How far is Natchez, MS from Biloxi, MS?
The driving distance from Natchez, MS to Biloxi, MS is about 206.7 miles (332.7 km), with a travel time of about 03h 39m by car.
- The straight-line flight distance is about 169.4 miles (272.7 km).
- For a round trip, plan for roughly 07h 18m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 39m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Pike County, Mississippi, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms Likely then Chance Showers And Thunderstorms
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Natchez and Biloxi.
Turn-by-Turn Driving Directions
Step-by-step road directions between Natchez and Biloxi.
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1
Start on South Pearl Street
118 m · 21 sec · South Pearl Street
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2
Turn right onto Franklin Street
1.1 mi · 2 min · Franklin Street
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3
Turn slight left onto Devereaux Drive
1.1 mi · 2 min · Devereaux Drive
-
4
Take the ramp straight toward Devereaux Drive
714 ft · 20 sec · Devereaux Drive
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5
Merge slight right
3.3 mi · 4 min
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6
Take the exit slight right
28.3 mi · 33 min
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7
Take the exit slight right
1435 ft · 39 sec
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8
Keep slight left
51 m · 5 sec
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9
Turn right
3187 ft · 44 sec
-
10
Turn right
28.9 mi · 33 min
-
11
Take the exit slight right
13.6 mi · 15 min
-
12
Continue straight
43.2 mi · 46 min
-
13
Take the exit slight right toward I 12 East: Slidell
1124 ft · 28 sec
-
14
Merge slight left onto West Florida Republic Parkway
47.5 mi · 51 min · West Florida Republic Parkway
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15
Continue on West Florida Republic Parkway
1.1 km · 44 sec · West Florida Republic Parkway
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16
Merge slight left onto Stephen E Ambrose Memorial Parkway
51.2 mi · 55 min · Stephen E Ambrose Memorial Parkway
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17
Take the exit slight right toward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
605 ft · 15 sec
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18
Keep slight left
2126 ft · 52 sec
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19
Keep slight right to continue on I 110: Biloxi, Keesler Air Force Base
2830 ft · 1 min
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20
Merge slight left
2.7 mi · 4 min
-
21
Take the exit slight right toward Division Street
1852 ft · 47 sec
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22
Turn left onto Division Street
3090 ft · 2 min · Division Street
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23
Turn right onto Main Street
2572 ft · 1 min · Main Street
-
24
Turn left onto Howard Avenue
28 m · 3 sec · Howard Avenue
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25
Arrive at your destination
0 m · 1 sec · Howard Avenue
Car Route Details
A richer read on the saved driving route between Natchez and Biloxi.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Stephen E Ambrose Memorial Parkway
Merge slight left onto Stephen E Ambrose Memorial Parkway
51.2 mi · 00h 55m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms Likely then Chance Showers And Thunderstorms leaving Natchez and Showers And Thunderstorms near Biloxi.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Natchez to Biloxi?
The road trip is about 206.7 miles (332.7 km) and usually takes 03h 39m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Osyka is a useful midpoint, sitting about 112.7 miles from Natchez and 94 miles from Biloxi.
How much longer is the road route than the straight-line distance?
The direct path is about 169.4 miles (272.7 km), while the road route adds roughly 37.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 9:42 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $27.65 one way or $55.29 round trip. Estimated CO2 is about 64.9 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms Likely then Chance Showers And Thunderstorms around Natchez and Showers And Thunderstorms near Biloxi.
Stop Ideas Near Osyka
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Osyka.
McComb
Hammond
Brookhaven
Baton Rouge, Louisiana
Flight Path Map
This map shows the direct air route between Natchez and Biloxi. Straight-line distance: 169.46 mi (272.72 km).
#1 Natchez
County seat of Adams County, Mississippi, United States
| Population | 14,362 |
| Coordinates | 31.5601700, -91.4032900 |
| Altitude | 66 |
| Country | United States |
#2 Biloxi
The most populous city in Harrison County, Mississippi.
| Population | 46,127 |
| Coordinates | 30.3960300, -88.8853100 |
| Altitude | 6 |
| Country | United States |
End: Howard Avenue (-88.885301, 30.396075)
Estimated Travel Time
Distance: 333 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 53m |
| 40 mph (64.37 km/h) | 05h 10m |
| 50 mph (80.47 km/h) | 04h 08m |
| 60 mph (96.56 km/h) | 03h 26m |
| 70 mph (112.65 km/h) | 02h 57m |
| 80 mph (129 km/h) | 02h 34m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $27.65 | $55.29 |
| Mid-grade | $4.26 | $31.09 | $62.18 |
| Premium | $4.63 | $33.76 | $67.52 |
| Diesel | $5.42 | $39.53 | $79.06 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · May 24, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.