How far is Mission District, CA from Santa Ana, CA?
The driving distance from Mission District, CA to Santa Ana, CA is about 414.7 miles (667.4 km), with a travel time of about 07h 06m by car.
- The straight-line flight distance is about 376.8 miles (606.4 km).
- For a round trip, plan for roughly 14h 13m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM PDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 07h 06m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Kings County, California
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Mission District and Santa Ana.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mission District and Santa Ana.
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1
Start on Mission Street
699 ft · 36 sec · Mission Street
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2
Turn right onto 18th Street
1263 ft · 48 sec · 18th Street
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3
Turn left onto Folsom Street
1176 ft · 38 sec · Folsom Street
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4
Turn right onto 16th Street
1397 ft · 37 sec · 16th Street
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5
Turn left onto Bryant Street
3120 ft · 2 min · Bryant Street
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6
Take the ramp left toward I 80 East: Oakland
1538 ft · 26 sec
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7
Merge slight right onto Route 80
1.5 km · 1 min · Route 80
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8
Continue on Dwight D. Eisenhower Highway
5.8 mi · 9 min · Dwight D. Eisenhower Highway
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9
Take the exit slight right toward I 580 East: Downtown Oakland, Hayward-Stockton
1.6 km · 1 min
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10
Merge slight left onto MacArthur Freeway
15.9 mi · 18 min · MacArthur Freeway
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11
Merge slight left onto Arthur H. Breed Junior Freeway
11.5 mi · 13 min · Arthur H. Breed Junior Freeway
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12
Keep slight right to continue on Arthur H. Breed Junior Freeway
17.8 mi · 21 min · Arthur H. Breed Junior Freeway
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13
Keep slight right to continue on William Elton Brown Freeway
11.1 mi · 12 min · William Elton Brown Freeway
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14
Keep slight left to continue on William Elton Brown Freeway
5.9 mi · 6 min · William Elton Brown Freeway
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15
Merge slight left onto Westside Freeway
224.4 mi · 4 hr · Westside Freeway
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16
Keep slight right
58.4 mi · 1 hr 7 min
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17
Keep slight left to continue on Golden State Freeway
4.1 mi · 5 min · Golden State Freeway
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18
Keep slight right to continue on I 405 South
1354 ft · 18 sec
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19
Keep slight left
24.7 mi · 29 min
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20
Keep slight left to continue on Golden State Freeway
1.3 mi · 2 min · Golden State Freeway
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21
Merge slight left onto Santa Ana Freeway
25.7 mi · 30 min · Santa Ana Freeway
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22
Keep slight right to continue on Santa Ana Freeway
1241 ft · 16 sec · Santa Ana Freeway
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23
Take the exit slight right toward Broadway, Main Street, Santa Ana
1.3 km · 57 sec
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24
Keep slight right to continue on Main Street North, Broadway
1656 ft · 22 sec
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25
Turn straight onto North Broadway
1.3 mi · 3 min · North Broadway
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26
Turn left onto West 5th Street
639 ft · 17 sec · West 5th Street
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27
Turn right onto North Main Street
1209 ft · 31 sec · North Main Street
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28
Turn right onto West 1st Street
16 m · 1 sec · West 1st Street
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29
Arrive at your destination
0 m · 1 sec · West 1st Street
Car Route Details
A richer read on the saved driving route between Mission District and Santa Ana.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Westside Freeway
Merge slight left onto Westside Freeway
224 mi · 04h 00m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Mission District and Sunny near Santa Ana.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mission District to Santa Ana?
The road trip is about 414.7 miles (667.4 km) and usually takes 07h 06m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Kettleman City is a useful midpoint, sitting about 206.7 miles from Mission District and 208 miles from Santa Ana.
How much longer is the road route than the straight-line distance?
The direct path is about 376.8 miles (606.4 km), while the road route adds roughly 37.9 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM PDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $91.60 one way or $183.20 round trip. Estimated CO2 is about 130 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Mission District and Sunny near Santa Ana.
Stop Ideas Near Kettleman City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kettleman City.
Kettleman City, California
Lemoore, California
Corcoran station
Lemoore (Naval Air Station), California
Flight Path Map
This map shows the direct air route between Mission District and Santa Ana. Straight-line distance: 376.81 mi (606.41 km).
#1 Mission District
Located in a sheltered valley in east-central San Francisco at an approximate elevation of 46 feet, this neighborhood generally experiences a sunnier microclimate than surrounding areas.
| Population | 0 |
| Coordinates | 37.7599300, -122.4191400 |
| Altitude | 14 |
| Country | United States |
#2 Santa Ana
The most populous city in Orange County, California and the center of the Santa Ana metropolitan area.
| Population | 331,301 |
| Coordinates | 33.7455700, -117.8678300 |
| Altitude | 35 |
| Country | United States |
End: West 1st Street (-117.86783, 33.745553)
Estimated Travel Time
Distance: 667 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 13h 49m |
| 40 mph (64.37 km/h) | 10h 22m |
| 50 mph (80.47 km/h) | 08h 17m |
| 60 mph (96.56 km/h) | 06h 54m |
| 70 mph (112.65 km/h) | 05h 55m |
| 80 mph (129 km/h) | 05h 10m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $6.26 | $91.60 | $183.20 |
| Mid-grade | $6.50 | $95.08 | $190.16 |
| Premium | $6.69 | $97.86 | $195.72 |
| Diesel | $8.41 | $123.08 | $246.16 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in California · Oct 15, 2026