How far is St. Louis, MO from Milan, MO?
The driving distance from St. Louis, MO to Milan, MO is about 240.6 miles (387.2 km), with a travel time of about 05h 00m by car.
- The straight-line flight distance is about 190.4 miles (306.4 km).
- For a round trip, plan for roughly 10h 01m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 00m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Village in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Showers And Thunderstorms Likely
Driving Route Map
The map below follows the saved road route between St. Louis and Milan.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and Milan.
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1
Start on Market Street
1.6 mi · 3 min · Market Street
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2
Take the ramp slight left toward I 64 West, US 40 West: Wentzville
1531 ft · 24 sec
-
3
Merge slight left onto Jack Buck Memorial Highway
4.3 mi · 6 min · Jack Buck Memorial Highway
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4
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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5
Continue on Avenue of the Saints
101.2 mi · 2 hr 1 min · Avenue of the Saints
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6
Take the exit slight left
76 m · 15 sec
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7
Turn left onto Paris Gravel Road
2645 ft · 1 min · Paris Gravel Road
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8
Keep slight right to continue on County Road 422
85 m · 9 sec · County Road 422
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9
Turn right onto Veterans Road
2.2 mi · 4 min · Veterans Road
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10
Take the ramp left toward US 36 West, MO 110 West: Monroe City
1226 ft · 16 sec
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11
Merge slight left onto V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
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12
Continue on Chicago-Kansas City Expressway
52.9 mi · 1 hr 1 min · Chicago-Kansas City Expressway
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13
Take the exit slight right toward US 63: Macon, Kirksville
1054 ft · 29 sec
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14
Turn right onto North Missouri Street
28.5 mi · 32 min · North Missouri Street
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15
Take the exit slight right toward US 63 Business: Kirksville
1 km · 1 min
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16
Continue on South Baltimore Street
4.7 mi · 8 min · South Baltimore Street
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17
Turn left onto West Potter Avenue
1.1 mi · 2 min · West Potter Avenue
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18
Continue on Potter Trail
1.6 mi · 3 min · Potter Trail
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19
Turn left
27.9 mi · 42 min
-
20
Turn left onto North Pearl Street
1.1 km · 1 min · North Pearl Street
-
21
Turn right onto East 3rd Street
2192 ft · 44 sec · East 3rd Street
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22
Arrive at your destination
0 m · 1 sec · East 3rd Street
Car Route Details
A richer read on the saved driving route between St. Louis and Milan.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Avenue of the Saints
Continue on Avenue of the Saints
101 mi · 02h 01m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving St. Louis and Showers And Thunderstorms Likely near Milan.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to Milan?
The road trip is about 240.6 miles (387.2 km) and usually takes 05h 00m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Rensselaer is a useful midpoint, sitting about 120.2 miles from St. Louis and 120.4 miles from Milan.
How much longer is the road route than the straight-line distance?
The direct path is about 190.4 miles (306.4 km), while the road route adds roughly 50.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:58 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $32.02 one way or $64.03 round trip. Estimated CO2 is about 75.5 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around St. Louis and Showers And Thunderstorms Likely near Milan.
Stop Ideas Near Rensselaer
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Rensselaer.
Quincy
La Plata
Fort Madison station
Hermann
Flight Path Map
This map shows the direct air route between St. Louis and Milan. Straight-line distance: 190.4 mi (306.42 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 Milan
City in Missouri, USA
| Population | 1,764 |
| Coordinates | 40.2022400, -93.1252100 |
| Altitude | 297 |
| Country | United States |
End: Milan (-93.12521, 40.20224)
Estimated Travel Time
Distance: 387 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 08h 01m |
| 40 mph (64.37 km/h) | 06h 00m |
| 50 mph (80.47 km/h) | 04h 48m |
| 60 mph (96.56 km/h) | 04h 00m |
| 70 mph (112.65 km/h) | 03h 26m |
| 80 mph (129 km/h) | 03h 00m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $32.02 | $64.03 |
| Mid-grade | $4.25 | $36.11 | $72.22 |
| Premium | $4.65 | $39.51 | $79.02 |
| Diesel | $5.30 | $45.03 | $90.06 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.