How far is Odessa, TX from San Antonio, TX?
The driving distance from Odessa, TX to San Antonio, TX is about 341.6 miles (549.8 km), with a travel time of about 05h 13m by car.
- The straight-line flight distance is about 284.7 miles (458.1 km).
- For a round trip, plan for roughly 10h 26m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 13m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny
Partly Sunny
Driving Route Map
The map below follows the saved road route between Odessa and San Antonio.
Turn-by-Turn Driving Directions
Step-by-step road directions between Odessa and San Antonio.
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1
Start on North Grant Avenue
4 m · 7 sec · North Grant Avenue
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2
Continue on North Grant Avenue
3.1 mi · 5 min · North Grant Avenue
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3
Continue on South US Highway 385
51.3 mi · 59 min · South US Highway 385
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4
Continue on Farm to Market Road 305
18.1 mi · 27 min · Farm to Market Road 305
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5
At the end of the road, turn right
4.2 mi · 6 min
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6
At the end of the road, turn left onto I 10 Service Road
126 m · 8 sec · I 10 Service Road
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7
Take the ramp straight toward I 10 East: San Antonio
1786 ft · 44 sec
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8
Merge slight left
242.5 mi · 3 hr 51 min
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9
Keep slight right
17.4 mi · 20 min
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10
Keep slight right to continue on McDermott Freeway
1.7 mi · 2 min · McDermott Freeway
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11
Take the exit slight right toward Santa Rosa Street, Downtown
2505 ft · 1 min
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12
Turn straight onto North Pecos-La Trinidad
804 ft · 16 sec · North Pecos-La Trinidad
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13
Keep slight right to continue on North Pecos-La Trinidad
2963 ft · 1 min · North Pecos-La Trinidad
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14
Turn left onto Dolorosa Street
2582 ft · 56 sec · Dolorosa Street
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15
Arrive at your destination
0 m · 1 sec · Dolorosa Street
Car Route Details
A richer read on the saved driving route between Odessa and San Antonio.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 10 East
Merge slight left
243 mi · 03h 51m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Sunny leaving Odessa and Partly Sunny near San Antonio.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Odessa to San Antonio?
The road trip is about 341.6 miles (549.8 km) and usually takes 05h 13m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Sonora is a useful midpoint, sitting about 170.2 miles from Odessa and 171.4 miles from San Antonio.
How much longer is the road route than the straight-line distance?
The direct path is about 284.7 miles (458.1 km), while the road route adds roughly 56.9 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:34 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $45.54 one way or $91.07 round trip. Estimated CO2 is about 107.1 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny around Odessa and Partly Sunny near San Antonio.
Flight Path Map
This map shows the direct air route between Odessa and San Antonio. Straight-line distance: 284.63 mi (458.07 km).
#1 Odessa
The second most populous city in Ector County, Texas.
| Population | 125,413 |
| Coordinates | 31.8456800, -102.3676400 |
| Altitude | 884 |
| Country | United States |
#2 San Antonio
The seventh most populous city in the United States and the center of the San Antonio metropolitan area.
| Population | 1,567,118 |
| Coordinates | 29.4241200, -98.4936300 |
| Altitude | 198 |
| Country | United States |
End: Dolorosa Street (-98.493645, 29.424163)
Estimated Travel Time
Distance: 550 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 22m |
| 40 mph (64.37 km/h) | 08h 32m |
| 50 mph (80.47 km/h) | 06h 49m |
| 60 mph (96.56 km/h) | 05h 41m |
| 70 mph (112.65 km/h) | 04h 52m |
| 80 mph (129 km/h) | 04h 15m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.78 | $45.54 | $91.07 |
| Mid-grade | $4.25 | $51.24 | $102.47 |
| Premium | $4.59 | $55.32 | $110.64 |
| Diesel | $3.99 | $48.12 | $96.23 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · May 30, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.