How far is Natchez, MS from Tupelo, MS?
The driving distance from Natchez, MS to Tupelo, MS is about 284 miles (457 km), with a travel time of about 04h 56m by car.
- The straight-line flight distance is about 243.4 miles (391.7 km).
- For a round trip, plan for roughly 09h 53m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 56m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Leake County, Mississippi, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms Likely then Chance Showers And Thunderstorms
Rain Showers Likely
Driving Route Map
The map below follows the saved road route between Natchez and Tupelo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Natchez and Tupelo.
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1
Start on South Pearl Street
118 m · 21 sec · South Pearl Street
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2
Turn right onto Franklin Street
1.1 mi · 2 min · Franklin Street
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3
Turn slight left onto Devereaux Drive
1.1 mi · 2 min · Devereaux Drive
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4
Take the ramp straight toward Devereaux Drive
714 ft · 20 sec · Devereaux Drive
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5
Merge slight right
3.3 mi · 4 min
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6
Take the exit slight right
53.2 mi · 1 hr 2 min
-
7
Take the exit slight left
1129 ft · 28 sec
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8
Merge slight left
53.2 mi · 57 min
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9
Keep slight right
2.1 mi · 3 min
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10
Keep slight left to continue on Grenada, Memphis
4.2 mi · 5 min
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11
Take the exit slight right toward MS 25 North: Carthage
1131 ft · 28 sec
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12
Turn right onto Lakeland Drive
12.3 mi · 15 min · Lakeland Drive
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13
Continue on MS Hwy 25
79.6 mi · 1 hr 30 min · MS Hwy 25
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14
Take the exit straight
24.9 mi · 29 min
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15
Keep slight right
2.4 mi · 3 min
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16
Continue straight
3.8 mi · 4 min
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17
Keep slight right to continue on US 82 East, MS 25 North: Columbus, West Point
12.3 mi · 14 min
-
18
Take the exit slight right toward US 45 Alternate North, MS 25 North: West Point, Tupelo
1370 ft · 34 sec
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19
Merge slight left onto US Highway 45 Alternate
34.6 mi · 43 min · US Highway 45 Alternate
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20
Continue on Martin Luther King Drive
18.1 mi · 21 min · Martin Luther King Drive
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21
Continue on Martin Luther King, Junior Drive
1.5 mi · 2 min · Martin Luther King, Junior Drive
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22
Take the exit slight right toward MS 6 East: Downtown Tupelo
2008 ft · 49 sec
-
23
Keep slight left
52 m · 7 sec
-
24
Turn left onto East Main Street
1.1 km · 2 min · East Main Street
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25
Turn right onto North Spring Street
70 m · 10 sec · North Spring Street
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26
Arrive at your destination
0 m · 1 sec · North Spring Street
Car Route Details
A richer read on the saved driving route between Natchez and Tupelo.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
MS Hwy 25
Continue on MS Hwy 25
79.6 mi · 01h 30m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms Likely then Chance Showers And Thunderstorms leaving Natchez and Rain Showers Likely near Tupelo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Natchez to Tupelo?
The road trip is about 284 miles (457 km) and usually takes 04h 56m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Lena is a useful midpoint, sitting about 155 miles from Natchez and 129 miles from Tupelo.
How much longer is the road route than the straight-line distance?
The direct path is about 243.4 miles (391.7 km), while the road route adds roughly 40.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 7:06 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $37.95 one way or $75.89 round trip. Estimated CO2 is about 89 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms Likely then Chance Showers And Thunderstorms around Natchez and Rain Showers Likely near Tupelo.
Stop Ideas Near Lena
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Lena.
Union Station
Yazoo City
Union Station
Hazlehurst station
Flight Path Map
This map shows the direct air route between Natchez and Tupelo. Straight-line distance: 243.39 mi (391.7 km).
#1 Natchez
County seat of Adams County, Mississippi, United States
| Population | 14,362 |
| Coordinates | 31.5601700, -91.4032900 |
| Altitude | 66 |
| Country | United States |
#2 Tupelo
City in and county seat of Lee County, Mississippi, United States
| Population | 38,303 |
| Coordinates | 34.2580700, -88.7046400 |
| Altitude | 85 |
| Country | United States |
End: North Spring Street (-88.704455, 34.258074)
Estimated Travel Time
Distance: 457 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 27m |
| 40 mph (64.37 km/h) | 07h 06m |
| 50 mph (80.47 km/h) | 05h 40m |
| 60 mph (96.56 km/h) | 04h 43m |
| 70 mph (112.65 km/h) | 04h 03m |
| 80 mph (129 km/h) | 03h 32m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $37.95 | $75.89 |
| Mid-grade | $4.26 | $42.68 | $85.35 |
| Premium | $4.63 | $46.34 | $92.69 |
| Diesel | $5.42 | $54.26 | $108.52 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · May 24, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.