How far is Murrells Inlet, SC from Spartanburg, SC?
The driving distance from Murrells Inlet, SC to Spartanburg, SC is about 252.5 miles (406.4 km), with a travel time of about 04h 16m by car.
- The straight-line flight distance is about 191.3 miles (307.8 km).
- For a round trip, plan for roughly 08h 33m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 16m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Sumter County, South Carolina
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Rain Showers
Driving Route Map
The map below follows the saved road route between Murrells Inlet and Spartanburg.
Turn-by-Turn Driving Directions
Step-by-step road directions between Murrells Inlet and Spartanburg.
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1
Start on US 17 Business
1660 ft · 59 sec · US 17 Business
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2
Turn right onto Wachesaw Road
1253 ft · 36 sec · Wachesaw Road
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3
Turn left onto Highway 17
1.8 mi · 2 min · Highway 17
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4
Continue on Ocean Highway
17.4 mi · 25 min · Ocean Highway
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5
Continue on L. H. Siau Bridge
1340 ft · 25 sec · L. H. Siau Bridge
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6
Continue on Church Street
1.5 mi · 3 min · Church Street
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7
Merge slight left onto Highmarket Street
9.4 mi · 13 min · Highmarket Street
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8
Continue on Georgetown Highway
6.2 mi · 7 min · Georgetown Highway
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9
Continue on Georgetown Highway
1.7 mi · 2 min · Georgetown Highway
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10
Continue on East Main Street
1.7 mi · 3 min · East Main Street
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11
Continue on US Highway 521
26.8 mi · 30 min · US Highway 521
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12
Continue on Society Street
1.2 km · 54 sec · Society Street
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13
Continue on Society Street
2787 ft · 36 sec · Society Street
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14
Continue on C E Murray Boulevard
11.5 mi · 13 min · C E Murray Boulevard
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15
Turn slight right
103 m · 4 sec
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16
Keep slight left
984 ft · 15 sec
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17
Merge slight left onto Greeleyville Highway
2.4 mi · 3 min · Greeleyville Highway
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18
Continue on East Boyce Street
2023 ft · 58 sec · East Boyce Street
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19
Turn right onto North Church Street
1.1 km · 49 sec · North Church Street
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20
Continue on North Brooks Street
15.1 mi · 17 min · North Brooks Street
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21
Turn left onto South Guignard Parkway
1.1 mi · 1 min · South Guignard Parkway
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22
Continue on South Guignard Drive
3.6 mi · 4 min · South Guignard Drive
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23
Continue on Bultman Drive
1.1 km · 2 min · Bultman Drive
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24
Turn left onto Broad Street
3.3 mi · 6 min · Broad Street
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25
Continue straight
34.2 mi · 42 min
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26
Continue on Devine Street
1.1 mi · 2 min · Devine Street
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27
Turn slight right onto Millwood Avenue
1.8 mi · 4 min · Millwood Avenue
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28
Turn left onto Taylor Street
1.5 km · 2 min · Taylor Street
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29
Turn right onto Bull Street
2589 ft · 1 min · Bull Street
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30
Turn left onto Elmwood Avenue
1.5 km · 2 min · Elmwood Avenue
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31
Continue straight
3.8 mi · 5 min
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32
Merge slight left
55.7 mi · 1 hr 1 min
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33
Keep slight right to continue on Spartanburg
23.5 mi · 25 min
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34
Take the exit slight right toward US 221: Spartanburg-South, Moore
1360 ft · 33 sec
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35
Turn straight onto Highway 221
2.3 mi · 4 min · Highway 221
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36
Continue on South Church Street
6 mi · 11 min · South Church Street
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37
Arrive at your destination
0 m · 1 sec · North Church Street
Car Route Details
A richer read on the saved driving route between Murrells Inlet and Spartanburg.
Straightforward drive
The saved road route has a manageable number of maneuvers and should be easy to follow with normal attention to signs.
Elmwood Avenue
Merge slight left
55.7 mi · 01h 01m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms leaving Murrells Inlet and Rain Showers near Spartanburg.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Murrells Inlet to Spartanburg?
The road trip is about 252.5 miles (406.4 km) and usually takes 04h 16m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Stateburg is a useful midpoint, sitting about 119.3 miles from Murrells Inlet and 133.3 miles from Spartanburg.
How much longer is the road route than the straight-line distance?
The direct path is about 191.3 miles (307.8 km), while the road route adds roughly 61.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 8:26 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $35.29 one way or $70.59 round trip. Estimated CO2 is about 79.2 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around Murrells Inlet and Rain Showers near Spartanburg.
Stop Ideas Near Stateburg
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Stateburg.
Camden
Columbia
Kingstree
Florence
Flight Path Map
This map shows the direct air route between Murrells Inlet and Spartanburg. Straight-line distance: 191.28 mi (307.83 km).
#1 Murrells Inlet
Town in Georgetown County and Horry County, South Carolina, United States
| Population | 7,547 |
| Coordinates | 33.5510000, -79.0414300 |
| Altitude | 1 |
| Country | United States |
#2 Spartanburg
County seat of Spartanburg County, South Carolina, United States
| Population | 37,317 |
| Coordinates | 34.9495700, -81.9320500 |
| Altitude | 246 |
| Country | United States |
End: North Church Street (-81.931721, 34.94966)
Estimated Travel Time
Distance: 406 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 08h 24m |
| 40 mph (64.37 km/h) | 06h 18m |
| 50 mph (80.47 km/h) | 05h 03m |
| 60 mph (96.56 km/h) | 04h 12m |
| 70 mph (112.65 km/h) | 03h 36m |
| 80 mph (129 km/h) | 03h 09m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.96 | $35.29 | $70.59 |
| Mid-grade | $4.43 | $39.46 | $78.92 |
| Premium | $4.78 | $42.57 | $85.14 |
| Diesel | $5.62 | $50.11 | $100.22 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in South Carolina · May 02, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.