How far is Port Saint Lucie, FL from Mayo, FL?
The driving distance from Port Saint Lucie, FL to Mayo, FL is about 286.6 miles (461.2 km), with a travel time of about 05h 24m by car.
- The straight-line flight distance is about 256.2 miles (412.3 km).
- For a round trip, plan for roughly 10h 49m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 24m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Lake County, Florida, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny then Slight Chance Showers And Thunderstorms
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Port Saint Lucie and Mayo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Port Saint Lucie and Mayo.
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1
Start on Southwest Carter Avenue
66 m · 11 sec · Southwest Carter Avenue
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2
Turn right onto Southeast Airoso Boulevard
1.6 mi · 3 min · Southeast Airoso Boulevard
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3
Turn right onto Southwest Port Saint Lucie Boulevard
1.3 km · 1 min · Southwest Port Saint Lucie Boulevard
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4
Turn left onto Southwest Bayshore Boulevard
560 ft · 22 sec · Southwest Bayshore Boulevard
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5
Take the ramp straight toward Florida's Turnpike Toll
2787 ft · 1 min
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6
Keep slight right to continue on Orlando, Florida's Turnpike North
1842 ft · 45 sec
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7
Merge slight left onto Florida's Turnpike
164.8 mi · 2 hr 57 min · Florida's Turnpike
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8
Keep slight left to continue on Florida's Turnpike
1281 ft · 16 sec · Florida's Turnpike
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9
Merge slight left
71.6 mi · 1 hr 17 min
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10
Take the exit slight right toward US 441: Alachua, High Springs
1040 ft · 59 sec
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11
Turn right onto ML King Memorial Highway
4 mi · 5 min · ML King Memorial Highway
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12
Continue on Santa Fe Boulevard
1.4 km · 1 min · Santa Fe Boulevard
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13
Turn slight left onto Northeast 1st Avenue
3020 ft · 1 min · Northeast 1st Avenue
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14
Continue on Northwest 1st Avenue
40.3 mi · 54 min · Northwest 1st Avenue
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15
Continue on Main Street
1.1 km · 1 min · Main Street
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16
Arrive at your destination
0 m · 1 sec · Main Street
Car Route Details
A richer read on the saved driving route between Port Saint Lucie and Mayo.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Florida's Turnpike
Merge slight left onto Florida's Turnpike
165 mi · 02h 57m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny then Slight Chance Showers And Thunderstorms leaving Port Saint Lucie and Chance Showers And Thunderstorms near Mayo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Port Saint Lucie to Mayo?
The road trip is about 286.6 miles (461.2 km) and usually takes 05h 24m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Ferndale is a useful midpoint, sitting about 143.5 miles from Port Saint Lucie and 143.2 miles from Mayo.
How much longer is the road route than the straight-line distance?
The direct path is about 256.2 miles (412.3 km), while the road route adds roughly 30.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 6:10 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $41.94 one way or $83.87 round trip. Estimated CO2 is about 89.8 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny then Slight Chance Showers And Thunderstorms around Port Saint Lucie and Chance Showers And Thunderstorms near Mayo.
Stop Ideas Near Ferndale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
City of Tavares - City Hall
Minneola City Hall
Tavares Utility Billing
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Ferndale.
Orlando Health/Amtrak
Winter Park
The Villages-Lady Lake, FL
Wildwood, Florida
Flight Path Map
This map shows the direct air route between Port Saint Lucie and Mayo. Straight-line distance: 256.22 mi (412.34 km).
#1 Port Saint Lucie
The second most populous city in St.
| Population | 209,715 |
| Coordinates | 27.2939300, -80.3503300 |
| Altitude | 5 |
| Country | United States |
#2 Mayo
Municipality in Lafayette, Florida, USA
| Population | 1,289 |
| Coordinates | 30.0530000, -83.1748600 |
| Altitude | 27 |
| Country | United States |
End: Mayo (-83.17486, 30.053)
Estimated Travel Time
Distance: 461 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 32m |
| 40 mph (64.37 km/h) | 07h 09m |
| 50 mph (80.47 km/h) | 05h 43m |
| 60 mph (96.56 km/h) | 04h 46m |
| 70 mph (112.65 km/h) | 04h 05m |
| 80 mph (129 km/h) | 03h 34m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $41.94 | $83.87 |
| Mid-grade | $4.60 | $46.47 | $92.93 |
| Premium | $4.90 | $49.50 | $99.00 |
| Diesel | $4.35 | $43.98 | $87.96 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 26, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.