How far is Santa Ana, CA from Mission District, CA?
The driving distance from Santa Ana, CA to Mission District, CA is about 413.8 miles (666 km), with a travel time of about 07h 44m by car.
- The straight-line flight distance is about 376.8 miles (606.4 km).
- For a round trip, plan for roughly 15h 29m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM PDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 07h 44m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Kings County, California
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Santa Ana and Mission District.
Turn-by-Turn Driving Directions
Step-by-step road directions between Santa Ana and Mission District.
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1
Start on West 1st Street
576 ft · 16 sec · West 1st Street
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2
Turn right onto North Broadway
1.5 mi · 3 min · North Broadway
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3
Turn right onto West Santa Clara Avenue
615 ft · 14 sec · West Santa Clara Avenue
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4
Continue on I 5 North: Los Angeles
1787 ft · 27 sec
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5
Merge slight left onto Santa Ana Freeway
8.9 mi · 10 min · Santa Ana Freeway
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6
Keep slight right to continue on Santa Ana Freeway
18 mi · 21 min · Santa Ana Freeway
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7
Keep slight right to continue on Golden State Freeway
25.5 mi · 30 min · Golden State Freeway
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8
Keep slight left to continue on Golden State Freeway
2.2 mi · 3 min · Golden State Freeway
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9
Keep slight right to continue on I 5 Truck North, CA 14 Truck
1.5 mi · 2 min
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10
Keep slight left
36.1 mi · 42 min
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11
Keep slight left to continue on Golden State Freeway
22.3 mi · 25 min · Golden State Freeway
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12
Keep slight right to continue on Westside Freeway
225.6 mi · 4 hr 2 min · Westside Freeway
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13
Keep slight left to continue on William Elton Brown Freeway
15.9 mi · 17 min · William Elton Brown Freeway
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14
Keep slight right to continue on William Elton Brown Freeway
1.1 mi · 1 min · William Elton Brown Freeway
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15
Merge slight left onto Arthur H. Breed Junior Freeway
18 mi · 21 min · Arthur H. Breed Junior Freeway
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16
Keep slight right to continue on Arthur H. Breed Junior Freeway
11.6 mi · 13 min · Arthur H. Breed Junior Freeway
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17
Keep slight right to continue on MacArthur Freeway
8.3 mi · 10 min · MacArthur Freeway
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18
Keep slight left to continue on MacArthur Freeway
7.2 mi · 8 min · MacArthur Freeway
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19
Take the exit slight left toward I 80 West: San Francisco
1.5 km · 1 min
-
20
Merge slight right onto Dwight D. Eisenhower Highway
1015 ft · 17 sec · Dwight D. Eisenhower Highway
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21
Turn slight left onto Dwight D. Eisenhower Highway
1959 ft · 33 sec · Dwight D. Eisenhower Highway
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22
Keep slight left to continue on Dwight D. Eisenhower Highway
5.5 mi · 8 min · Dwight D. Eisenhower Highway
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23
Continue on Route 80
1438 ft · 24 sec · Route 80
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24
Continue on Route 80
1.2 km · 1 min · Route 80
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25
Take the exit slight right toward Ninth Street, Civic Center
800 ft · 14 sec
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26
Keep slight right to continue on 9th Street, Civic Center
88 m · 7 sec
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27
Continue on Harrison Street
1.1 km · 2 min · Harrison Street
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28
Turn right onto 16th Street
635 ft · 20 sec · 16th Street
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29
Turn left onto Folsom Street
1176 ft · 38 sec · Folsom Street
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30
Turn right onto 18th Street
1263 ft · 48 sec · 18th Street
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31
Turn left onto Mission Street
699 ft · 32 sec · Mission Street
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32
Arrive at your destination
0 m · 1 sec · Mission Street
Car Route Details
A richer read on the saved driving route between Santa Ana and Mission District.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Westside Freeway
Keep slight right to continue on Westside Freeway
226 mi · 04h 02m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Santa Ana and Sunny near Mission District.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Santa Ana to Mission District?
The road trip is about 413.8 miles (666 km) and usually takes 07h 44m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Kettleman City is a useful midpoint, sitting about 206.9 miles from Santa Ana and 207 miles from Mission District.
How much longer is the road route than the straight-line distance?
The direct path is about 376.8 miles (606.4 km), while the road route adds roughly 37 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM PDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $91.41 one way or $182.82 round trip. Estimated CO2 is about 129.8 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Santa Ana and Sunny near Mission District.
Stop Ideas Near Kettleman City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kettleman City.
Kettleman City, California
Lemoore, California
Corcoran station
Lemoore (Naval Air Station), California
Flight Path Map
This map shows the direct air route between Santa Ana and Mission District. Straight-line distance: 376.81 mi (606.41 km).
#1 Santa Ana
The most populous city in Orange County, California and the center of the Santa Ana metropolitan area.
| Population | 331,301 |
| Coordinates | 33.7455700, -117.8678300 |
| Altitude | 35 |
| Country | United States |
#2 Mission District
Located in a sheltered valley in east-central San Francisco at an approximate elevation of 46 feet, this neighborhood generally experiences a sunnier microclimate than surrounding areas.
| Population | 0 |
| Coordinates | 37.7599300, -122.4191400 |
| Altitude | 14 |
| Country | United States |
End: Mission District (-122.41914, 37.75993)
Estimated Travel Time
Distance: 666 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 13h 47m |
| 40 mph (64.37 km/h) | 10h 20m |
| 50 mph (80.47 km/h) | 08h 16m |
| 60 mph (96.56 km/h) | 06h 53m |
| 70 mph (112.65 km/h) | 05h 54m |
| 80 mph (129 km/h) | 05h 09m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $6.26 | $91.41 | $182.82 |
| Mid-grade | $6.50 | $94.89 | $189.77 |
| Premium | $6.69 | $97.66 | $195.32 |
| Diesel | $8.41 | $122.83 | $245.66 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in California · Oct 15, 2026