How far is Sikeston, MO from Chesterfield, MO?
The driving distance from Sikeston, MO to Chesterfield, MO is about 153.4 miles (246.9 km), with a travel time of about 02h 19m by car.
- The straight-line flight distance is about 134.7 miles (216.8 km).
- For a round trip, plan for roughly 04h 38m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 19m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Sikeston and Chesterfield.
Turn-by-Turn Driving Directions
Step-by-step road directions between Sikeston and Chesterfield.
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1
Start on the route
8 m · 9 sec
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2
Turn sharp left onto East Malone Avenue
3.2 mi · 5 min · East Malone Avenue
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3
Take the ramp slight right toward I 55 North: Cape Girardeau
1484 ft · 36 sec
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4
Merge slight left
26.1 mi · 28 min
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5
Keep slight left
101.5 mi · 1 hr 49 min
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6
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
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7
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
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8
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
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9
Continue on I 270 West
1.2 km · 1 min
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10
Merge slight left
11.5 mi · 14 min
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11
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
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12
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
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13
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
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14
Merge slight left onto Avenue of the Saints
5.9 mi · 7 min · Avenue of the Saints
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15
Take the exit slight right toward Chesterfield Parkway West
116 m · 8 sec
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16
Turn straight onto North Outer 40
2036 ft · 56 sec · North Outer 40
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17
Turn left onto Chesterfield Parkway West
607 ft · 27 sec · Chesterfield Parkway West
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18
Turn right
1674 ft · 33 sec
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19
Turn straight onto Wild Horse Creek Road
48 m · 4 sec · Wild Horse Creek Road
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20
Turn right onto Old Chesterfield Road
1576 ft · 1 min · Old Chesterfield Road
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21
Turn left onto Santa Maria Drive
33 m · 5 sec · Santa Maria Drive
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22
Arrive at your destination
0 m · 1 sec · Santa Maria Drive
Car Route Details
A richer read on the saved driving route between Sikeston and Chesterfield.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 North
Keep slight left
102 mi · 01h 49m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Sunny leaving Sikeston and Sunny near Chesterfield.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Sikeston to Chesterfield?
The road trip is about 153.4 miles (246.9 km) and usually takes 02h 19m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Saint Mary is a useful midpoint, sitting about 76.4 miles from Sikeston and 76.9 miles from Chesterfield.
How much longer is the road route than the straight-line distance?
The direct path is about 134.7 miles (216.8 km), while the road route adds roughly 18.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 1:52 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $20.40 one way or $40.80 round trip. Estimated CO2 is about 48.1 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Sikeston and Sunny near Chesterfield.
Stop Ideas Near Saint Mary
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Saint Mary.
Du Quoin
Carbondale station
Gateway Transportation Center
Kirkwood
Flight Path Map
This map shows the direct air route between Sikeston and Chesterfield. Straight-line distance: 134.73 mi (216.83 km).
#1 Sikeston
City in Scott County, Missouri, United States
| Population | 15,968 |
| Coordinates | 36.8767200, -89.5878600 |
| Altitude | 100 |
| Country | United States |
#2 Chesterfield
A city in St.
| Population | 47,570 |
| Coordinates | 38.6631100, -90.5770700 |
| Altitude | 144 |
| Country | United States |
End: Santa Maria Drive (-90.576914, 38.663102)
Estimated Travel Time
Distance: 247 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 06m |
| 40 mph (64.37 km/h) | 03h 50m |
| 50 mph (80.47 km/h) | 03h 04m |
| 60 mph (96.56 km/h) | 02h 33m |
| 70 mph (112.65 km/h) | 02h 11m |
| 80 mph (129 km/h) | 01h 54m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $20.40 | $40.80 |
| Mid-grade | $4.25 | $23.01 | $46.02 |
| Premium | $4.65 | $25.18 | $50.36 |
| Diesel | $5.30 | $28.69 | $57.39 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 12, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.