How far is St. Louis, MO from Salisbury, MO?
The driving distance from St. Louis, MO to Salisbury, MO is about 179.3 miles (288.5 km), with a travel time of about 03h 39m by car.
- The straight-line flight distance is about 150.2 miles (241.7 km).
- For a round trip, plan for roughly 07h 18m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 39m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny then Slight Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between St. Louis and Salisbury.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and Salisbury.
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1
Start on Market Street
1.6 mi · 3 min · Market Street
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2
Take the ramp slight left toward I 64 West, US 40 West: Wentzville
1531 ft · 24 sec
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3
Merge slight left onto Jack Buck Memorial Highway
4.3 mi · 6 min · Jack Buck Memorial Highway
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4
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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5
Continue on Avenue of the Saints
27.8 mi · 34 min · Avenue of the Saints
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6
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
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7
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 1 hr 35 min · Dwight D Eisenhower Highway
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8
Take the exit slight right toward US 63: Jefferson City, Moberly
1058 ft · 23 sec
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9
Turn right onto US 63 North: Moberly
53 m · 4 sec
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10
Merge slight left
1 km · 1 min
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11
Merge slight left
35.6 mi · 38 min
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12
Take the exit slight right toward US 24: Moberly
1076 ft · 31 sec
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13
Turn slight right
35 m · 3 sec
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14
Turn right
21 mi · 31 min
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15
Turn left onto North Weber Avenue
2216 ft · 47 sec · North Weber Avenue
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16
Turn right onto East 2nd Street
859 ft · 24 sec · East 2nd Street
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17
Arrive at your destination
0 m · 1 sec · West 2nd Street
Car Route Details
A richer read on the saved driving route between St. Louis and Salisbury.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Dwight D Eisenhower Highway
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 01h 35m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving St. Louis and Sunny then Slight Chance Showers And Thunderstorms near Salisbury.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to Salisbury?
The road trip is about 179.3 miles (288.5 km) and usually takes 03h 39m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Auxvasse is a useful midpoint, sitting about 89.5 miles from St. Louis and 89.7 miles from Salisbury.
How much longer is the road route than the straight-line distance?
The direct path is about 150.2 miles (241.7 km), while the road route adds roughly 29.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 9:42 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $23.83 one way or $47.67 round trip. Estimated CO2 is about 56.2 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around St. Louis and Sunny then Slight Chance Showers And Thunderstorms near Salisbury.
Stop Ideas Near Auxvasse
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Auxvasse.
Hermann
Jefferson City
Washington
Quincy
Flight Path Map
This map shows the direct air route between St. Louis and Salisbury. Straight-line distance: 150.2 mi (241.72 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 Salisbury
City in Chariton County, Missouri, USA
| Population | 1,510 |
| Coordinates | 39.4239200, -92.8015800 |
| Altitude | 226 |
| Country | United States |
End: Salisbury (-92.80158, 39.42392)
Estimated Travel Time
Distance: 288 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 58m |
| 40 mph (64.37 km/h) | 04h 28m |
| 50 mph (80.47 km/h) | 03h 35m |
| 60 mph (96.56 km/h) | 02h 59m |
| 70 mph (112.65 km/h) | 02h 33m |
| 80 mph (129 km/h) | 02h 14m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $23.83 | $47.67 |
| Mid-grade | $4.25 | $26.88 | $53.76 |
| Premium | $4.65 | $29.41 | $58.83 |
| Diesel | $5.30 | $33.52 | $67.04 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 12, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.