How far is Mesa, AZ from San Luis, AZ?
The driving distance from Mesa, AZ to San Luis, AZ is about 225.4 miles (362.7 km), with a travel time of about 04h 09m by car.
- The straight-line flight distance is about 183.4 miles (295.1 km).
- For a round trip, plan for roughly 08h 19m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM MST.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 09m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Maricopa County, Arizona, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Mesa and San Luis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mesa and San Luis.
-
1
Start on East University Drive
22 m · 9 sec · East University Drive
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2
Turn left onto North Mesa Drive
2619 ft · 56 sec · North Mesa Drive
-
3
Continue on South Mesa Drive
2 mi · 4 min · South Mesa Drive
-
4
Take the ramp right toward US 60 West: Phoenix
1746 ft · 45 sec
-
5
Merge slight left onto Superstition Freeway
7.5 mi · 9 min · Superstition Freeway
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6
Take the exit slight left toward I 10 East: Tucson
1.5 km · 2 min
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7
Keep slight left to continue on I 10 East: Tucson
2266 ft · 55 sec
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8
Merge slight left onto Maricopa Freeway
6.1 mi · 7 min · Maricopa Freeway
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9
Continue on Phoenix-Casa Grande Highway
2.2 mi · 3 min · Phoenix-Casa Grande Highway
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10
Take the exit slight right toward AZ 347 South
1889 ft · 49 sec
-
11
Turn right onto West Queen Creek Road
1.7 mi · 2 min · West Queen Creek Road
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12
Continue on North Maricopa Road
11.8 mi · 14 min · North Maricopa Road
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13
Continue on North John Wayne Parkway
14.8 mi · 19 min · North John Wayne Parkway
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14
At the end of the road, turn right onto Gila Bend–Casa Grande Highway
5.6 mi · 6 min · Gila Bend–Casa Grande Highway
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15
Take the exit slight right toward I 8 West: San Diego
2124 ft · 52 sec
-
16
Merge slight left onto Phoenix Bypass Route
31.6 mi · 32 min · Phoenix Bypass Route
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17
Continue on Blue Star Memorial Highway
111.9 mi · 1 hr 54 min · Blue Star Memorial Highway
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18
Take the exit slight right toward AZ 195: Araby Road, San Luis
1661 ft · 41 sec
-
19
Keep slight left to continue on AZ 195: Araby Road, San Luis
81 m · 8 sec
-
20
Enter the roundabout and take exit 3 toward South Araby Road
82 m · 4 sec · South Araby Road
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21
Exit the roundabout onto South Araby Road
723 ft · 9 sec · South Araby Road
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22
Enter the roundabout and take exit 2 toward Robert A. Vaughan Expressway
57 m · 3 sec · South Araby Road
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23
Exit the rotary onto South Araby Road
2417 ft · 33 sec · South Araby Road
-
24
Continue on Robert A. Vaughan Expressway
20.9 mi · 24 min · Robert A. Vaughan Expressway
-
25
Continue on East Cesar Chavez Boulevard
4.5 mi · 7 min · East Cesar Chavez Boulevard
-
26
Turn left onto 4th Avenue
2637 ft · 55 sec · 4th Avenue
-
27
At the end of the road, turn right onto Urtuzuastegui Street
1286 ft · 38 sec · Urtuzuastegui Street
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28
Arrive at your destination
0 m · 1 sec · Urtuzuastegui Street
Car Route Details
A richer read on the saved driving route between Mesa and San Luis.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Blue Star Memorial Highway
Continue on Blue Star Memorial Highway
112 mi · 01h 54m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Mesa and Sunny near San Luis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mesa to San Luis?
The road trip is about 225.4 miles (362.7 km) and usually takes 04h 09m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Gila Bend is a useful midpoint, sitting about 112.6 miles from Mesa and 112.8 miles from San Luis.
How much longer is the road route than the straight-line distance?
The direct path is about 183.4 miles (295.1 km), while the road route adds roughly 42 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM MST. If you want a more comfortable same-day return, try to leave by 8:40 AM MST.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $39.36 one way or $78.72 round trip. Estimated CO2 is about 70.7 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Mesa and Sunny near San Luis.
Stop Ideas Near Gila Bend
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Gila Bend.
Maricopa
Phoenix (Greyhound), Arizona
Phoenix (Airport), Arizona
Phoenix (Metro Center Transit Station), Arizona
Flight Path Map
This map shows the direct air route between Mesa and San Luis. Straight-line distance: 183.34 mi (295.06 km).
#1 Mesa
The fourth most populous city in Arizona and the center of the Mesa metropolitan area.
| Population | 528,159 |
| Coordinates | 33.4222700, -111.8226400 |
| Altitude | 378 |
| Country | United States |
#2 San Luis
Town in Yuma County, Arizona, United States
| Population | 31,520 |
| Coordinates | 32.4870000, -114.7821800 |
| Altitude | 40 |
| Country | United States |
End: San Luis (-114.78218, 32.487)
Estimated Travel Time
Distance: 363 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 30m |
| 40 mph (64.37 km/h) | 05h 38m |
| 50 mph (80.47 km/h) | 04h 30m |
| 60 mph (96.56 km/h) | 03h 45m |
| 70 mph (112.65 km/h) | 03h 13m |
| 80 mph (129 km/h) | 02h 48m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.95 | $39.36 | $78.72 |
| Mid-grade | $5.34 | $42.44 | $84.87 |
| Premium | $5.57 | $44.25 | $88.50 |
| Diesel | $6.37 | $50.61 | $101.22 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Arizona · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.