How far is O'Fallon, MO from Doniphan, MO?
The driving distance from O'Fallon, MO to Doniphan, MO is about 199.8 miles (321.6 km), with a travel time of about 04h 00m by car.
- The straight-line flight distance is about 151.4 miles (243.7 km).
- For a round trip, plan for roughly 08h 01m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 00m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between O'Fallon and Doniphan.
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon and Doniphan.
-
1
Start on the route
8 m · 7 sec
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2
Turn left onto South Main Street
3116 ft · 2 min · South Main Street
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3
Turn left onto Drennen Parkway
1.4 km · 1 min · Drennen Parkway
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4
Take the ramp slight left toward I 70 East: Saint Louis
133 m · 6 sec
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5
Merge slight left
13.5 mi · 17 min
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6
Take the exit slight right toward I 270: Chicago, Memphis
872 ft · 12 sec
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7
Keep slight right to continue on I 270 South: Memphis
2339 ft · 33 sec
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8
Continue on I 270 South: Memphis
723 ft · 10 sec
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9
Merge slight left
19 mi · 24 min
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10
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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11
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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12
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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13
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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14
Continue on Police Officer Steven Jarvis Memorial Highway
18.3 mi · 20 min · Police Officer Steven Jarvis Memorial Highway
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15
Take the exit slight right toward US 67 South: Farmington, Poplar Bluff
914 ft · 20 sec
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16
Keep slight left
729 ft · 18 sec
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17
Enter the roundabout and take exit 1 toward the route
9 m · 1 sec
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18
Exit the roundabout
112.6 mi · 2 hr 10 min
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19
Take the exit slight right toward US 67 South: Corning, Arkansas
10.4 mi · 12 min
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20
Take the exit slight right
1651 ft · 45 sec
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21
Continue straight
18.2 mi · 27 min
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22
Turn left onto Walnut Street
1.1 km · 1 min · Walnut Street
-
23
Turn left onto Plum Street
52 m · 7 sec · Plum Street
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24
Arrive at your destination
0 m · 1 sec · Plum Street
Car Route Details
A richer read on the saved driving route between O'Fallon and Doniphan.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
US 67 South
Exit the roundabout
113 mi · 02h 10m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms leaving O'Fallon and Chance Showers And Thunderstorms near Doniphan.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from O'Fallon to Doniphan?
The road trip is about 199.8 miles (321.6 km) and usually takes 04h 00m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Farmington is a useful midpoint, sitting about 100 miles from O'Fallon and 99.9 miles from Doniphan.
How much longer is the road route than the straight-line distance?
The direct path is about 151.4 miles (243.7 km), while the road route adds roughly 48.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:58 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $26.59 one way or $53.17 round trip. Estimated CO2 is about 62.7 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around O'Fallon and Chance Showers And Thunderstorms near Doniphan.
Stop Ideas Near Farmington
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Farmington.
Kirkwood
Gateway Transportation Center
Washington
Carbondale station
Flight Path Map
This map shows the direct air route between O'Fallon and Doniphan. Straight-line distance: 151.45 mi (243.73 km).
#1 O'Fallon
The most populous city in St.
| Population | 89,769 |
| Coordinates | 38.8106100, -90.6998500 |
| Altitude | 165 |
| Country | United States |
#2 Doniphan
City in Ripley County, Missouri, United States
| Population | 1,919 |
| Coordinates | 36.6208900, -90.8234600 |
| Altitude | 122 |
| Country | United States |
End: Doniphan (-90.82346, 36.62089)
Estimated Travel Time
Distance: 322 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 39m |
| 40 mph (64.37 km/h) | 04h 59m |
| 50 mph (80.47 km/h) | 03h 59m |
| 60 mph (96.56 km/h) | 03h 19m |
| 70 mph (112.65 km/h) | 02h 51m |
| 80 mph (129 km/h) | 02h 29m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $26.59 | $53.17 |
| Mid-grade | $4.25 | $29.98 | $59.97 |
| Premium | $4.65 | $32.81 | $65.62 |
| Diesel | $5.30 | $37.39 | $74.79 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 18, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.