How far is Santa Fe, TX from San Antonio, TX?
The driving distance from Santa Fe, TX to San Antonio, TX is about 232.1 miles (373.6 km), with a travel time of about 03h 36m by car.
- The straight-line flight distance is about 203.9 miles (328.2 km).
- For a round trip, plan for roughly 07h 13m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 36m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Colorado County, Texas, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Chance Showers And Thunderstorms then Slight Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Santa Fe and San Antonio.
Turn-by-Turn Driving Directions
Step-by-step road directions between Santa Fe and San Antonio.
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1
Start on Highway 6
2250 ft · 44 sec · Highway 6
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2
Turn right onto Farm-to-Market Road 1764
152 m · 9 sec · Farm-to-Market Road 1764
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3
Continue on FM 1764
1.5 mi · 2 min · FM 1764
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4
Turn left onto FM 646
3.5 mi · 6 min · FM 646
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5
Turn right
1.1 mi · 2 min
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6
Turn left onto Gulf Freeway Frontage Road
1.5 km · 2 min · Gulf Freeway Frontage Road
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7
Take the ramp slight left toward I 45 North
1035 ft · 25 sec
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8
Merge slight left onto South Gulf Freeway
28.3 mi · 33 min · South Gulf Freeway
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9
Take the exit slight left toward I 10 West: San Antonio
717 ft · 18 sec
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10
Merge slight left onto Katy Freeway
174.7 mi · 3 hr 2 min · Katy Freeway
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11
Keep slight left
12 mi · 13 min
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12
Keep slight left to continue on 90th Infantry Division Highway
1.2 km · 52 sec · 90th Infantry Division Highway
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13
Continue on Jose Lopez Freeway
1.6 mi · 2 min · Jose Lopez Freeway
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14
Take the exit slight right toward Commerce Street, Houston Street
790 ft · 19 sec
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15
Turn straight onto Interstate 10 East
1830 ft · 39 sec · Interstate 10 East
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16
Turn right onto East Houston Street
963 ft · 20 sec · East Houston Street
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17
Turn slight left onto East Commerce Street
4.3 mi · 7 min · East Commerce Street
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18
Turn left onto Military Plaza
119 m · 16 sec · Military Plaza
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19
Turn left onto Dolorosa Street
100 m · 8 sec · Dolorosa Street
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20
Arrive at your destination
0 m · 1 sec · Dolorosa Street
Car Route Details
A richer read on the saved driving route between Santa Fe and San Antonio.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Katy Freeway
Merge slight left onto Katy Freeway
175 mi · 03h 02m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms leaving Santa Fe and Chance Showers And Thunderstorms then Slight Chance Showers And Thunderstorms near San Antonio.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Santa Fe to San Antonio?
The road trip is about 232.1 miles (373.6 km) and usually takes 03h 36m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Columbus is a useful midpoint, sitting about 115.1 miles from Santa Fe and 117.1 miles from San Antonio.
How much longer is the road route than the straight-line distance?
The direct path is about 203.9 miles (328.2 km), while the road route adds roughly 28.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 9:46 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $30.95 one way or $61.90 round trip. Estimated CO2 is about 72.8 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around Santa Fe and Chance Showers And Thunderstorms then Slight Chance Showers And Thunderstorms near San Antonio.
Stop Ideas Near Columbus
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Columbus.
Prairie View, TX
Bryan, TX
Houston
Houston, TX
Flight Path Map
This map shows the direct air route between Santa Fe and San Antonio. Straight-line distance: 203.95 mi (328.22 km).
#1 Santa Fe
City in Galveston County, Texas, United States
| Population | 13,461 |
| Coordinates | 29.3780100, -95.1057600 |
| Altitude | 9 |
| Country | United States |
#2 San Antonio
The seventh most populous city in the United States and the center of the San Antonio metropolitan area.
| Population | 1,567,118 |
| Coordinates | 29.4241200, -98.4936300 |
| Altitude | 198 |
| Country | United States |
End: Dolorosa Street (-98.493645, 29.424163)
Estimated Travel Time
Distance: 374 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 44m |
| 40 mph (64.37 km/h) | 05h 48m |
| 50 mph (80.47 km/h) | 04h 38m |
| 60 mph (96.56 km/h) | 03h 52m |
| 70 mph (112.65 km/h) | 03h 18m |
| 80 mph (129 km/h) | 02h 53m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.78 | $30.95 | $61.90 |
| Mid-grade | $4.25 | $34.82 | $69.65 |
| Premium | $4.59 | $37.60 | $75.20 |
| Diesel | $3.99 | $32.70 | $65.41 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.