How far is Maysville, MO from St. Louis, MO?
The driving distance from Maysville, MO to St. Louis, MO is about 288.6 miles (464.5 km), with a travel time of about 04h 41m by car.
- The straight-line flight distance is about 239.2 miles (384.9 km).
- For a round trip, plan for roughly 09h 23m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 41m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Shelby County, Missouri
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Maysville and St. Louis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Maysville and St. Louis.
-
1
Start on West Main Street
712 ft · 16 sec · West Main Street
-
2
Turn right onto South Polk Street
8.9 mi · 16 min · South Polk Street
-
3
Turn left
162 mi · 3 hr 8 min
-
4
Take the exit slight right toward Veterans Road
1167 ft · 30 sec
-
5
Turn right onto Veterans Road
2.1 mi · 4 min · Veterans Road
-
6
At the end of the road, turn left onto County Road 422
85 m · 7 sec · County Road 422
-
7
Continue on Paris Gravel Road
2539 ft · 1 min · Paris Gravel Road
-
8
Take the ramp right
37 m · 3 sec
-
9
Merge slight left onto Avenue of the Saints
101.3 mi · 2 hr 1 min · Avenue of the Saints
-
10
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
-
11
Continue on Jack Buck Memorial Highway
5.8 mi · 7 min · Jack Buck Memorial Highway
-
12
Take the exit slight right toward 14th Street
1115 ft · 34 sec
-
13
Turn left onto South 14th Street
1715 ft · 42 sec · South 14th Street
-
14
Turn right onto Market Street
956 ft · 25 sec · Market Street
-
15
Arrive at your destination
0 m · 1 sec · Market Street
Car Route Details
A richer read on the saved driving route between Maysville and St. Louis.
Straightforward drive
The saved road route has a manageable number of maneuvers and should be easy to follow with normal attention to signs.
Longest stretch
Turn left
162 mi · 03h 08m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Showers And Thunderstorms leaving Maysville and Mostly Sunny near St. Louis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Maysville to St. Louis?
The road trip is about 288.6 miles (464.5 km) and usually takes 04h 41m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Hunnewell is a useful midpoint, sitting about 143.5 miles from Maysville and 145.2 miles from St. Louis.
How much longer is the road route than the straight-line distance?
The direct path is about 239.2 miles (384.9 km), while the road route adds roughly 49.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 7:36 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $38.39 one way or $76.78 round trip. Estimated CO2 is about 90.5 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Maysville and Mostly Sunny near St. Louis.
Stop Ideas Near Hunnewell
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Hunnewell.
Quincy
La Plata
Hermann
Fort Madison station
Flight Path Map
This map shows the direct air route between Maysville and St. Louis. Straight-line distance: 239.2 mi (384.95 km).
#1 Maysville
City in DeKalb County, Missouri, United States
| Population | 1,073 |
| Coordinates | 39.8891700, -94.3619000 |
| Altitude | 296 |
| Country | United States |
#2 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
End: Market Street (-90.197859, 38.627348)
Estimated Travel Time
Distance: 465 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 37m |
| 40 mph (64.37 km/h) | 07h 12m |
| 50 mph (80.47 km/h) | 05h 46m |
| 60 mph (96.56 km/h) | 04h 48m |
| 70 mph (112.65 km/h) | 04h 07m |
| 80 mph (129 km/h) | 03h 36m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $38.39 | $76.78 |
| Mid-grade | $4.25 | $43.30 | $86.59 |
| Premium | $4.65 | $47.38 | $94.76 |
| Diesel | $5.30 | $53.99 | $107.99 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.