How far is Port Saint Lucie, FL from North Key Largo, FL?
The driving distance from Port Saint Lucie, FL to North Key Largo, FL is about 166 miles (267.2 km), with a travel time of about 03h 16m by car.
- The straight-line flight distance is about 140.1 miles (225.4 km).
- For a round trip, plan for roughly 06h 33m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 16m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Broward County, Florida
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Cloudy then Chance Showers And Thunderstorms
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Port Saint Lucie and North Key Largo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Port Saint Lucie and North Key Largo.
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1
Start on Southwest Carter Avenue
66 m · 11 sec · Southwest Carter Avenue
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2
Turn right onto Southeast Airoso Boulevard
1.6 mi · 3 min · Southeast Airoso Boulevard
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3
Turn right onto Southwest Port Saint Lucie Boulevard
1.3 km · 1 min · Southwest Port Saint Lucie Boulevard
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4
Turn left onto Southwest Bayshore Boulevard
560 ft · 22 sec · Southwest Bayshore Boulevard
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5
Take the ramp straight toward Florida's Turnpike Toll
2787 ft · 1 min
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6
Keep slight left to continue on Miami, Florida's Turnpike South
2780 ft · 1 min
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7
Merge slight left onto Florida's Turnpike
95.5 mi · 1 hr 46 min · Florida's Turnpike
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8
Take the exit slight right toward Florida's Turnpike Toll South, Homestead
1197 ft · 20 sec · Homestead Extension of Florida's Turnpike
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9
Keep slight left to continue on Homestead Extension of Florida's Turnpike
46.9 mi · 54 min · Homestead Extension of Florida's Turnpike
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10
Keep slight left
2930 ft · 1 min
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11
Merge slight left onto Dixie Highway
1 mi · 2 min · Dixie Highway
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12
Turn left onto Card Sound Road
16.5 mi · 23 min · Card Sound Road
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13
Turn right
1.7 mi · 3 min
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14
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Port Saint Lucie and North Key Largo.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Florida's Turnpike
Merge slight left onto Florida's Turnpike
95.5 mi · 01h 46m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Cloudy then Chance Showers And Thunderstorms leaving Port Saint Lucie and Chance Showers And Thunderstorms near North Key Largo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Port Saint Lucie to North Key Largo?
The road trip is about 166 miles (267.2 km) and usually takes 03h 16m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Palm Aire is a useful midpoint, sitting about 83.2 miles from Port Saint Lucie and 82.8 miles from North Key Largo.
How much longer is the road route than the straight-line distance?
The direct path is about 140.1 miles (225.4 km), while the road route adds roughly 25.9 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 10:26 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $24.31 one way or $48.61 round trip. Estimated CO2 is about 52.1 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Cloudy then Chance Showers And Thunderstorms around Port Saint Lucie and Chance Showers And Thunderstorms near North Key Largo.
Stop Ideas Near Palm Aire
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
City Hall Parking Garage
City Hall in the Mall
Lauderhill Towne Centre Library
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Palm Aire.
Fort Lauderdale
Deerfield Beach
Hollywood
Delray Beach
Flight Path Map
This map shows the direct air route between Port Saint Lucie and North Key Largo. Straight-line distance: 140.03 mi (225.36 km).
#1 Port Saint Lucie
The second most populous city in St.
| Population | 209,715 |
| Coordinates | 27.2939300, -80.3503300 |
| Altitude | 5 |
| Country | United States |
#2 North Key Largo
Census-designated place in Monroe County, Florida, United States
| Population | 1,244 |
| Coordinates | 25.2673400, -80.3233900 |
| Altitude | 0 |
| Country | United States |
End: North Key Largo (-80.32339, 25.26734)
Estimated Travel Time
Distance: 267 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 31m |
| 40 mph (64.37 km/h) | 04h 09m |
| 50 mph (80.47 km/h) | 03h 19m |
| 60 mph (96.56 km/h) | 02h 46m |
| 70 mph (112.65 km/h) | 02h 22m |
| 80 mph (129 km/h) | 02h 04m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $24.31 | $48.61 |
| Mid-grade | $4.60 | $26.93 | $53.87 |
| Premium | $4.90 | $28.69 | $57.38 |
| Diesel | $4.35 | $25.49 | $50.98 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 13, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.