How far is St. Louis, MO from Humansville, MO?
The driving distance from St. Louis, MO to Humansville, MO is about 225.4 miles (362.7 km), with a travel time of about 04h 31m by car.
- The straight-line flight distance is about 192.3 miles (309.5 km).
- For a round trip, plan for roughly 09h 02m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 31m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Phelps County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms Likely then Chance Showers And Thunderstorms
Mostly Sunny then Slight Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between St. Louis and Humansville.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and Humansville.
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1
Start on Market Street
1.6 km · 2 min · Market Street
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2
Turn left onto South Jefferson Avenue
1.2 mi · 3 min · South Jefferson Avenue
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3
Take the ramp straight toward I 44 West
1051 ft · 17 sec
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4
Merge slight left onto Officer David Haynes Memorial Highway
2.3 mi · 3 min · Officer David Haynes Memorial Highway
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5
Continue on Officer Michael Barwick Memorial Highway
3.5 mi · 4 min · Officer Michael Barwick Memorial Highway
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6
Continue on Police Officer Robert Stanze Memorial Highway
2.7 mi · 3 min · Police Officer Robert Stanze Memorial Highway
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7
Continue on Police Officer Ernest M. Brockman Sr. Memorial Highway
3.5 mi · 4 min · Police Officer Ernest M. Brockman Sr. Memorial Highway
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8
Continue on Henry Shaw Ozark Corridor
147.9 mi · 2 hr 41 min · Henry Shaw Ozark Corridor
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9
Take the exit slight right toward MO 32, MO 5, MO 64: Hartville
932 ft · 20 sec
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10
Turn right onto South Jefferson Avenue
1 mi · 2 min · South Jefferson Avenue
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11
Turn left onto West Commercial Street
4.3 mi · 7 min · West Commercial Street
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12
Continue straight
42.8 mi · 1 hr 2 min
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13
Take the ramp right toward MO 13 North: Humansville
1598 ft · 39 sec
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14
Merge slight left
11.9 mi · 14 min
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15
Turn right
2.4 mi · 4 min
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16
Turn left onto East Tilden Street
145 m · 11 sec · East Tilden Street
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17
Arrive at your destination
0 m · 1 sec · West Tilden Street
Car Route Details
A richer read on the saved driving route between St. Louis and Humansville.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Henry Shaw Ozark Corridor
Continue on Henry Shaw Ozark Corridor
148 mi · 02h 41m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms Likely then Chance Showers And Thunderstorms leaving St. Louis and Mostly Sunny then Slight Chance Showers And Thunderstorms near Humansville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to Humansville?
The road trip is about 225.4 miles (362.7 km) and usually takes 04h 31m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Doolittle is a useful midpoint, sitting about 112.5 miles from St. Louis and 112.8 miles from Humansville.
How much longer is the road route than the straight-line distance?
The direct path is about 192.3 miles (309.5 km), while the road route adds roughly 33.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 7:58 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $29.98 one way or $59.96 round trip. Estimated CO2 is about 70.7 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms Likely then Chance Showers And Thunderstorms around St. Louis and Mostly Sunny then Slight Chance Showers And Thunderstorms near Humansville.
Stop Ideas Near Doolittle
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Doolittle.
Jefferson City
Hermann
Washington
Flight Path Map
This map shows the direct air route between St. Louis and Humansville. Straight-line distance: 192.3 mi (309.47 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 Humansville
City in Polk County, Missouri, United States
| Population | 1,070 |
| Coordinates | 37.7944800, -93.5779800 |
| Altitude | 294 |
| Country | United States |
End: Humansville (-93.57798, 37.79448)
Estimated Travel Time
Distance: 363 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 30m |
| 40 mph (64.37 km/h) | 05h 38m |
| 50 mph (80.47 km/h) | 04h 30m |
| 60 mph (96.56 km/h) | 03h 45m |
| 70 mph (112.65 km/h) | 03h 13m |
| 80 mph (129 km/h) | 02h 48m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $29.98 | $59.96 |
| Mid-grade | $4.25 | $33.81 | $67.62 |
| Premium | $4.65 | $37.00 | $74.00 |
| Diesel | $5.30 | $42.17 | $84.33 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 04, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.