How far is St. Louis, MO from Duquesne, MO?
The driving distance from St. Louis, MO to Duquesne, MO is about 281.7 miles (453.4 km), with a travel time of about 05h 14m by car.
- The straight-line flight distance is about 255.9 miles (411.9 km).
- For a round trip, plan for roughly 10h 29m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 14m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Pulaski County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny then Slight Chance Rain Showers
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between St. Louis and Duquesne.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and Duquesne.
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1
Start on Market Street
1.6 km · 2 min · Market Street
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2
Turn left onto South Jefferson Avenue
1.2 mi · 3 min · South Jefferson Avenue
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3
Take the ramp straight toward I 44 West
1051 ft · 17 sec
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4
Merge slight left onto Officer David Haynes Memorial Highway
2.3 mi · 3 min · Officer David Haynes Memorial Highway
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5
Continue on Officer Michael Barwick Memorial Highway
3.5 mi · 4 min · Officer Michael Barwick Memorial Highway
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6
Continue on Police Officer Robert Stanze Memorial Highway
2.7 mi · 3 min · Police Officer Robert Stanze Memorial Highway
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7
Continue on Police Officer Ernest M. Brockman Sr. Memorial Highway
3.5 mi · 4 min · Police Officer Ernest M. Brockman Sr. Memorial Highway
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8
Continue on Henry Shaw Ozark Corridor
261.3 mi · 4 hr 44 min · Henry Shaw Ozark Corridor
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9
Take the exit slight right toward I 44 Business, MO 66: Duenweg, Joplin
5.5 mi · 10 min
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10
Turn left onto Duquesne Road
2590 ft · 1 min · Duquesne Road
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11
Arrive at your destination
0 m · 1 sec · Duquesne Road
Car Route Details
A richer read on the saved driving route between St. Louis and Duquesne.
Straightforward drive
The saved road route has a manageable number of maneuvers and should be easy to follow with normal attention to signs.
Henry Shaw Ozark Corridor
Continue on Henry Shaw Ozark Corridor
261 mi · 04h 44m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Sunny then Slight Chance Rain Showers leaving St. Louis and Chance Showers And Thunderstorms near Duquesne.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to Duquesne?
The road trip is about 281.7 miles (453.4 km) and usually takes 05h 14m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Waynesville is a useful midpoint, sitting about 140.7 miles from St. Louis and 141.1 miles from Duquesne.
How much longer is the road route than the straight-line distance?
The direct path is about 255.9 miles (411.9 km), while the road route adds roughly 25.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:30 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $37.48 one way or $74.97 round trip. Estimated CO2 is about 88.3 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny then Slight Chance Rain Showers around St. Louis and Chance Showers And Thunderstorms near Duquesne.
Stop Ideas Near Waynesville
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Waynesville.
Jefferson City
Hermann
Flight Path Map
This map shows the direct air route between St. Louis and Duquesne. Straight-line distance: 255.95 mi (411.91 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 Duquesne
City in Jasper County, Missouri, United States of America
| Population | 1,689 |
| Coordinates | 37.0767300, -94.4593900 |
| Altitude | 327 |
| Country | United States |
End: Duquesne (-94.45939, 37.07673)
Estimated Travel Time
Distance: 453 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 23m |
| 40 mph (64.37 km/h) | 07h 02m |
| 50 mph (80.47 km/h) | 05h 38m |
| 60 mph (96.56 km/h) | 04h 41m |
| 70 mph (112.65 km/h) | 04h 01m |
| 80 mph (129 km/h) | 03h 30m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $37.48 | $74.97 |
| Mid-grade | $4.25 | $42.27 | $84.55 |
| Premium | $4.65 | $46.26 | $92.52 |
| Diesel | $5.30 | $52.72 | $105.44 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 27, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.