver Memorial Highway
6.3 mi · 7 min · George Washington Carver Memorial Highway
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10
Take the exit slight right toward MO 43 South: Seneca
744 ft · 18 sec
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11
Keep slight left to continue on MO 43 South: Seneca
112 m · 13 sec
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12
Continue on Coyote Drive
2303 ft · 47 sec · Coyote Drive
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13
Continue on Cherokee Avenue
12.2 mi · 19 min · Cherokee Avenue
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14
Turn left onto Delaware Street
15 m · 2 sec · Delaware Street
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15
Arrive at your destination
0 m · 1 sec · Delaware Street
Car Route Details
A richer read on the saved driving route between St. Louis and Seneca.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Henry Shaw Ozark Corridor
Continue on Henry Shaw Ozark Corridor
267 mi · 04h 50m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Sunny leaving St. Louis and Showers And Thunderstorms Likely near Seneca.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to Seneca?
The road trip is about 300.1 miles (483 km) and usually takes 05h 36m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Stoutland is a useful midpoint, sitting about 149.9 miles from St. Louis and 150.2 miles from Seneca.
How much longer is the road route than the straight-line distance?
The direct path is about 270.9 miles (435.9 km), while the road route adds roughly 29.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 5:46 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $39.93 one way or $79.87 round trip. Estimated CO2 is about 94.1 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny around St. Louis and Showers And Thunderstorms Likely near Seneca.
Stop Ideas Near Stoutland
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Stoutland.
Jefferson City
Sedalia
Flight Path Map
This map shows the direct air route between St. Louis and Seneca. Straight-line distance: 270.84 mi (435.87 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 Seneca
City in Missouri
| Population | 2,394 |
| Coordinates | 36.8414600, -94.6110600 |
| Altitude | 258 |
| Country | United States |
End: Seneca (-94.61106, 36.84146)
Estimated Travel Time
Distance: 483 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 59m |
| 40 mph (64.37 km/h) | 07h 30m |
| 50 mph (80.47 km/h) | 06h 00m |
| 60 mph (96.56 km/h) | 05h 00m |
| 70 mph (112.65 km/h) | 04h 17m |
| 80 mph (129 km/h) | 03h 44m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $39.93 | $79.87 |
| Mid-grade | $4.25 | $45.04 | $90.08 |
| Premium | $4.65 | $49.29 | $98.57 |
| Diesel | $5.30 | $56.17 | $112.34 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 30, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.