How far is San Luis, AZ from Mesa, AZ?
The driving distance from San Luis, AZ to Mesa, AZ is about 225.2 miles (362.5 km), with a travel time of about 03h 38m by car.
- The straight-line flight distance is about 183.4 miles (295.1 km).
- For a round trip, plan for roughly 07h 17m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM MST.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 38m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Maricopa County, Arizona, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Driving Route Map
The map below follows the saved road route between San Luis and Mesa.
Turn-by-Turn Driving Directions
Step-by-step road directions between San Luis and Mesa.
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1
Start on Urtuzuastegui Street
6 m · 1 sec · Urtuzuastegui Street
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2
Enter the roundabout and take exit 1 toward Main Street
2 m · 1 sec · Main Street
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3
Exit the roundabout onto Main Street
1254 ft · 27 sec · Main Street
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4
Turn right onto East C Street
1312 ft · 42 sec · East C Street
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5
Turn left onto 4th Avenue
1371 ft · 31 sec · 4th Avenue
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6
Turn right onto East Cesar Chavez Boulevard
4.5 mi · 7 min · East Cesar Chavez Boulevard
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7
Continue on Robert A. Vaughan Expressway
20.9 mi · 24 min · Robert A. Vaughan Expressway
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8
Continue on South Araby Road
2412 ft · 31 sec · South Araby Road
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9
Enter the roundabout and take exit 2 toward Robert A. Vaughan Expressway
34 m · 2 sec
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10
Exit the rotary
2212 ft · 54 sec
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11
Merge slight left onto Blue Star Memorial Highway
143.4 mi · 2 hr 27 min · Blue Star Memorial Highway
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12
Take the exit slight right toward AZ 84 East: Maricopa
1294 ft · 35 sec
-
13
Turn left onto Gila Bend–Casa Grande Highway
5.7 mi · 7 min · Gila Bend–Casa Grande Highway
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14
Turn left onto South John Wayne Parkway
14.8 mi · 19 min · South John Wayne Parkway
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15
Continue on Maricopa Road
11.8 mi · 14 min · Maricopa Road
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16
Continue on West Queen Creek Road
5.3 mi · 8 min · West Queen Creek Road
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17
Turn left onto South Price Road
2.4 mi · 4 min · South Price Road
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18
Take the ramp straight toward AZ 101 Loop North
2496 ft · 33 sec
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19
Merge slight left onto Price Freeway
5.4 mi · 6 min · Price Freeway
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20
Take the exit slight right toward US 60 West, US 60 East: Phoenix, Globe
887 ft · 22 sec
-
21
Keep slight right to continue on US 60 East: Globe
1.2 km · 2 min
-
22
Merge slight left onto Superstition Freeway
2.9 mi · 3 min · Superstition Freeway
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23
Take the exit slight right toward Mesa Drive
2189 ft · 55 sec
-
24
Turn left onto South Mesa Drive
2 mi · 4 min · South Mesa Drive
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25
Continue on North Mesa Drive
2684 ft · 1 min · North Mesa Drive
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26
Turn right onto East University Drive
22 m · 2 sec · East University Drive
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27
Arrive at your destination
0 m · 1 sec · East University Drive
Car Route Details
A richer read on the saved driving route between San Luis and Mesa.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Blue Star Memorial Highway
Merge slight left onto Blue Star Memorial Highway
143 mi · 02h 27m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving San Luis and Sunny near Mesa.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from San Luis to Mesa?
The road trip is about 225.2 miles (362.5 km) and usually takes 03h 38m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Gila Bend is a useful midpoint, sitting about 111.6 miles from San Luis and 113.6 miles from Mesa.
How much longer is the road route than the straight-line distance?
The direct path is about 183.4 miles (295.1 km), while the road route adds roughly 41.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM MST. If you want a more comfortable same-day return, try to leave by 9:42 AM MST.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $39.36 one way or $78.72 round trip. Estimated CO2 is about 70.7 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around San Luis and Sunny near Mesa.
Stop Ideas Near Gila Bend
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Gila Bend.
Maricopa
Phoenix (Greyhound), Arizona
Phoenix (Airport), Arizona
Phoenix (Metro Center Transit Station), Arizona
Flight Path Map
This map shows the direct air route between San Luis and Mesa. Straight-line distance: 183.34 mi (295.06 km).
#1 San Luis
Town in Yuma County, Arizona, United States
| Population | 31,520 |
| Coordinates | 32.4870000, -114.7821800 |
| Altitude | 40 |
| Country | United States |
#2 Mesa
The fourth most populous city in Arizona and the center of the Mesa metropolitan area.
| Population | 528,159 |
| Coordinates | 33.4222700, -111.8226400 |
| Altitude | 378 |
| Country | United States |
End: East University Drive (-111.82264, 33.422353)
Estimated Travel Time
Distance: 363 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 30m |
| 40 mph (64.37 km/h) | 05h 37m |
| 50 mph (80.47 km/h) | 04h 30m |
| 60 mph (96.56 km/h) | 03h 45m |
| 70 mph (112.65 km/h) | 03h 13m |
| 80 mph (129 km/h) | 02h 48m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.95 | $39.36 | $78.72 |
| Mid-grade | $5.34 | $42.44 | $84.87 |
| Premium | $5.57 | $44.25 | $88.50 |
| Diesel | $6.37 | $50.61 | $101.22 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Arizona · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.