How far is Mesa, AZ from San Luis, AZ?
The driving distance from Mesa, AZ to San Luis, AZ is about 90.2 miles (145.2 km), with a travel time of about 02h 06m by car.
- The straight-line flight distance is about 75.4 miles (121.3 km).
- For a round trip, plan for roughly 04h 12m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM MST.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 06m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census designated place
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Mesa and San Luis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mesa and San Luis.
-
1
Start on East University Drive
1.6 km · 2 min · East University Drive
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2
Turn left onto North Country Club Drive
4 mi · 7 min · North Country Club Drive
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3
Continue on North Arizona Avenue
11 mi · 19 min · North Arizona Avenue
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4
Continue straight
6.1 mi · 9 min
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5
Take the ramp left toward I 10 East: Tucson
1507 ft · 37 sec
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6
Merge slight left onto Phoenix-Casa Grande Highway
22.5 mi · 23 min · Phoenix-Casa Grande Highway
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7
Take the exit slight right toward I 8 West: San Diego
3006 ft · 1 min
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8
Merge slight left onto Phoenix Bypass Route
3 mi · 3 min · Phoenix Bypass Route
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9
Take the exit slight right toward Trekell Road
1480 ft · 43 sec
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10
Turn left onto South Trekell Road
3024 ft · 1 min · South Trekell Road
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11
Turn right onto West Hanna Street
1 mi · 2 min · West Hanna Street
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12
Turn left onto South Chuichu Road
5.4 mi · 8 min · South Chuichu Road
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13
Continue on Indian Route 15
33.2 mi · 46 min · Indian Route 15
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14
Turn left onto Indian Route 51
1.1 mi · 4 min · Indian Route 51
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15
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Mesa and San Luis.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Indian Route 15
Continue on Indian Route 15
33.2 mi · 00h 46m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Mostly Sunny leaving Mesa and Mostly Sunny near San Luis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mesa to San Luis?
The road trip is about 90.2 miles (145.2 km) and usually takes 02h 06m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Arizona City is a useful midpoint, sitting about 45.2 miles from Mesa and 45 miles from San Luis.
How much longer is the road route than the straight-line distance?
The direct path is about 75.4 miles (121.3 km), while the road route adds roughly 14.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM MST. If you want a more comfortable same-day return, try to leave by 2:18 PM MST.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $15.74 one way or $31.49 round trip. Estimated CO2 is about 28.3 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Mesa and Mostly Sunny near San Luis.
Stop Ideas Near Arizona City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
City of Casa Grande
Eloy City Hall
Arizona City Plaza
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Arizona City.
Maricopa
Phoenix (Airport), Arizona
Phoenix (Greyhound), Arizona
Tucson
Flight Path Map
This map shows the direct air route between Mesa and San Luis. Straight-line distance: 75.38 mi (121.32 km).
#1 Mesa
The fourth most populous city in Arizona and the center of the Mesa metropolitan area.
| Population | 528,159 |
| Coordinates | 33.4222700, -111.8226400 |
| Altitude | 378 |
| Country | United States |
#2 San Luis
Town in Yuma County, Arizona, United States
| Population | 36,242 |
| Coordinates | 32.3467300, -112.0409700 |
| Altitude | 547 |
| Country | United States |
End: San Luis (-112.04097, 32.34673)
Estimated Travel Time
Distance: 145 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 03h 00m |
| 40 mph (64.37 km/h) | 02h 15m |
| 50 mph (80.47 km/h) | 01h 48m |
| 60 mph (96.56 km/h) | 01h 30m |
| 70 mph (112.65 km/h) | 01h 17m |
| 80 mph (129 km/h) | 01h 07m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.95 | $15.74 | $31.49 |
| Mid-grade | $5.34 | $16.97 | $33.95 |
| Premium | $5.57 | $17.70 | $35.40 |
| Diesel | $6.37 | $20.24 | $40.49 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Arizona · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.