How far is Saint John, IN from Guilford, IN?
The driving distance from Saint John, IN to Guilford, IN is about 220.1 miles (354.2 km), with a travel time of about 04h 13m by car.
- The straight-line flight distance is about 156.3 miles (251.5 km).
- For a round trip, plan for roughly 08h 26m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 13m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Indiana, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Cloudy
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Saint John and Guilford.
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint John and Guilford.
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1
Start on St John Road
1.1 mi · 4 min · St John Road
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2
At the end of the road, turn left onto New Harmony Road
1.4 mi · 3 min · New Harmony Road
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3
Continue on East Boonville New Harmony Road
750 ft · 21 sec · East Boonville New Harmony Road
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4
Take the ramp right
1524 ft · 37 sec
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5
Merge slight left
5 mi · 5 min
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6
Take the exit slight right toward I 64 East: Louisville
3069 ft · 58 sec
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7
Merge slight left
91.7 mi · 1 hr 40 min
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8
Keep slight left to continue on I 265 East, SR 62 East
6.4 mi · 8 min
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9
Continue straight
7.4 mi · 9 min
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10
Continue on Gene Snyder Freeway
3.4 mi · 4 min · Gene Snyder Freeway
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11
Take the exit slight right toward I 71 North: Cincinnati
1556 ft · 38 sec
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12
Merge slight left
67.3 mi · 1 hr 12 min
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13
Keep slight left to continue on I 75 North, I 71 North: Cincinnati
12.1 mi · 14 min
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14
Take the exit slight right toward I 275
1620 ft · 32 sec
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15
Keep slight left to continue on I 275 West
1.2 km · 2 min
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16
Merge slight left onto Ronald Reagan Highway
13.3 mi · 15 min · Ronald Reagan Highway
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17
Continue on Cincinnati Bypass
1.4 mi · 2 min · Cincinnati Bypass
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18
Take the exit slight right toward US 50: Greendale, Lawrenceburg, Aurora
1.2 mi · 3 min
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19
Keep slight left
82 m · 9 sec
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20
Continue on Belleview Drive
1867 ft · 49 sec · Belleview Drive
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21
Turn right
5.2 mi · 9 min
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22
Turn left onto Main Street
1346 ft · 50 sec · Main Street
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23
Turn left
43 m · 6 sec
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24
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Saint John and Guilford.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 64 East
Merge slight left
91.7 mi · 01h 40m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Cloudy leaving Saint John and Chance Showers And Thunderstorms near Guilford.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Saint John to Guilford?
The road trip is about 220.1 miles (354.2 km) and usually takes 04h 13m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Utica is a useful midpoint, sitting about 109.9 miles from Saint John and 110.2 miles from Guilford.
How much longer is the road route than the straight-line distance?
The direct path is about 156.3 miles (251.5 km), while the road route adds roughly 63.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:34 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $29.30 one way or $58.60 round trip. Estimated CO2 is about 69.1 kg one way.
Do you cross a time zone on this route?
Yes. There is about a 1 hour time difference between Saint John and Guilford, so arrival and return times should be read in local time.
What should you check before leaving?
Before you leave, expect Partly Cloudy around Saint John and Chance Showers And Thunderstorms near Guilford.
Stop Ideas Near Utica
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Utica.
Louisville, Kentucky
Flight Path Map
This map shows the direct air route between Saint John and Guilford. Straight-line distance: 156.29 mi (251.53 km).
#1 Saint John
Town in Indiana, United States
| Population | 19,616 |
| Coordinates | 38.0792100, -87.4500100 |
| Altitude | 131 |
| Country | United States |
#2 Guilford
Unincorporated community in Indiana
| Population | 35,285 |
| Coordinates | 39.1681100, -84.9119000 |
| Altitude | 152 |
| Country | United States |
End: Guilford (-84.9119, 39.16811)
Estimated Travel Time
Distance: 354 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 19m |
| 40 mph (64.37 km/h) | 05h 30m |
| 50 mph (80.47 km/h) | 04h 24m |
| 60 mph (96.56 km/h) | 03h 40m |
| 70 mph (112.65 km/h) | 03h 08m |
| 80 mph (129 km/h) | 02h 44m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $29.30 | $58.60 |
| Mid-grade | $4.25 | $33.05 | $66.09 |
| Premium | $4.65 | $36.16 | $72.32 |
| Diesel | $5.30 | $41.21 | $82.42 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Indiana · Apr 15, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.