How far is Sikeston, MO from Independence, MO?
The driving distance from Sikeston, MO to Independence, MO is about 371.5 miles (597.9 km), with a travel time of about 05h 42m by car.
- The straight-line flight distance is about 304.1 miles (489.4 km).
- For a round trip, plan for roughly 11h 24m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 42m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Warren County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny then Slight Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Sikeston and Independence.
Turn-by-Turn Driving Directions
Step-by-step road directions between Sikeston and Independence.
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1
Start on the route
8 m · 9 sec
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2
Turn sharp left onto East Malone Avenue
3.2 mi · 5 min · East Malone Avenue
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3
Take the ramp slight right toward I 55 North: Cape Girardeau
1484 ft · 36 sec
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4
Merge slight left
26.1 mi · 28 min
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5
Keep slight left
101.5 mi · 1 hr 49 min
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6
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
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7
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
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8
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
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9
Continue on I 270 West
1.2 km · 1 min
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10
Merge slight left
11.5 mi · 14 min
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11
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
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12
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
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13
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
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14
Merge slight left onto Avenue of the Saints
25.4 mi · 31 min · Avenue of the Saints
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15
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
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16
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 1 hr 35 min · Dwight D Eisenhower Highway
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17
Continue on Sheriff Roger I. Wilson Memorial Highway
2 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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18
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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19
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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20
Continue on U.S. Submarine Veterans' Memorial Highway
54.4 mi · 58 min · U.S. Submarine Veterans' Memorial Highway
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21
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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22
Continue on Truman/Eisenhower Presidential Highway
2.7 mi · 3 min · Truman/Eisenhower Presidential Highway
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23
Continue on Clifton J. Scott Memorial Highway
1.4 mi · 2 min · Clifton J. Scott Memorial Highway
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24
Take the exit slight right toward Noland Road
1110 ft · 24 sec
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25
Turn right onto South Noland Road
3 mi · 5 min · South Noland Road
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26
Turn left onto East Walnut Street
142 m · 23 sec · East Walnut Street
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27
Turn right onto South Lynn Street
120 m · 23 sec · South Lynn Street
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28
Turn left onto East Kansas Avenue
44 m · 6 sec · East Kansas Avenue
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29
Arrive at your destination
0 m · 1 sec · East Kansas Avenue
Car Route Details
A richer read on the saved driving route between Sikeston and Independence.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 55 North
Keep slight left
102 mi · 01h 49m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Sikeston and Sunny then Slight Chance Showers And Thunderstorms near Independence.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Sikeston to Independence?
The road trip is about 371.5 miles (597.9 km) and usually takes 05h 42m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Truesdale is a useful midpoint, sitting about 185.9 miles from Sikeston and 185.7 miles from Independence.
How much longer is the road route than the straight-line distance?
The direct path is about 304.1 miles (489.4 km), while the road route adds roughly 67.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 5:36 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $49.44 one way or $98.88 round trip. Estimated CO2 is about 116.5 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Sikeston and Sunny then Slight Chance Showers And Thunderstorms near Independence.
Stop Ideas Near Truesdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Warrenton City Animal Control
Moscow Mills City Hall
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Truesdale.
Hermann
Washington
Kirkwood
Gateway Transportation Center
Flight Path Map
This map shows the direct air route between Sikeston and Independence. Straight-line distance: 304.12 mi (489.43 km).
#1 Sikeston
City in Scott County, Missouri, United States
| Population | 15,968 |
| Coordinates | 36.8767200, -89.5878600 |
| Altitude | 100 |
| Country | United States |
#2 Independence
A city in Jackson County, Missouri.
| Population | 116,774 |
| Coordinates | 39.0911200, -94.4155100 |
| Altitude | 315 |
| Country | United States |
End: East Kansas Avenue (-94.415514, 39.091027)
Estimated Travel Time
Distance: 598 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 12h 22m |
| 40 mph (64.37 km/h) | 09h 17m |
| 50 mph (80.47 km/h) | 07h 25m |
| 60 mph (96.56 km/h) | 06h 11m |
| 70 mph (112.65 km/h) | 05h 18m |
| 80 mph (129 km/h) | 04h 38m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $49.44 | $98.88 |
| Mid-grade | $4.25 | $55.76 | $111.51 |
| Premium | $4.65 | $61.01 | $122.03 |
| Diesel | $5.30 | $69.54 | $139.07 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 12, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.