How far is Panama City, FL from Port Saint Lucie, FL?
The driving distance from Panama City, FL to Port Saint Lucie, FL is about 473 miles (761.3 km), with a travel time of about 07h 06m by car.
- The straight-line flight distance is about 377.7 miles (607.8 km).
- For a round trip, plan for roughly 14h 12m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 07h 06m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Alachua County, Florida, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Panama City and Port Saint Lucie.
Turn-by-Turn Driving Directions
Step-by-step road directions between Panama City and Port Saint Lucie.
-
1
Start on Luverne Avenue
131 m · 26 sec · Luverne Avenue
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2
Turn left onto East 7th Street
69 m · 14 sec · East 7th Street
-
3
Turn right onto Harrison Avenue
1 mi · 3 min · Harrison Avenue
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4
Continue straight
1.6 mi · 3 min
-
5
Continue straight
1.3 mi · 2 min
-
6
Continue straight
21.2 mi · 27 min
-
7
Turn right
28.4 mi · 39 min
-
8
Turn left
18.1 mi · 24 min
-
9
Turn right onto Selman Street
3018 ft · 1 min · Selman Street
-
10
Continue on Greensboro Highway
2.2 mi · 3 min · Greensboro Highway
-
11
Take the ramp slight right toward I 10 East: Tallahassee
2453 ft · 1 min
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12
Merge slight left
121.5 mi · 2 hr 10 min
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13
Take the exit slight right toward I-75 South: Tampa
1959 ft · 37 sec
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14
Merge slight left
107.2 mi · 1 hr 55 min
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15
Take the exit slight left toward Florida's Turnpike South, Orlando
165.2 mi · 2 hr 57 min · Florida's Turnpike
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16
Take the exit slight right toward Port Saint Lucie
1 mi · 3 min
-
17
Continue on Southwest Bayshore Boulevard
147 m · 15 sec · Southwest Bayshore Boulevard
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18
Turn right onto Southwest Port Saint Lucie Boulevard
1.4 km · 2 min · Southwest Port Saint Lucie Boulevard
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19
Turn left onto Southeast Airoso Boulevard
1.6 mi · 3 min · Southeast Airoso Boulevard
-
20
Turn left onto Southwest Carter Avenue
66 m · 9 sec · Southwest Carter Avenue
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21
Arrive at your destination
0 m · 1 sec · Southwest Carter Avenue
Car Route Details
A richer read on the saved driving route between Panama City and Port Saint Lucie.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Florida's Turnpike
Take the exit slight left toward Florida's Turnpike South, Orlando
165 mi · 02h 57m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Panama City and Sunny near Port Saint Lucie.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Panama City to Port Saint Lucie?
The road trip is about 473 miles (761.3 km) and usually takes 07h 06m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Alachua is a useful midpoint, sitting about 236.4 miles from Panama City and 236.6 miles from Port Saint Lucie.
How much longer is the road route than the straight-line distance?
The direct path is about 377.7 miles (607.8 km), while the road route adds roughly 95.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $69.23 one way or $138.46 round trip. Estimated CO2 is about 148.3 kg one way.
Do you cross a time zone on this route?
Yes. There is about a 1 hour time difference between Panama City and Port Saint Lucie, so arrival and return times should be read in local time.
What should you check before leaving?
Before you leave, expect Sunny around Panama City and Sunny near Port Saint Lucie.
Stop Ideas Near Alachua
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Alachua.
Gainesville, Florida
Waldo, Florida
Ocala, Florida
Palatka
Flight Path Map
This map shows the direct air route between Panama City and Port Saint Lucie. Straight-line distance: 377.67 mi (607.8 km).
#1 Panama City
County seat of Bay County, Florida, United States
| Population | 34,667 |
| Coordinates | 30.1594600, -85.6598300 |
| Altitude | 8 |
| Country | United States |
#2 Port Saint Lucie
The second most populous city in St.
| Population | 209,715 |
| Coordinates | 27.2939300, -80.3503300 |
| Altitude | 5 |
| Country | United States |
End: Southwest Carter Avenue (-80.350328, 27.294381)
Estimated Travel Time
Distance: 761 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 15h 45m |
| 40 mph (64.37 km/h) | 11h 49m |
| 50 mph (80.47 km/h) | 09h 27m |
| 60 mph (96.56 km/h) | 07h 53m |
| 70 mph (112.65 km/h) | 06h 45m |
| 80 mph (129 km/h) | 05h 54m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $69.23 | $138.46 |
| Mid-grade | $4.60 | $76.71 | $153.41 |
| Premium | $4.90 | $81.71 | $163.43 |
| Diesel | $4.35 | $72.60 | $145.20 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 17, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.