How far is Port Saint Lucie, FL from Destin, FL?
The driving distance from Port Saint Lucie, FL to Destin, FL is about 529.8 miles (852.7 km), with a travel time of about 09h 48m by car.
- The straight-line flight distance is about 429.1 miles (690.5 km).
- For a round trip, plan for roughly 19h 37m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 09h 48m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
County seat of Columbia County, Florida, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Port Saint Lucie and Destin.
Turn-by-Turn Driving Directions
Step-by-step road directions between Port Saint Lucie and Destin.
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1
Start on Southwest Carter Avenue
66 m · 11 sec · Southwest Carter Avenue
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2
Turn right onto Southeast Airoso Boulevard
1.6 mi · 3 min · Southeast Airoso Boulevard
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3
Turn right onto Southwest Port Saint Lucie Boulevard
1.3 km · 1 min · Southwest Port Saint Lucie Boulevard
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4
Turn left onto Southwest Bayshore Boulevard
560 ft · 22 sec · Southwest Bayshore Boulevard
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5
Take the ramp straight toward Florida's Turnpike Toll
2787 ft · 1 min
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6
Keep slight right to continue on Orlando, Florida's Turnpike North
1842 ft · 45 sec
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7
Merge slight left onto Florida's Turnpike
164.8 mi · 2 hr 57 min · Florida's Turnpike
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8
Keep slight left to continue on Florida's Turnpike
1281 ft · 16 sec · Florida's Turnpike
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9
Merge slight left
106.9 mi · 1 hr 55 min
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10
Take the exit slight right toward I 10: Jacksonville, Tallahassee
820 ft · 16 sec
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11
Keep slight left to continue on I 10 West: Tallahassee
1569 ft · 30 sec
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12
Merge slight right
211.3 mi · 3 hr 46 min
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13
Take the exit slight right toward US 331: DeFuniak Springs, Freeport
1849 ft · 45 sec
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14
Turn straight onto US Highway 331 South
9.9 mi · 12 min · US Highway 331 South
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15
Turn right
4.4 mi · 7 min
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16
Turn right onto Main Street
1794 ft · 48 sec · Main Street
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17
Continue on State Highway 20 West
17 mi · 24 min · State Highway 20 West
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18
Take the ramp slight left
1868 ft · 47 sec
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19
Merge slight left onto Walter Francis Spence Parkway
5.9 mi · 9 min · Walter Francis Spence Parkway
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20
Turn right onto Emerald Coast Parkway
4.3 mi · 9 min · Emerald Coast Parkway
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21
Turn right onto Benning Drive
102 m · 14 sec · Benning Drive
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22
Turn left
79 m · 20 sec
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23
Turn right
27 m · 9 sec
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24
Turn right onto Mountain Drive
53 m · 5 sec · Mountain Drive
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25
Arrive at your destination
0 m · 1 sec · Mountain Drive
Car Route Details
A richer read on the saved driving route between Port Saint Lucie and Destin.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 10 West
Merge slight right
211 mi · 03h 46m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Port Saint Lucie and Mostly Sunny near Destin.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Port Saint Lucie to Destin?
The road trip is about 529.8 miles (852.7 km) and usually takes 09h 48m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Lake City is a useful midpoint, sitting about 265 miles from Port Saint Lucie and 264.9 miles from Destin.
How much longer is the road route than the straight-line distance?
The direct path is about 429.1 miles (690.5 km), while the road route adds roughly 100.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $77.57 one way or $155.14 round trip. Estimated CO2 is about 166.2 kg one way.
Do you cross a time zone on this route?
Yes. There is about a 1 hour time difference between Port Saint Lucie and Destin, so arrival and return times should be read in local time.
What should you check before leaving?
Before you leave, expect Sunny around Port Saint Lucie and Mostly Sunny near Destin.
Stop Ideas Near Lake City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Lake City.
Waldo, Florida
Gainesville, Florida
Jacksonville
Palatka
Flight Path Map
This map shows the direct air route between Port Saint Lucie and Destin. Straight-line distance: 429.08 mi (690.53 km).
#1 Port Saint Lucie
The second most populous city in St.
| Population | 209,715 |
| Coordinates | 27.2939300, -80.3503300 |
| Altitude | 5 |
| Country | United States |
#2 Destin
City in Florida
| Population | 14,284 |
| Coordinates | 30.3935300, -86.4957800 |
| Altitude | 7 |
| Country | United States |
End: Destin (-86.49578, 30.39353)
Estimated Travel Time
Distance: 853 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 17h 39m |
| 40 mph (64.37 km/h) | 13h 14m |
| 50 mph (80.47 km/h) | 10h 35m |
| 60 mph (96.56 km/h) | 08h 49m |
| 70 mph (112.65 km/h) | 07h 34m |
| 80 mph (129 km/h) | 06h 36m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $77.57 | $155.14 |
| Mid-grade | $4.60 | $85.95 | $171.89 |
| Premium | $4.90 | $91.56 | $183.11 |
| Diesel | $4.35 | $81.34 | $162.69 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.