How far is Port Saint Lucie, FL from Gainesville, FL?
The driving distance from Port Saint Lucie, FL to Gainesville, FL is about 227.4 miles (365.9 km), with a travel time of about 03h 22m by car.
- The straight-line flight distance is about 202.3 miles (325.5 km).
- For a round trip, plan for roughly 06h 45m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 22m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Orange County, Florida
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Partly Sunny then Slight Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Port Saint Lucie and Gainesville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Port Saint Lucie and Gainesville.
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1
Start on Southwest Carter Avenue
66 m · 11 sec · Southwest Carter Avenue
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2
Turn right onto Southeast Airoso Boulevard
1.6 mi · 3 min · Southeast Airoso Boulevard
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3
Turn right onto Southwest Port Saint Lucie Boulevard
1.3 km · 1 min · Southwest Port Saint Lucie Boulevard
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4
Turn left onto Southwest Bayshore Boulevard
560 ft · 22 sec · Southwest Bayshore Boulevard
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5
Take the ramp straight toward Florida's Turnpike Toll
2787 ft · 1 min
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6
Keep slight right to continue on Orlando, Florida's Turnpike North
1842 ft · 45 sec
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7
Merge slight left onto Florida's Turnpike
164.8 mi · 2 hr 57 min · Florida's Turnpike
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8
Keep slight left to continue on Florida's Turnpike
1281 ft · 16 sec · Florida's Turnpike
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9
Merge slight left
46.1 mi · 49 min
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10
Take the exit slight right toward CR 234: Micanopy
1213 ft · 32 sec
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11
Turn right onto Southeast County Road 234
1.3 mi · 2 min · Southeast County Road 234
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12
Turn left
128 m · 15 sec
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13
Turn straight
8 mi · 10 min
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14
Turn right onto Southwest Williston Road
2889 ft · 1 min · Southwest Williston Road
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15
Turn left onto South Main Street
1.6 mi · 3 min · South Main Street
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16
Enter the roundabout and take exit 2 toward South Main Street
28 m · 2 sec · South Main Street
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17
Exit the roundabout onto South Main Street
1317 ft · 32 sec · South Main Street
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18
Enter the roundabout and take exit 2 toward South Main Street
54 m · 4 sec · South Main Street
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19
Exit the roundabout onto South Main Street
2512 ft · 1 min · South Main Street
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20
Arrive at your destination
0 m · 1 sec · South Main Street
Car Route Details
A richer read on the saved driving route between Port Saint Lucie and Gainesville.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Florida's Turnpike
Merge slight left onto Florida's Turnpike
165 mi · 02h 57m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Port Saint Lucie and Partly Sunny then Slight Chance Showers And Thunderstorms near Gainesville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Port Saint Lucie to Gainesville?
The road trip is about 227.4 miles (365.9 km) and usually takes 03h 22m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Southchase is a useful midpoint, sitting about 113.7 miles from Port Saint Lucie and 113.6 miles from Gainesville.
How much longer is the road route than the straight-line distance?
The direct path is about 202.3 miles (325.5 km), while the road route adds roughly 25.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 10:14 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $33.27 one way or $66.53 round trip. Estimated CO2 is about 71.3 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Port Saint Lucie and Partly Sunny then Slight Chance Showers And Thunderstorms near Gainesville.
Stop Ideas Near Southchase
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Windermere Town Hall
City of Orlando
Celebration Town Hall
City Hall
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Southchase.
Kissimmee
Orlando Health/Amtrak
Winter Park
Sanford
Flight Path Map
This map shows the direct air route between Port Saint Lucie and Gainesville. Straight-line distance: 202.27 mi (325.53 km).
#1 Port Saint Lucie
The second most populous city in St.
| Population | 209,715 |
| Coordinates | 27.2939300, -80.3503300 |
| Altitude | 5 |
| Country | United States |
#2 Gainesville
The third most populous city in Florida.
| Population | 135,004 |
| Coordinates | 29.6516300, -82.3248300 |
| Altitude | 54 |
| Country | United States |
End: South Main Street (-82.32501, 29.65163)
Estimated Travel Time
Distance: 366 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 34m |
| 40 mph (64.37 km/h) | 05h 41m |
| 50 mph (80.47 km/h) | 04h 32m |
| 60 mph (96.56 km/h) | 03h 47m |
| 70 mph (112.65 km/h) | 03h 14m |
| 80 mph (129 km/h) | 02h 50m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $33.27 | $66.53 |
| Mid-grade | $4.60 | $36.86 | $73.72 |
| Premium | $4.90 | $39.27 | $78.53 |
| Diesel | $4.35 | $34.89 | $69.77 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 01, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.