How far is Mound City, MO from St. Louis, MO?
The driving distance from Mound City, MO to St. Louis, MO is about 340.9 miles (548.7 km), with a travel time of about 05h 17m by car.
- The straight-line flight distance is about 288.2 miles (463.8 km).
- For a round trip, plan for roughly 10h 35m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 17m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Saline County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Slight Chance Showers And Thunderstorms then Chance Showers And Thunderstorms
Isolated Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Mound City and St. Louis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mound City and St. Louis.
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1
Start on the route
30 m · 9 sec
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2
Turn right onto State Street
1294 ft · 49 sec · State Street
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3
Turn left
1383 ft · 33 sec
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4
Take the ramp left toward I 29 South: Saint Joseph
891 ft · 22 sec
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5
Merge slight left
67.2 mi · 1 hr 12 min
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6
Merge slight right
2.2 mi · 2 min
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7
Keep slight right to continue on I 435 East: Saint Louis
28 mi · 31 min
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8
Keep slight right to continue on I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
1500 ft · 23 sec
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9
Keep slight left to continue on I 70 East: Saint Louis
1.2 mi · 2 min
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10
Keep slight left to continue on I 70 East: Saint Louis
143 m · 12 sec
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11
Merge slight left onto George Brett Super Highway
2213 ft · 29 sec · George Brett Super Highway
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12
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
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13
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
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14
Continue on Truman/Eisenhower Presidential Highway
2.6 mi · 3 min · Truman/Eisenhower Presidential Highway
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15
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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16
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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17
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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18
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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19
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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20
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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21
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
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22
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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23
Merge slight left onto Avenue of the Saints
27.7 mi · 34 min · Avenue of the Saints
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24
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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25
Continue on Jack Buck Memorial Highway
5.8 mi · 7 min · Jack Buck Memorial Highway
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26
Take the exit slight right toward 14th Street
1115 ft · 34 sec
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27
Turn left onto South 14th Street
1715 ft · 42 sec · South 14th Street
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28
Turn right onto Market Street
956 ft · 25 sec · Market Street
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29
Arrive at your destination
0 m · 1 sec · Market Street
Car Route Details
A richer read on the saved driving route between Mound City and St. Louis.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Dwight D. Eisenhower Highway
Continue on Dwight D. Eisenhower Highway
81 mi · 01h 35m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Slight Chance Showers And Thunderstorms then Chance Showers And Thunderstorms leaving Mound City and Isolated Showers And Thunderstorms near St. Louis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mound City to St. Louis?
The road trip is about 340.9 miles (548.7 km) and usually takes 05h 17m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Nelson is a useful midpoint, sitting about 170.2 miles from Mound City and 170.8 miles from St. Louis.
How much longer is the road route than the straight-line distance?
The direct path is about 288.2 miles (463.8 km), while the road route adds roughly 52.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:24 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $45.37 one way or $90.73 round trip. Estimated CO2 is about 106.9 kg one way.
What should you check before leaving?
Before you leave, expect Slight Chance Showers And Thunderstorms then Chance Showers And Thunderstorms around Mound City and Isolated Showers And Thunderstorms near St. Louis.
Stop Ideas Near Nelson
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Nelson.
Sedalia
Warrensburg
Jefferson City
Lee's Summit
Flight Path Map
This map shows the direct air route between Mound City and St. Louis. Straight-line distance: 288.16 mi (463.75 km).
#1 Mound City
City in Missouri
| Population | 1,039 |
| Coordinates | 40.1311100, -95.2316400 |
| Altitude | 271 |
| Country | United States |
#2 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
End: Market Street (-90.197859, 38.627348)
Estimated Travel Time
Distance: 549 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 21m |
| 40 mph (64.37 km/h) | 08h 31m |
| 50 mph (80.47 km/h) | 06h 49m |
| 60 mph (96.56 km/h) | 05h 40m |
| 70 mph (112.65 km/h) | 04h 52m |
| 80 mph (129 km/h) | 04h 15m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $45.37 | $90.73 |
| Mid-grade | $4.25 | $51.16 | $102.33 |
| Premium | $4.65 | $55.99 | $111.98 |
| Diesel | $5.30 | $63.81 | $127.61 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 16, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.